Rate of Production of Plasma and Very-Low-Density Lipoprotein (VLDL) Apolipoprotein C-III Is Strongly Related to the Concentration and Level of Production of VLDL Triglyceride in Male Subjects with Different Body Weights and Levels of Insulin Sensitivity
Overweight individuals with reduced insulin sensitivity often have mild to moderate hypertriglyceridemia. To investigate the role of apolipoprotein (apo)C-III metabolism in the etiology of hypertriglyceridemia in these individuals, we investigated 10 male subjects with different body weights (body m...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2004-08, Vol.89 (8), p.3949-3955 |
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| creator | Cohn, Jeffrey S. Patterson, Bruce W. Uffelman, Kris D. Davignon, Jean Steiner, George |
| description | Overweight individuals with reduced insulin sensitivity often have mild to moderate hypertriglyceridemia. To investigate the role of apolipoprotein (apo)C-III metabolism in the etiology of hypertriglyceridemia in these individuals, we investigated 10 male subjects with different body weights (body mass index, 24–34 kg/m2) and insulin sensitivity (homeostasis model assessment, 4.7–35.0). Total plasma and very-low-density lipoprotein (VLDL) apoC-III kinetics, as well as VLDL triglyceride (TG) and VLDL apoB kinetics, were measured with iv injected stable isotopes. The apoC-III, TG, and apoB levels in VLDL ranged from 2.9–18.2 mg/dl, 0.49–2.89 mmol/liter, and 6.7–29.3 mg/dl, respectively. Mean production rates (PRs) were: VLDL apoC-III, 20.2 ± 4.1 μmol/d (range, 8.0–44.8); VLDL TG, 26.9 ± 4.6 mmol/d (range, 10.2–51.1); and VLDL apoB, 4.4 ± 0.8 μmol/d (range, 1.5–9.1). VLDL apoC-III PRs were significantly correlated with body mass index, homeostasis model assessment, and plasma TG (r = 0.66, P < 0.05; r = 0.80, P < 0.01; r = 0.95, P < 0.001, respectively). Similar correlations were found for plasma apoC-III PRs (r = 0.70, P < 0.05; r = 0.67, P < 0.05; r = 0.80, P < 0.01, respectively). Fractional catabolic rates (FCRs) were not significantly related to metabolic variables. VLDL TG levels were strongly related to VLDL apoC-III levels (r = 0.99, P < 0.001) and VLDL apoC-III PRs (r = 0.94, P < 0.001). VLDL apoC-III levels were more strongly correlated with VLDL TG PRs (r = 0.81, P < 0.01) than with VLDL TG FCRs or VLDL apoB FCRs (r = −0.53, P = 0.12; r = −0.37, P = 0.29). These results suggest that increased hepatic production of VLDL apoC-III is characteristic of subjects with higher body weights and lower levels of insulin sensitivity and is strongly related to the plasma concentration and level of production of VLDL TG. |
| doi_str_mv | 10.1210/jc.2003-032056 |
| format | Article |
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To investigate the role of apolipoprotein (apo)C-III metabolism in the etiology of hypertriglyceridemia in these individuals, we investigated 10 male subjects with different body weights (body mass index, 24–34 kg/m2) and insulin sensitivity (homeostasis model assessment, 4.7–35.0). Total plasma and very-low-density lipoprotein (VLDL) apoC-III kinetics, as well as VLDL triglyceride (TG) and VLDL apoB kinetics, were measured with iv injected stable isotopes. The apoC-III, TG, and apoB levels in VLDL ranged from 2.9–18.2 mg/dl, 0.49–2.89 mmol/liter, and 6.7–29.3 mg/dl, respectively. Mean production rates (PRs) were: VLDL apoC-III, 20.2 ± 4.1 μmol/d (range, 8.0–44.8); VLDL TG, 26.9 ± 4.6 mmol/d (range, 10.2–51.1); and VLDL apoB, 4.4 ± 0.8 μmol/d (range, 