A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes

Previous studies have suggested more than 20 genetic intervals that are associated with susceptibility to type 1 diabetes (T1D) 1 , 2 , but identification of specific genes has been challenging and largely limited to known candidate genes. Here, we report evidence for an association between T1D and...

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Veröffentlicht in:	Nature genetics 2004-08, Vol.36 (8), p.837-841
Hauptverfasser:	Guo, Dehuang, Li, Manyu, Zhang, Yan, Yang, Ping, Eckenrode, Sarah, Hopkins, Diane, Zheng, Weipeng, Purohit, Sharad, Podolsky, Robert H, Muir, Andrew, Wang, Jinzhao, Dong, Zheng, Brusko, Todd, Atkinson, Mark, Pozzilli, Paolo, Zeidler, Adina, Raffel, Leslie J, Jacob, Chaim O, Park, Yongsoo, Serrano-Rios, Manuel, Larrad, Maria T Martinez, Zhang, Zixin, Garchon, Henri-Jean, Bach, Jean-Francois, Rotter, Jerome I, She, Jin-Xiong, Wang, Cong-Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Amino Acid Sequence Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Causes of Diabetes Mellitus, Type 1 - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation Gene Function Genetic aspects Genetic Predisposition to Disease Genetic regulation Genetics of eukaryotes. Biological and molecular evolution Health aspects Human Genetics Humans letter Molecular Sequence Data Physical Chromosome Mapping Physiological aspects Polymorphism, Single Nucleotide Sequence Homology, Amino Acid Single nucleotide polymorphisms Small Ubiquitin-Related Modifier Proteins - genetics Small Ubiquitin-Related Modifier Proteins - physiology Type 1 diabetes
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