Inhibition of pancreatic cancer cell proliferation by propranolol occurs through apoptosis induction: the study of beta-adrenoceptor antagonist's anticancer effect in pancreatic cancer cell

Propranolol inhibited pancreatic cancer cell proliferation by blocking signaling through the beta-adrenoceptor. We hypothesized that propranolol may suppress pancreatic cancer cell growth through induction of apoptosis. The beta-adrenoceptor antagonist propranolol, beta1-adrenoceptor antagonist meto...

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Veröffentlicht in:	Pancreas 2009-01, Vol.38 (1), p.94-100
Hauptverfasser:	Zhang, Dong, Ma, Qingyong, Shen, Sugang, Hu, Hengtong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-1 Receptor Antagonists Adrenergic beta-2 Receptor Antagonists Adrenergic beta-Antagonists - pharmacology Annexin A5 - metabolism Antineoplastic Agents - pharmacology Apoptosis - drug effects Butoxamine - pharmacology Caspase 3 - metabolism Caspase 8 - metabolism Caspase 9 - metabolism Cell Line, Tumor Cell Proliferation - drug effects Dose-Response Relationship, Drug Gene Expression Regulation, Neoplastic Humans Metoprolol - pharmacology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Propranolol - pharmacology Receptors, Adrenergic, beta-1 - genetics Receptors, Adrenergic, beta-1 - metabolism Receptors, Adrenergic, beta-2 - genetics Receptors, Adrenergic, beta-2 - metabolism RNA, Messenger - metabolism
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