1.5–9.1). VLDL apoC-III PRs were significantly correlated with body mass index, homeostasis model assessment, and plasma TG (r = 0.66, P < 0.05; r = 0.80, P < 0.01; r = 0.95, P < 0.001, respectively). Similar correlations were found for plasma apoC-III PRs (r = 0.70, P < 0.05; r = 0.67, P < 0.05; r = 0.80, P < 0.01, respectively). Fractional catabolic rates (FCRs) were not significantly related to metabolic variables. VLDL TG levels were strongly related to VLDL apoC-III levels (r = 0.99, P < 0.001) and VLDL apoC-III PRs (r = 0.94, P < 0.001). VLDL apoC-III levels were more strongly correlated with VLDL TG PRs (r = 0.81, P < 0.01) than with VLDL TG FCRs or VLDL apoB FCRs (r = −0.53, P = 0.12; r = −0.37, P = 0.29). These results suggest that increased hepatic production of VLDL apoC-III is characteristic of subjects with higher body weights and lower levels of insulin sensitivity and is strongly related to the plasma concentration and level of production of VLDL TG.]]></description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2003-032056</identifier><identifier>PMID: 15292332</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adult ; Apolipoprotein C-III ; Apolipoproteins C - biosynthesis ; Biological and medical sciences ; Body Weight ; Endocrinopathies ; Fundamental and applied biological sciences. Psychology ; Humans ; Insulin - physiology ; Insulin Resistance - physiology ; Kinetics ; Lipoproteins, VLDL - blood ; Male ; Medical sciences ; Middle Aged ; Osmolar Concentration ; Triglycerides - blood ; Vertebrates: endocrinology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2004-08, Vol.89 (8), p.3949-3955</ispartof><rights>Copyright © Oxford University Press 2015</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4525-81f935f7473e15dd5820abd987331b55b238253787b0dae39a0aa4d142b149633</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16006745$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15292332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohn, Jeffrey S.</creatorcontrib><creatorcontrib>Patterson, Bruce W.</creatorcontrib><creatorcontrib>Uffelman, Kris D.</creatorcontrib><creatorcontrib>Davignon, Jean</creatorcontrib><creatorcontrib>Steiner, George</creatorcontrib><title>Rate of Production of Plasma and Very-Low-Density Lipoprotein (VLDL) Apolipoprotein C-III Is Strongly Related to the Concentration and Level of Production of VLDL Triglyceride in Male Subjects with Different Body Weights and Levels of Insulin Sensitivity</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description><![CDATA[Overweight individuals with reduced insulin sensitivity often have mild to moderate hypertriglyceridemia. To investigate the role of apolipoprotein (apo)C-III metabolism in the etiology of hypertriglyceridemia in these individuals, we investigated 10 male subjects with different body weights (body mass index, 24–34 kg/m2) and insulin sensitivity (homeostasis model assessment, 4.7–35.0). Total plasma and very-low-density lipoprotein (VLDL) apoC-III kinetics, as well as VLDL triglyceride (TG) and VLDL apoB kinetics, were measured with iv injected stable isotopes. The apoC-III, TG, and apoB levels in VLDL ranged from 2.9–18.2 mg/dl, 0.49–2.89 mmol/liter, and 6.7–29.3 mg/dl, respectively. Mean production rates (PRs) were: VLDL apoC-III, 20.2 ± 4.1 μmol/d (range, 8.0–44.8); VLDL TG, 26.9 ± 4.6 mmol/d (range, 10.2–51.1); and VLDL apoB, 4.4 ± 0.8 μmol/d (range, 1.5–9.1). VLDL apoC-III PRs were significantly correlated with body mass index, homeostasis model