Antibody ligation of murine Ly-6G induces neutropenia, blood flow cessation, and death via complement-dependent and independent mechanisms

Ly‐6G is a member of the Ly‐6 family of GPI‐linked proteins, which is expressed on murine neutrophils. Antibodies against Ly‐6G cause neutropenia, and fatal reactions also develop if mice are primed with TNF‐α prior to antibody treatment. We have investigated the mechanisms behind these responses to...

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Veröffentlicht in:	Journal of leukocyte biology 2009-01, Vol.85 (1), p.55-63
Hauptverfasser:	Abbitt, Katherine B., Cotter, Matthew J., Ridger, Victoria C., Crossman, David C., Hellewell, Paul G., Norman, Keith E.
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion Animals Antibodies, Monoclonal - pharmacology Antigens, Ly - immunology CD11b Antigen - immunology CD18 Antigens - immunology cell activation Complement System Proteins - immunology Cross-Linking Reagents Mice Mice, Inbred C57BL Mice, Knockout Microcirculation - immunology Neutropenia - immunology Neutropenia - mortality Neutropenia - physiopathology neutrophils Neutrophils - immunology Receptors, IgG - genetics Receptors, IgG - immunology Respiration Respiratory Insufficiency - immunology Respiratory Insufficiency - mortality Respiratory Insufficiency - physiopathology Tumor Necrosis Factor-alpha - immunology
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