Posttransplant lymphoproliferative disease after allogeneic transplantation of the spleen in miniature swine
Spleen transplantation (SpTx) was performed in miniature swine across full major histocompatibility complex barriers to study the tolerogenic effect of the spleen. This study describes the development of posttransplant lymphoproliferative disease (PTLD) after allogeneic SpTx. Recipient pigs underwen...
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| Veröffentlicht in: | Transplantation 2004-07, Vol.78 (2), p.286-291 |
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| creator | DOR, Frank J. M. F DOUCETTE, Karen E COOPER, David K. C HUANG, Christene A MUELLER, Nicolas J WILKINSON, Robert A BAJWA, Junaid A MCMORROW, Isabel M TSENG, Yau-Lin KUWAKI, Kenji HOUSER, Stuart L FISHMAN, Jay A |
| description | Spleen transplantation (SpTx) was performed in miniature swine across full major histocompatibility complex barriers to study the tolerogenic effect of the spleen. This study describes the development of posttransplant lymphoproliferative disease (PTLD) after allogeneic SpTx. Recipient pigs underwent whole body irradiation (100 cGy), thymic irradiation (700 cGy), and native splenectomy (day 0), and received a 45-day course of intravenous cyclosporine (trough level 400-800 ng/ml). After SpTx, two of seven pigs developed PTLD (1 donor-type, 1 host-type). These two pigs had greater T cell depletion and higher trough levels of cyclosporine. Early changes that occurred prior to the development of clinical features of PTLD were increased porcine lymphotropic herpesvirus-1 viral loads in blood and tissues, and increased numbers of leukocytes, B cells, and total serum IgM. PTLD can occur after allogeneic SpTx in swine. This model may be useful in studies of the pathogenesis of PTLD. |
| doi_str_mv | 10.1097/01.TP.0000128342.64240.CF |
| format | Article |
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M. F ; DOUCETTE, Karen E ; COOPER, David K. C ; HUANG, Christene A ; MUELLER, Nicolas J ; WILKINSON, Robert A ; BAJWA, Junaid A ; MCMORROW, Isabel M ; TSENG, Yau-Lin ; KUWAKI, Kenji ; HOUSER, Stuart L ; FISHMAN, Jay A</creator><creatorcontrib>DOR, Frank J. M. F ; DOUCETTE, Karen E ; COOPER, David K. C ; HUANG, Christene A ; MUELLER, Nicolas J ; WILKINSON, Robert A ; BAJWA, Junaid A ; MCMORROW, Isabel M ; TSENG, Yau-Lin ; KUWAKI, Kenji ; HOUSER, Stuart L ; FISHMAN, Jay A</creatorcontrib><description>Spleen transplantation (SpTx) was performed in miniature swine across full major histocompatibility complex barriers to study the tolerogenic effect of the spleen. This study describes the development of posttransplant lymphoproliferative disease (PTLD) after allogeneic SpTx. Recipient pigs underwent whole body irradiation (100 cGy), thymic irradiation (700 cGy), and native splenectomy (day 0), and received a 45-day course of intravenous cyclosporine (trough level 400-800 ng/ml). After SpTx, two of seven pigs developed PTLD (1 donor-type, 1 host-type). These two pigs had greater T cell depletion and higher trough levels of cyclosporine. Early changes that occurred prior to the development of clinical features of PTLD were increased porcine lymphotropic herpesvirus-1 viral loads in blood and tissues, and increased numbers of leukocytes, B cells, and total serum IgM. PTLD can occur after allogeneic SpTx in swine. This model may be useful in studies of the pathogenesis of PTLD.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/01.TP.0000128342.64240.CF</identifier><identifier>PMID: 15280692</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Animals ; Biological and medical sciences ; Combined surgery. Multiple transplantations ; Disease Models, Animal ; Histocompatibility Testing ; Leukocyte Count ; Lymphoproliferative Disorders - diagnosis ; Medical sciences ; Postoperative Complications - diagnosis ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Swine ; Swine, Miniature ; Transplantation, Homologous - adverse effects</subject><ispartof>Transplantation, 2004-07, Vol.78 (2), p.286-291</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-30179f4bf7d95f666c25a9b64d27d5651c50ab4783cf07928a516806797e6183</citedby><cites>FETCH-LOGICAL-c481t-30179f4bf7d95f666c25a9b64d27d5651c50ab4783cf07928a516806797e6183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15978736$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15280692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DOR, Frank J. M. F</creatorcontrib><creatorcontrib>DOUCETTE, Karen E</creatorcontrib><creatorcontrib>COOPER, David K. C</creatorcontrib><creatorcontrib>HUANG, Christene A</creatorcontrib><creatorcontrib>MUELLER, Nicolas J</creatorcontrib><creatorcontrib>WILKINSON, Robert A</creatorcontrib><creatorcontrib>BAJWA, Junaid A</creatorcontrib><creatorcontrib>MCMORROW, Isabel M</creatorcontrib><creatorcontrib>TSENG, Yau-Lin</creatorcontrib><creatorcontrib>KUWAKI, Kenji</creatorcontrib><creatorcontrib>HOUSER, Stuart L</creatorcontrib><creatorcontrib>FISHMAN, Jay A</creatorcontrib><title>Posttransplant lymphoproliferative disease after allogeneic transplantation of the spleen in miniature swine</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Spleen transplantation (SpTx) was performed in miniature swine across full major histocompatibility complex barriers to study the tolerogenic effect of the spleen. This study describes the development of posttransplant lymphoproliferative disease (PTLD) after allogeneic SpTx. Recipient pigs underwent whole body irradiation (100 cGy), thymic irradiation (700 cGy), and native splenectomy (day 0), and received a 45-day course of intravenous cyclosporine (trough level 400-800 ng/ml). After SpTx, two of seven pigs developed PTLD (1 donor-type, 1 host-type). These two pigs had greater T cell depletion and higher trough levels of cyclosporine. Early changes that occurred prior to the development of clinical features of PTLD were increased porcine lymphotropic herpesvirus-1 viral loads in blood and tissues, and increased numbers of leukocytes, B cells, and total serum IgM. PTLD can occur after allogeneic SpTx in swine. This model may be useful in studies of the pathogenesis of PTLD.