Topical estrogen protects against SIV vaginal transmission without evidence of systemic effect
Accumulating data suggest that the state of the vaginal epithelium affects a woman's risk of HIV vaginal transmission and several human and non-human primate studies have shown that the rate of HIV or SIV vaginal transmission is decreased when estrogen is dominant. Systemic estrogen can protect...
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| Veröffentlicht in: | AIDS (London) 2004-08, Vol.18 (12), p.1637-1643 |
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| creator | SMITH, Stephen M MEFFORD, Megan SODORA, Donald KLASE, Zachary SINGH, Mahender ALEXANDER, Nancy HESS, David MARX, Preston A |
| description | Accumulating data suggest that the state of the vaginal epithelium affects a woman's risk of HIV vaginal transmission and several human and non-human primate studies have shown that the rate of HIV or SIV vaginal transmission is decreased when estrogen is dominant. Systemic estrogen can protect against SIV vaginal transmission.
To determine the safety and efficacy of topical estrogen in preventing SIV vaginal transmission.
The non-human primate model of HIV vaginal transmission was used to assess vaginal estriol cream in ovariectomized macaques.
Twelve macaques were treated intravaginally with estriol and eight with placebo cream twice a week. The vaginal and systemic effects of estriol were determined by colposcopy and serum luteinizing hormone, levels of which would decline in the presence of systemic estrogen. After 5 weeks of therapy, the animals were challenged vaginally with pathogenic SIVmac251.
Vaginal estriol resulted in minimal serum estriol levels and had no effect on serum luteinizing hormone levels. Vaginal epithelia cornified and thickened significantly in response to estriol therapy. One of the estriol-treated animals became infected after this single challenge, while six of the control animals became infected (P = 0.0044).
These data demonstrate that topical vaginal estriol can strongly protect against SIV vaginal transmission, while having no detectable systemic effect. These results support the study of topical vaginal estriol in preventing HIV vaginal transmission in at-risk women. |
| doi_str_mv | 10.1097/01.aids.0000131393.76221.cc |
| format | Article |
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To determine the safety and efficacy of topical estrogen in preventing SIV vaginal transmission.
The non-human primate model of HIV vaginal transmission was used to assess vaginal estriol cream in ovariectomized macaques.
Twelve macaques were treated intravaginally with estriol and eight with placebo cream twice a week. The vaginal and systemic effects of estriol were determined by colposcopy and serum luteinizing hormone, levels of which would decline in the presence of systemic estrogen. After 5 weeks of therapy, the animals were challenged vaginally with pathogenic SIVmac251.
Vaginal estriol resulted in minimal serum estriol levels and had no effect on serum luteinizing hormone levels. Vaginal epithelia cornified and thickened significantly in response to estriol therapy. One of the estriol-treated animals became infected after this single challenge, while six of the control animals became infected (P = 0.0044).
These data demonstrate that topical vaginal estriol can strongly protect against SIV vaginal transmission, while having no detectable systemic effect. These results support the study of topical vaginal estriol in preventing HIV vaginal transmission in at-risk women.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/01.aids.0000131393.76221.cc</identifier><identifier>PMID: 15280774</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Administration, Topical ; AIDS/HIV ; Animals ; Antibodies, Viral - analysis ; Biological and medical sciences ; CD4 Lymphocyte Count ; Colposcopy - methods ; Disease Transmission, Infectious - prevention & control ; Epithelium - drug effects ; Estradiol - blood ; Estriol - administration & dosage ; Estriol - blood ; Female ; Human immunodeficiency virus ; Human viral diseases ; Infectious diseases ; Luteinizing Hormone - blood ; Macaca mulatta ; Medical sciences ; Ovariectomy ; RNA - blood ; Simian Acquired Immunodeficiency Syndrome - immunology ; Simian Acquired Immunodeficiency Syndrome - transmission ; Simian immunodeficiency virus ; Vagina - drug effects ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>AIDS (London), 2004-08, Vol.18 (12), p.1637-1643</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-87d0f0105f379fb5f1efbe6e54ecb08e9726192f0b81605d77f021ab817be6293</citedby><cites>FETCH-LOGICAL-c489t-87d0f0105f379fb5f1efbe6e54ecb08e9726192f0b81605d77f021ab817be6293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16013707$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15280774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SMITH, Stephen M</creatorcontrib><creatorcontrib>MEFFORD, Megan</creatorcontrib><creatorcontrib>SODORA, Donald</creatorcontrib><creatorcontrib>KLASE, Zachary</creatorcontrib><creatorcontrib>SINGH, Mahender</creatorcontrib><creatorcontrib>ALEXANDER, Nancy</creatorcontrib><creatorcontrib>HESS, David</creatorcontrib><creatorcontrib>MARX, Preston A</creatorcontrib><title>Topical estrogen protects against SIV vaginal transmission without evidence of systemic effect</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>Accumulating data suggest that the state of the vaginal epithelium affects a woman's risk of HIV vaginal transmission and several human and non-human primate studies have shown that the rate of HIV or SIV vaginal transmission is decreased when estrogen is dominant. Systemic estrogen can protect against SIV vaginal transmission.
