Decrease of Interleukin-10-Producing T Cells in the Peripheral Blood of Severe Unstable Atopic Asthmatics
Background: Although IL-10 is known as an immunoregulatory cytokine produced by various cells including T cells, its basic profile in atopic asthma remains uncertain. Objective: The profiles of IL-10 production in circulating CD4+ T cells of atopic asthmatics were investigated with respect to clinic...
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| Veröffentlicht in: | International archives of allergy and immunology 2004-08, Vol.134 (4), p.295-302 |
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| creator | Matsumoto, Koichiro Inoue, Hiromasa Fukuyama, Satoru Tsuda, Miyuki Ikegami, Tomomi Kibe, Atsuko Yoshiura, Yuki Komori, Masashi Hamasaki, Naotaka Aizawa, Hisamichi Nakanishi, Yoichi |
| description | Background: Although IL-10 is known as an immunoregulatory cytokine produced by various cells including T cells, its basic profile in atopic asthma remains uncertain. Objective: The profiles of IL-10 production in circulating CD4+ T cells of atopic asthmatics were investigated with respect to clinical severity. Methods: Forty atopic asthmatics were divided into three groups: mild, and severe but stable and severe unstable asthmatics. Eosinophils were counted in the peripheral blood and sputum, and exhaled nitric oxide was assessed. PBMCs were stimulated with or without anti-CD3 and anti-CD28 antibodies and then processed for detecting IL-10-producing CD4+ cells using flow cytometry. Results: There was no difference in the eosinophil count in blood or sputum and in nitric oxide level among the three groups. IL-10-producing CD4+ cells were mainly detected in a CD45RO+ memory population. The frequency of IL-10-producing cells after stimulation was significantly lower in the severe unstable group compared to the mild group. In addition, the frequency of IL-10-producing cells in the severe unstable group was significantly lower than that in the severe stable group despite the fact that both groups received similar treatments with high-dose inhaled corticosteroids. The IL-10 production of CD4+CD45RO+ cells in response to dexamethasone did not differ among the three groups. Conclusions: IL-10-producing CD4+CD45RO+ cells in the peripheral blood are decreased in severe unstable asthmatics, which is not explained by the effect of high-dose inhaled corticosteroid medication. |
| doi_str_mv | 10.1159/000079167 |
| format | Article |
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Objective: The profiles of IL-10 production in circulating CD4+ T cells of atopic asthmatics were investigated with respect to clinical severity. Methods: Forty atopic asthmatics were divided into three groups: mild, and severe but stable and severe unstable asthmatics. Eosinophils were counted in the peripheral blood and sputum, and exhaled nitric oxide was assessed. PBMCs were stimulated with or without anti-CD3 and anti-CD28 antibodies and then processed for detecting IL-10-producing CD4+ cells using flow cytometry. Results: There was no difference in the eosinophil count in blood or sputum and in nitric oxide level among the three groups. IL-10-producing CD4+ cells were mainly detected in a CD45RO+ memory population. The frequency of IL-10-producing cells after stimulation was significantly lower in the severe unstable group compared to the mild group. In addition, the frequency of IL-10-producing cells in the severe unstable group was significantly lower than that in the severe stable group despite the fact that both groups received similar treatments with high-dose inhaled corticosteroids. The IL-10 production of CD4+CD45RO+ cells in response to dexamethasone did not differ among the three groups. Conclusions: IL-10-producing CD4+CD45RO+ cells in the peripheral blood are decreased in severe unstable asthmatics, which is not explained by the effect of high-dose inhaled corticosteroid medication.