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Combined surgery. Multiple transplantations</subject><subject>Disease Models, Animal</subject><subject>Histocompatibility Testing</subject><subject>Leukocyte Count</subject><subject>Lymphoproliferative Disorders - diagnosis</subject><subject>Medical sciences</subject><subject>Postoperative Complications - diagnosis</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Swine</subject><subject>Swine, Miniature</subject><subject>Transplantation, Homologous - adverse effects</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P0zAQhi0EYsvCX0DmALcET_wVH1FFAWkleujdcp0xa-QkxXZB--8xbKVyYy4jjZ53vl5C3gDrgRn9nkF_2PesBQwjF0OvxCBYv909IRuQXHSKjewp2TAmoAPO9Q15Ucr3xkuu9XNyA3IYmTLDhqT9WmrNbimn5JZK08N8ul9PeU0xYHY1_kQ6xYKuIHWhYqYupfUbLhg9veoauC50DbTeI20lxIXGhc5xia6ec6v9igu-JM-CSwVfXfItOew-Hrafu7uvn75sP9x1XoxQO85AmyCOQU9GBqWUH6QzRyWmQU9SSfCSuaPQI_eBaTOMToJq92ijUcHIb8m7x7btjB9nLNXOsXhMbVFcz8UqpSU3o_4vCFqDFIw30DyCPq-lZAz2lOPs8oMFZv9YYhnYw95eLbF_LbHbXdO-vgw5H2ecrsqLBw14ewFc8S6F9lQfyz-c0W1XxX8D14KWYA</recordid><startdate>20040727</startdate><enddate>20040727</enddate><creator>DOR, Frank J. M. F</creator><creator>DOUCETTE, Karen E</creator><creator>COOPER, David K. 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C ; HUANG, Christene A ; MUELLER, Nicolas J ; WILKINSON, Robert A ; BAJWA, Junaid A ; MCMORROW, Isabel M ; TSENG, Yau-Lin ; KUWAKI, Kenji ; HOUSER, Stuart L ; FISHMAN, Jay A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-30179f4bf7d95f666c25a9b64d27d5651c50ab4783cf07928a516806797e6183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Combined surgery. Multiple transplantations</topic><topic>Disease Models, Animal</topic><topic>Histocompatibility Testing</topic><topic>Leukocyte Count</topic><topic>Lymphoproliferative Disorders - diagnosis</topic><topic>Medical sciences</topic><topic>Postoperative Complications - diagnosis</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Swine</topic><topic>Swine, Miniature</topic><topic>Transplantation, Homologous - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DOR, Frank J. M. F</creatorcontrib><creatorcontrib>DOUCETTE, Karen E</creatorcontrib><creatorcontrib>COOPER, David K. 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M. F</au><au>DOUCETTE, Karen E</au><au>COOPER, David K. C</au><au>HUANG, Christene A</au><au>MUELLER, Nicolas J</au><au>WILKINSON, Robert A</au><au>BAJWA, Junaid A</au><au>MCMORROW, Isabel M</au><au>TSENG, Yau-Lin</au><au>KUWAKI, Kenji</au><au>HOUSER, Stuart L</au><au>FISHMAN, Jay A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Posttransplant lymphoproliferative disease after allogeneic transplantation of the spleen in miniature swine</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2004-07-27</date><risdate>2004</risdate><volume>78</volume><issue>2</issue><spage>286</spage><epage>291</epage><pages>286-291</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Spleen transplantation (SpTx) was performed in miniature swine across full major histocompatibility complex barriers to study the tolerogenic effect of the spleen. This study describes the development of posttransplant lymphoproliferative disease (PTLD) after allogeneic SpTx. Recipient pigs underwent whole body irradiation (100 cGy), thymic irradiation (700 cGy), and native splenectomy (day 0), and received a 45-day course of intravenous cyclosporine (trough level 400-800 ng/ml). After SpTx, two of seven pigs developed PTLD (1 donor-type, 1 host-type). These two pigs had greater T cell depletion and higher trough levels of cyclosporine. Early changes that occurred prior to the development of clinical features of PTLD were increased porcine lymphotropic herpesvirus-1 viral loads in blood and tissues, and increased numbers of leukocytes, B cells, and total serum IgM. PTLD can occur after allogeneic SpTx in swine. This model may be useful in studies of the pathogenesis of PTLD.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>15280692</pmid><doi>10.1097/01.TP.0000128342.64240.CF</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences Combined surgery. Multiple transplantations Disease Models, Animal Histocompatibility Testing Leukocyte Count Lymphoproliferative Disorders - diagnosis Medical sciences Postoperative Complications - diagnosis Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Swine Swine, Miniature Transplantation, Homologous - adverse effects |
| title | Posttransplant lymphoproliferative disease after allogeneic transplantation of the spleen in miniature swine |
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