Detection of Quadruplex DNA Structures in Human Telomeres by a Fluorescent Carbazole Derivative

Single-stranded telomeric DNA tends to form a four-base-paired planar structure termed G-quadruplex. This structure was easily formed in vitro in the presence of monovalent cations. However, the existence of this structure in native human telomeres is unclear. Here we address this important question...

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Veröffentlicht in:	Analytical chemistry (Washington) 2004-08, Vol.76 (15), p.4490-4494
Hauptverfasser:	Chang, Cheng-Chung, Kuo, I.-Chun, Ling, I.-Fang, Chen, Chin-Tin, Chen, Huei-Chin, Lou, Pei-Jen, Lin, Jing-Jer, Chang, Ta-Chau
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical biochemistry: general aspects, technics, instrumentation Analytical chemistry Analytical, structural and metabolic biochemistry Binding Sites Biological and medical sciences Carbazoles - chemistry Cell Line Cell Nucleus - ultrastructure Chemistry Chromosomes Deoxyribonucleic acid DNA DNA - chemistry Exact sciences and technology Fluorescence Fluorescent Dyes Fundamental and applied biological sciences. Psychology Humans Metaphase Microscopy, Confocal Pyridinium Compounds - chemistry Spectrometric and optical methods Spectrometry, Fluorescence Telomere - genetics Telomere - ultrastructure
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