assessment, and plasma TG (r = 0.66, P < 0.05; r = 0.80, P < 0.01; r = 0.95, P < 0.001, respectively). Similar correlations were found for plasma apoC-III PRs (r = 0.70, P < 0.05; r = 0.67, P < 0.05; r = 0.80, P < 0.01, respectively). Fractional catabolic rates (FCRs) were not significantly related to metabolic variables. VLDL TG levels were strongly related to VLDL apoC-III levels (r = 0.99, P < 0.001) and VLDL apoC-III PRs (r = 0.94, P < 0.001). VLDL apoC-III levels were more strongly correlated with VLDL TG PRs (r = 0.81, P < 0.01) than with VLDL TG FCRs or VLDL apoB FCRs (r = −0.53, P = 0.12; r = −0.37, P = 0.29). These results suggest that increased hepatic production of VLDL apoC-III is characteristic of subjects with higher body weights and lower levels of insulin sensitivity and is strongly related to the plasma concentration and level of production of VLDL TG.]]></description><subject>Adult</subject><subject>Apolipoprotein C-III</subject><subject>Apolipoproteins C - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Endocrinopathies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Insulin - physiology</subject><subject>Insulin Resistance - physiology</subject><subject>Kinetics</subject><subject>Lipoproteins, VLDL - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Osmolar Concentration</subject><subject>Triglycerides - blood</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UkmP0zAUjhCIGQpXjsgXEBxSvMRZjjMtS6Qg0HQYuEVO_DJ1ce1iO1P1zyPcRQwSwpJlPftb3uIkeU7wlFCC3676KcWYpZhRzPMHyTmpMp4WpCoeJucYU5JWBf1-ljzxfoUxyTLOHidnhNOKMkbPk19XIgCyA_rirBz7oKw5RFr4tUDCSHQDbpc2dpvOwXgVdqhRG7txNoAy6PVNM2_eoIuN1X_dztK6rlHt0SI4a271Dl2Bjj4SBYvCEtDMmh5McOLgt3dp4A70v3ns5dG1U1GjB6ckoCj_SWhAi7FbQR882qqwRHM1DOCiJLq0coe-gbpdxrc_yn4vVhs_6shfHApRd7GYp8mjQWgPz07nJPn6_t317GPafP5Qzy6atM845WlJhorxocgKBoRLyUuKRSersmCMdJx3lJWUs6IsOiwFsEpgITJJMtqRrMoZmySvjrqxRT9H8KFdK9-D1sKAHX2b5wXPaVlG4PQI7J313sHQbpxaC7drCW73E29XfbufeHuceCS8OCmP3RrkPfw04gh4eQII3ws9OGF65e9xOcZ5Eb_FJMmOuK3VAZz_occtuHYJQodli-PK8qJMo3eGyxilcfM9jR9pYKTtnTKwceB9u7KjM7Gl_8v7N9Ao11o</recordid><startdate>200408</startdate><enddate>200408</enddate><creator>Cohn, Jeffrey S.</creator><creator>Patterson, Bruce W.</creator><creator>Uffelman, Kris D.</creator><creator>Davignon, Jean</creator><creator>Steiner, George</creator><general>Endocrine Society</general><general>Copyright Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200408</creationdate><title>Rate of Production of Plasma and Very-Low-Density Lipoprotein (VLDL) Apolipoprotein C-III Is Strongly Related to the Concentration and Level of Production of VLDL Triglyceride in Male Subjects with Different Body Weights and Levels of Insulin Sensitivity</title><author>Cohn, Jeffrey S. ; Patterson, Bruce W. ; Uffelman, Kris D. ; Davignon, Jean ; Steiner, George</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4525-81f935f7473e15dd5820abd987331b55b238253787b0dae39a0aa4d142b149633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Apolipoprotein C-III</topic><topic>Apolipoproteins C - biosynthesis</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Endocrinopathies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Insulin - physiology</topic><topic>Insulin Resistance - physiology</topic><topic>Kinetics</topic><topic>Lipoproteins, VLDL - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Osmolar Concentration</topic><topic>Triglycerides - blood</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohn, Jeffrey S.</creatorcontrib><creatorcontrib>Patterson, Bruce W.</creatorcontrib><creatorcontrib>Uffelman, Kris D.