To determine the safety and efficacy of topical estrogen in preventing SIV vaginal transmission.
The non-human primate model of HIV vaginal transmission was used to assess vaginal estriol cream in ovariectomized macaques.
Twelve macaques were treated intravaginally with estriol and eight with placebo cream twice a week. The vaginal and systemic effects of estriol were determined by colposcopy and serum luteinizing hormone, levels of which would decline in the presence of systemic estrogen. After 5 weeks of therapy, the animals were challenged vaginally with pathogenic SIVmac251.
Vaginal estriol resulted in minimal serum estriol levels and had no effect on serum luteinizing hormone levels. Vaginal epithelia cornified and thickened significantly in response to estriol therapy. One of the estriol-treated animals became infected after this single challenge, while six of the control animals became infected (P = 0.0044).
These data demonstrate that topical vaginal estriol can strongly protect against SIV vaginal transmission, while having no detectable systemic effect. These results support the study of topical vaginal estriol in preventing HIV vaginal transmission in at-risk women.</description><subject>Administration, Topical</subject><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Antibodies, Viral - analysis</subject><subject>Biological and medical sciences</subject><subject>CD4 Lymphocyte Count</subject><subject>Colposcopy - methods</subject><subject>Disease Transmission, Infectious - prevention & control</subject><subject>Epithelium - drug effects</subject><subject>Estradiol - blood</subject><subject>Estriol - administration & dosage</subject><subject>Estriol - blood</subject><subject>Female</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Infectious diseases</subject><subject>Luteinizing Hormone - blood</subject><subject>Macaca mulatta</subject><subject>Medical sciences</subject><subject>Ovariectomy</subject><subject>RNA - blood</subject><subject>Simian Acquired Immunodeficiency Syndrome - immunology</subject><subject>Simian Acquired Immunodeficiency Syndrome - transmission</subject><subject>Simian immunodeficiency virus</subject><subject>Vagina - drug effects</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpaTZp_0IRlPZmZ8ayvuiphH4EAjkk6bFClkdblV17a2lT8u-rJAt7rC6D4Jl3Zt6XsfcILYLV54CtT2NuoT4UKKxoteo6bEN4wVbYa9FIqfElW0GnbGOFhhN2mvPvyksw5jU7QdkZ0LpfsZ-38y4Fv-GUyzKvaeK7ZS4USuZ-7dOUC7-5_MHv_TpNlSqLn_I25Zzmif9N5de8L5zu00hTID5Hnh9yoW0KnGKsKm_Yq-g3md4e6hm7-_rl9uJ7c3X97fLi81UTemNLY_QIERBkFNrGQUakOJAi2VMYwJDVnULbRRgMKpCj1hE69PWnK9ZZccY-PuvW7f_s6y2uLhlos_ETzfvslNKyV2j-C6IB1QspK_jpGQzLnPNC0e2WtPXLg0Nwjzk4QPeYgzvm4J5ycCHU7neHMfthS-Ox92B8BT4cAJ-r_bH6GlI-cqpKatDiHxiFk9k</recordid><startdate>20040820</startdate><enddate>20040820</enddate><creator>SMITH, Stephen M</creator><creator>MEFFORD, Megan</creator><creator>SODORA, Donald</creator><creator>KLASE, Zachary</creator><creator>SINGH, Mahender</creator><creator>ALEXANDER, Nancy</creator><creator>HESS, David</creator><creator>MARX, Preston A</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20040820</creationdate><title>Topical estrogen protects against SIV vaginal transmission without evidence of systemic effect</title><author>SMITH, Stephen M ; MEFFORD, Megan ; SODORA, Donald ; KLASE, Zachary ; SINGH, Mahender ; ALEXANDER, Nancy ; HESS, David ; MARX, Preston A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-87d0f0105f379fb5f1efbe6e54ecb08e9726192f0b81605d77f021ab817be6293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Administration, Topical</topic><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Antibodies, Viral - analysis</topic><topic>Biological and medical sciences</topic><topic>CD4 Lymphocyte Count</topic><topic>Colposcopy - methods</topic><topic>Disease Transmission, Infectious - prevention & control</topic><topic>Epithelium - drug effects</topic><topic>Estradiol - blood</topic><topic>Estriol - administration & dosage</topic><topic>Estriol - blood</topic><topic>Female</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Infectious diseases</topic><topic>Luteinizing