Breakthrough Infections during Phase 1 and 2 Prime-Boost HIV-1 Vaccine Trials with Canarypox Vectors (ALVAC) and Booster Dose of Recombinant gp120 or gp160

Candidate human immunodeficiency virus (HIV)-1 vaccines that elicit cytotoxic T lymphocytes may modulate HIV infection, requiring a prototype evaluation to assess participants who become infected with HIV. Of 1497 participants in canarypox HIV-1 vaccine prime-boost trials, 28 (1.9%) acquired HIV-1 i...

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Veröffentlicht in:	The Journal of infectious diseases 2004-09, Vol.190 (5), p.903-907
Hauptverfasser:	Lee, Deborah, Graham, Barney S., Chiu, Ya-Lin, Gilbert, Peter B., McElrath, M. Juliana, Belshe, Robert B., Buchbinder, Susan P., Sheppard, Haynes W., Koblin, Beryl A., Mayer, Kenneth H., Keefer, Michael C., Mulligan, Mark J., Celum, Connie L.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS vaccines AIDS Vaccines - administration & dosage AIDS Vaccines - immunology Applied microbiology Avipoxvirus - genetics Biological and medical sciences Blood plasma Double-Blind Method Experimentation Female Fundamental and applied biological sciences. Psychology Genetic Vectors - administration & dosage Genetic Vectors - genetics Genetic Vectors - immunology HIV HIV 1 HIV Envelope Protein gp120 - administration & dosage HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - immunology HIV Envelope Protein gp160 - administration & dosage HIV Envelope Protein gp160 - genetics HIV Envelope Protein gp160 - immunology HIV Infections - physiopathology HIV Infections - prevention & control HIV-1 - pathogenicity HIV/AIDS Human immunodeficiency virus 1 Humans Immunization Immunization, Secondary Infections Infectious diseases Male Medical sciences Microbiology Miscellaneous Placebos Recombinant Proteins - administration & dosage Recombinant Proteins - genetics Recombinant Proteins - immunology RNA, Viral - blood T lymphocytes Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virology Viruses
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