Impact of Fibronectin Fragments on the Transendothelial Migration of HIV-Infected Leukocytes and the Development of Subendothelial Foci of Infectious Leukocytes

Leukocyte infiltrates that can serve as viral reservoirs, and sites for viral replication are found in many organs of HIV-1-infected patients. Patients whose blood leukocytes migrate across confluent endothelial monolayers ex vivo and transmit infectious virus to mononuclear leukocytes (MNLs) lodged...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-08, Vol.173 (4), p.2746-2754
Hauptverfasser:	Birdsall, Holly H, Porter, Wendy J, Green, David M, Rubio, Jose, Trial, JoAnn, Rossen, Roger D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion Chemotaxis, Leukocyte - drug effects Dendritic Cells - drug effects Dendritic Cells - immunology Dose-Response Relationship, Drug Endothelium, Vascular - immunology Fibronectins - pharmacology Flow Cytometry HIV Infections - immunology HIV-1 - pathogenicity HLA-DR Antigens - immunology Human immunodeficiency virus 1 Humans Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - virology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Peptides - pharmacology Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - drug effects
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