</creatorcontrib><creatorcontrib>Davignon, Jean</creatorcontrib><creatorcontrib>Steiner, George</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohn, Jeffrey S.</au><au>Patterson, Bruce W.</au><au>Uffelman, Kris D.</au><au>Davignon, Jean</au><au>Steiner, George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rate of Production of Plasma and Very-Low-Density Lipoprotein (VLDL) Apolipoprotein C-III Is Strongly Related to the Concentration and Level of Production of VLDL Triglyceride in Male Subjects with Different Body Weights and Levels of Insulin Sensitivity</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2004-08</date><risdate>2004</risdate><volume>89</volume><issue>8</issue><spage>3949</spage><epage>3955</epage><pages>3949-3955</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract><![CDATA[Overweight individuals with reduced insulin sensitivity often have mild to moderate hypertriglyceridemia. To investigate the role of apolipoprotein (apo)C-III metabolism in the etiology of hypertriglyceridemia in these individuals, we investigated 10 male subjects with different body weights (body mass index, 24–34 kg/m2) and insulin sensitivity (homeostasis model assessment, 4.7–35.0). Total plasma and very-low-density lipoprotein (VLDL) apoC-III kinetics, as well as VLDL triglyceride (TG) and VLDL apoB kinetics, were measured with iv injected stable isotopes. The apoC-III, TG, and apoB levels in VLDL ranged from 2.9–18.2 mg/dl, 0.49–2.89 mmol/liter, and 6.7–29.3 mg/dl, respectively. Mean production rates (PRs) were: VLDL apoC-III, 20.2 ± 4.1 μmol/d (range, 8.0–44.8); VLDL TG, 26.9 ± 4.6 mmol/d (range, 10.2–51.1); and VLDL apoB, 4.4 ± 0.8 μmol/d (range, 1.5–9.1). VLDL apoC-III PRs were significantly correlated with body mass index, homeostasis model assessment, and plasma TG (r = 0.66, P < 0.05; r = 0.80, P < 0.01; r = 0.95, P < 0.001, respectively). Similar correlations were found for plasma apoC-III PRs (r = 0.70, P < 0.05; r = 0.67, P < 0.05; r = 0.80, P < 0.01, respectively). Fractional catabolic rates (FCRs) were not significantly related to metabolic variables. VLDL TG levels were strongly related to VLDL apoC-III levels (r = 0.99, P < 0.001) and VLDL apoC-III PRs (r = 0.94, P < 0.001). VLDL apoC-III levels were more strongly correlated with VLDL TG PRs (r = 0.81, P < 0.01) than with VLDL TG FCRs or VLDL apoB FCRs (r = −0.53, P = 0.12; r = −0.37, P = 0.29). These results suggest that increased hepatic production of VLDL apoC-III is characteristic of subjects with higher body weights and lower levels of insulin sensitivity and is strongly related to the plasma concentration and level of production of VLDL TG.]]></abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>15292332</pmid><doi>10.1210/jc.2003-032056</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Apolipoprotein C-III Apolipoproteins C - biosynthesis Biological and medical sciences Body Weight Endocrinopathies Fundamental and applied biological sciences. Psychology Humans Insulin - physiology Insulin Resistance - physiology Kinetics Lipoproteins, VLDL - blood Male Medical sciences Middle Aged Osmolar Concentration Triglycerides - blood Vertebrates: endocrinology |
| title | Rate of Production of Plasma and Very-Low-Density Lipoprotein (VLDL) Apolipoprotein C-III Is Strongly Related to the Concentration and Level of Production of VLDL Triglyceride in Male Subjects with Different Body Weights and Levels of Insulin Sensitivity |
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