</description><identifier>ISSN: 1018-2438</identifier><identifier>EISSN: 1423-0097</identifier><identifier>DOI: 10.1159/000079167</identifier><identifier>PMID: 15205561</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Asthma ; Asthma - metabolism ; Asthma - physiopathology ; Biological and medical sciences ; Biomarkers - blood ; Blood ; Bronchial Provocation Tests ; CD4-Positive T-Lymphocytes - drug effects ; CD4-Positive T-Lymphocytes - metabolism ; Cytokines ; Dexamethasone - administration & dosage ; Female ; Flow Cytometry ; Forced Expiratory Volume - drug effects ; Forced Expiratory Volume - physiology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Glucocorticoids - administration & dosage ; Humans ; Hypersensitivity, Immediate - metabolism ; Hypersensitivity, Immediate - physiopathology ; Immunology ; Immunopathology ; Interleukin-10 - metabolism ; Leukocyte Common Antigens - drug effects ; Leukocyte Common Antigens - metabolism ; Leukocytes, Mononuclear - drug effects ; Leukocytes, Mononuclear - metabolism ; Male ; Medical sciences ; Middle Aged ; Original Paper ; Respiratory system ; Severity of Illness Index ; Sputum - chemistry ; Sputum - metabolism ; T cell receptors ; T-Lymphocyte Subsets - drug effects ; T-Lymphocyte Subsets - metabolism</subject><ispartof>International archives of allergy and immunology, 2004-08, Vol.134 (4), p.295-302</ispartof><rights>2004 S. Karger AG, Basel</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 S. Karger AG, Basel</rights><rights>Copyright (c) 2004 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-a33d6b3667603d5d2a0f2c76f98be22229c8855d1533ad200beb74836198fbe83</citedby><cites>FETCH-LOGICAL-c416t-a33d6b3667603d5d2a0f2c76f98be22229c8855d1533ad200beb74836198fbe83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15988084$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15205561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsumoto, Koichiro</creatorcontrib><creatorcontrib>Inoue, Hiromasa</creatorcontrib><creatorcontrib>Fukuyama, Satoru</creatorcontrib><creatorcontrib>Tsuda, Miyuki</creatorcontrib><creatorcontrib>Ikegami, Tomomi</creatorcontrib><creatorcontrib>Kibe, Atsuko</creatorcontrib><creatorcontrib>Yoshiura, Yuki</creatorcontrib><creatorcontrib>Komori, Masashi</creatorcontrib><creatorcontrib>Hamasaki, Naotaka</creatorcontrib><creatorcontrib>Aizawa, Hisamichi</creatorcontrib><creatorcontrib>Nakanishi, Yoichi</creatorcontrib><title>Decrease of Interleukin-10-Producing T Cells in the Peripheral Blood of Severe Unstable Atopic Asthmatics</title><title>International archives of allergy and immunology</title><addtitle>Int Arch Allergy Immunol</addtitle><description>Background: Although IL-10 is known as an immunoregulatory cytokine produced by various cells including T cells, its basic profile in atopic asthma remains uncertain. Objective: The profiles of IL-10 production in circulating CD4+ T cells of atopic asthmatics were investigated with respect to clinical severity. Methods: Forty atopic asthmatics were divided into three groups: mild, and severe but stable and severe unstable asthmatics. Eosinophils were counted in the peripheral blood and sputum, and exhaled nitric oxide was assessed. PBMCs were stimulated with or without anti-CD3 and anti-CD28 antibodies and then processed for detecting IL-10-producing CD4+ cells using flow cytometry. Results: There was no difference in the eosinophil count in blood or sputum and in nitric oxide level among the three groups. IL-10-producing CD4+ cells were mainly detected in a CD45RO+ memory population. The frequency of IL-10-producing cells after stimulation was significantly lower in the severe unstable group compared to the mild group. In addition, the frequency of IL-10-producing cells in the severe unstable group was significantly lower than that in the severe stable group despite the fact that both groups received similar treatments with high-dose inhaled corticosteroids. The IL-10 production of CD4+CD45RO+ cells in response to dexamethasone did not differ among the three groups. Conclusions: IL-10-producing CD4+CD45RO+ cells in the peripheral blood are decreased in severe unstable asthmatics, which is not explained by the effect of high-dose inhaled corticosteroid medication.