Hormone - blood</topic><topic>Macaca mulatta</topic><topic>Medical sciences</topic><topic>Ovariectomy</topic><topic>RNA - blood</topic><topic>Simian Acquired Immunodeficiency Syndrome - immunology</topic><topic>Simian Acquired Immunodeficiency Syndrome - transmission</topic><topic>Simian immunodeficiency virus</topic><topic>Vagina - drug effects</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SMITH, Stephen M</creatorcontrib><creatorcontrib>MEFFORD, Megan</creatorcontrib><creatorcontrib>SODORA, Donald</creatorcontrib><creatorcontrib>KLASE, Zachary</creatorcontrib><creatorcontrib>SINGH, Mahender</creatorcontrib><creatorcontrib>ALEXANDER, Nancy</creatorcontrib><creatorcontrib>HESS, David</creatorcontrib><creatorcontrib>MARX, Preston A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SMITH, Stephen M</au><au>MEFFORD, Megan</au><au>SODORA, Donald</au><au>KLASE, Zachary</au><au>SINGH, Mahender</au><au>ALEXANDER, Nancy</au><au>HESS, David</au><au>MARX, Preston A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topical estrogen protects against SIV vaginal transmission without evidence of systemic effect</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2004-08-20</date><risdate>2004</risdate><volume>18</volume><issue>12</issue><spage>1637</spage><epage>1643</epage><pages>1637-1643</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>Accumulating data suggest that the state of the vaginal epithelium affects a woman's risk of HIV vaginal transmission and several human and non-human primate studies have shown that the rate of HIV or SIV vaginal transmission is decreased when estrogen is dominant. Systemic estrogen can protect against SIV vaginal transmission.
To determine the safety and efficacy of topical estrogen in preventing SIV vaginal transmission.
The non-human primate model of HIV vaginal transmission was used to assess vaginal estriol cream in ovariectomized macaques.
Twelve macaques were treated intravaginally with estriol and eight with placebo cream twice a week. The vaginal and systemic effects of estriol were determined by colposcopy and serum luteinizing hormone, levels of which would decline in the presence of systemic estrogen. After 5 weeks of therapy, the animals were challenged vaginally with pathogenic SIVmac251.
Vaginal estriol resulted in minimal serum estriol levels and had no effect on serum luteinizing hormone levels. Vaginal epithelia cornified and thickened significantly in response to estriol therapy. One of the estriol-treated animals became infected after this single challenge, while six of the control animals became infected (P = 0.0044).
These data demonstrate that topical vaginal estriol can strongly protect against SIV vaginal transmission, while having no detectable systemic effect. These results support the study of topical vaginal estriol in preventing HIV vaginal transmission in at-risk women.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>15280774</pmid><doi>10.1097/01.aids.0000131393.76221.cc</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0269-9370 |
| ispartof | AIDS (London), 2004-08, Vol.18 (12), p.1637-1643 |
| issn | 0269-9370 1473-5571 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66754618 |
| source | Journals@Ovid Complete - AutoHoldings; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Administration, Topical AIDS/HIV Animals Antibodies, Viral - analysis Biological and medical sciences CD4 Lymphocyte Count Colposcopy - methods Disease Transmission, Infectious - prevention & control Epithelium - drug effects Estradiol - blood Estriol - administration & dosage Estriol - blood Female Human immunodeficiency virus Human viral diseases Infectious diseases Luteinizing Hormone - blood Macaca mulatta Medical sciences Ovariectomy RNA - blood Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - transmission Simian immunodeficiency virus Vagina - drug effects Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Topical estrogen protects against SIV vaginal transmission without evidence of systemic effect |
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