Systematic identification of abundant A-to-I editing sites in the human transcriptome

RNA editing by members of the ADAR (adenosine deaminases acting on RNA) family leads to site-specific conversion of adenosine to inosine (A-to-I) in precursor messenger RNAs. Editing by ADARs is believed to occur in all metazoa, and is essential for mammalian development. Currently, only a limited n...

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Veröffentlicht in:	Nature biotechnology 2004-08, Vol.22 (8), p.1001-1005
Hauptverfasser:	Levanon, Erez Y, Eisenberg, Eli, Yelin, Rodrigo, Nemzer, Sergey, Hallegger, Martina, Shemesh, Ronen, Fligelman, Zipora Y, Shoshan, Avi, Pollock, Sarah R, Sztybel, Dan, Olshansky, Moshe, Rechavi, Gideon, Jantsch, Michael F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - genetics Base Pair Mismatch - genetics Base Pairing - genetics Base Sequence Biological and medical sciences Biotechnology Chromosome Mapping - methods Diverse techniques Expressed Sequence Tags Fundamental and applied biological sciences. Psychology Humans Inosine - genetics Mammals Molecular and cellular biology Molecular Sequence Data RNA Editing - genetics Sequence Alignment - methods Sequence Analysis, DNA - methods Sequence Analysis, RNA - methods Sequence Homology, Nucleic Acid Substrates Transcription Factors - genetics
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