</description><subject>Adult</subject><subject>Asthma</subject><subject>Asthma - metabolism</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood</subject><subject>Bronchial Provocation Tests</subject><subject>CD4-Positive T-Lymphocytes - drug effects</subject><subject>CD4-Positive T-Lymphocytes - metabolism</subject><subject>Cytokines</subject><subject>Dexamethasone - administration & dosage</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Forced Expiratory Volume - drug effects</subject><subject>Forced Expiratory Volume - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - metabolism</subject><subject>Hypersensitivity, Immediate - physiopathology</subject><subject>Immunology</subject><subject>Immunopathology</subject><subject>Interleukin-10 - metabolism</subject><subject>Leukocyte Common Antigens - drug effects</subject><subject>Leukocyte Common Antigens - metabolism</subject><subject>Leukocytes, Mononuclear - drug effects</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Respiratory system</subject><subject>Severity of Illness Index</subject><subject>Sputum - chemistry</subject><subject>Sputum - metabolism</subject><subject>T cell receptors</subject><subject>T-Lymphocyte Subsets - drug effects</subject><subject>T-Lymphocyte Subsets - metabolism</subject><issn>1018-2438</issn><issn>1423-0097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0c9rFDEUB_AgFlurB8-CBEGhh9H8mPw6jqutCwULtuchk7zppp2dTJMZwf_e1F1aEcF3SQ6fvHwfD6FXlHygVJiPpJQyVKon6IjWjFeEGPW03AnVFau5PkTPc74hpGAtn6FDKhgRQtIjFD6DS2Az4Njj9ThDGmC5DWNFSXWRol9cGK_xJV7BMGQcRjxvAF9ACtMGkh3wpyFGf__2O_yABPhqzLPtBsDNHKfgcJPnzdbOweUX6KC3Q4aX-_MYXZ1-uVx9rc6_na1XzXnlairnynLuZcelVJJwLzyzpGdOyd7oDlgp47QWwlPBufWMkA46VWsuqdF9B5ofo_e7vlOKdwvkud2G7Ep8O0Jccls6C02F-i-kSgsjJSvw7V_wJi5pLEO0jFFNVG1kQSc75FLMOUHfTilsbfrZUtLeb6l92FKxb_YNl24L_lHu11LAuz2w2dmhT3Z0If_hjNZE14_Jbm26hvQA1k3z-6d28n1Br_-Jdll-AZhrq3Q</recordid><startdate>200408</startdate><enddate>200408</enddate><creator>Matsumoto, Koichiro</creator><creator>Inoue, Hiromasa</creator><creator>Fukuyama, Satoru</creator><creator>Tsuda, Miyuki</creator><creator>Ikegami, Tomomi</creator><creator>Kibe, Atsuko</creator><creator>Yoshiura, Yuki</creator><creator>Komori, Masashi</creator><creator>Hamasaki, Naotaka</creator><creator>Aizawa, Hisamichi</creator><creator>Nakanishi, Yoichi</creator><general>Karger</general><general>S. Karger AG</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>200408</creationdate><title>Decrease of Interleukin-10-Producing T Cells in the Peripheral Blood of Severe Unstable Atopic Asthmatics</title><author>Matsumoto, Koichiro ; Inoue, Hiromasa ; Fukuyama, Satoru ; Tsuda, Miyuki ; Ikegami, Tomomi ; Kibe, Atsuko ; Yoshiura, Yuki ; Komori, Masashi ; Hamasaki, Naotaka ; Aizawa, Hisamichi ; Nakanishi, Yoichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-a33d6b3667603d5d2a0f2c76f98be22229c8855d1533ad200beb74836198fbe83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Asthma</topic><topic>Asthma - metabolism</topic><topic>Asthma - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood</topic><topic>Bronchial Provocation Tests</topic><topic>CD4-Positive T-Lymphocytes - drug effects</topic><topic>CD4-Positive T-Lymphocytes - metabolism</topic><topic>Cytokines</topic><topic>Dexamethasone - administration & dosage</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Forced Expiratory Volume - drug effects</topic><topic>Forced Expiratory Volume - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - metabolism</topic><topic>Hypersensitivity, Immediate - physiopathology</topic><topic>Immunology</topic><topic>Immunopathology</topic><topic>Interleukin-10 - metabolism</topic><topic>Leukocyte Common Antigens - drug effects</topic><topic>Leukocyte Common Antigens - metabolism</topic><topic>Leukocytes, Mononuclear - drug effects</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Respiratory system</topic><topic>Severity of Illness Index</topic><topic>Sputum - chemistry</topic><topic>Sputum - metabolism</topic><topic>T cell receptors</topic><topic>T-Lymphocyte Subsets - drug effects</topic><topic>T-Lymphocyte Subsets - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsumoto, Koichiro</creatorcontrib><creatorcontrib>Inoue, Hiromasa</creatorcontrib><creatorcontrib>Fukuyama, Satoru</creatorcontrib><creatorcontrib>Tsuda, Miyuki</creatorcontrib><creatorcontrib>Ikegami, Tomomi</creatorcontrib><creatorcontrib>Kibe, Atsuko</creatorcontrib><creatorcontrib>Yoshiura, Yuki</creatorcontrib><creatorcontrib>Komori, Masashi</creatorcontrib><creatorcontrib>Hamasaki, Naotaka</creatorcontrib><creatorcontrib>Aizawa, Hisamichi</creatorcontrib><creatorcontrib>Nakanishi, Yoichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International archives of allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsumoto, Koichiro</au><au>Inoue, Hiromasa</au><au>Fukuyama, Satoru</au><au>Tsuda, Miyuki</au><au>Ikegami, Tomomi</au><au>Kibe, Atsuko</au><au>Yoshiura, Yuki</au><au>Komori, Masashi</au><au>Hamasaki, Naotaka</au><au>Aizawa, Hisamichi</au><au>Nakanishi, Yoichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decrease of Interleukin-10-Producing T Cells in the Peripheral Blood of Severe Unstable Atopic Asthmatics</atitle><jtitle>International archives of allergy and immunology</jtitle><addtitle>Int Arch Allergy Immunol</addtitle><date>2004-08</date><risdate>2004</risdate><volume>134</volume><issue>4</issue><spage>295</spage><epage>302</epage><pages>295-302</pages><issn>1018-2438</issn><eissn>1423-0097</eissn><abstract>Background: Although IL-10 is known as an immunoregulatory cytokine produced by various cells including T cells, its basic profile in atopic asthma remains uncertain. Objective: The profiles of IL-10 production in circulating CD4+ T cells of atopic asthmatics were investigated with respect to clinical severity. Methods: Forty atopic asthmatics were divided into three groups: mild, and severe but stable and severe unstable asthmatics. Eosinophils were counted in the peripheral blood and sputum, and exhaled nitric oxide was assessed. PBMCs were stimulated with or without anti-CD3 and anti-CD28 antibodies and then processed for detecting IL-10-producing CD4+ cells using flow cytometry. Results: There was no difference in the eosinophil count in blood or sputum and in nitric oxide level among the three groups. IL-10-producing CD4+ cells were mainly detected in a CD45RO+ memory population. The frequency of IL-10-producing cells after stimulation was significantly lower in the severe unstable group compared to the mild group. In addition, the frequency of IL-10-producing cells in the severe unstable group was significantly lower than that in the severe stable group despite the fact that both groups received similar treatments with high-dose inhaled corticosteroids. The IL-10 production of CD4+CD45RO+ cells in response to dexamethasone did not differ among the three groups. Conclusions: IL-10-producing CD4+CD45RO+ cells in the peripheral blood are decreased in severe unstable asthmatics, which is not explained by the effect of high-dose inhaled corticosteroid medication.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>15205561</pmid><doi>10.1159/000079167</doi><tpages>8</tpages></addata></record> |
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| ispartof | International archives of allergy and immunology, 2004-08, Vol.134 (4), p.295-302 |
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| subjects | Adult Asthma Asthma - metabolism Asthma - physiopathology Biological and medical sciences Biomarkers - blood Blood Bronchial Provocation Tests CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism Cytokines Dexamethasone - administration & dosage Female Flow Cytometry Forced Expiratory Volume - drug effects Forced Expiratory Volume - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology Glucocorticoids - administration & dosage Humans Hypersensitivity, Immediate - metabolism Hypersensitivity, Immediate - physiopathology Immunology Immunopathology Interleukin-10 - metabolism Leukocyte Common Antigens - drug effects Leukocyte Common Antigens - metabolism Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Male Medical sciences Middle Aged Original Paper Respiratory system Severity of Illness Index Sputum - chemistry Sputum - metabolism T cell receptors T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - metabolism |
| title | Decrease of Interleukin-10-Producing T Cells in the Peripheral Blood of Severe Unstable Atopic Asthmatics |
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