Quantitative structure-activity relationships within a homologous series of 7-alkoxyresorufins exhibiting activity towards CYP1A and CYP2B enzymes: molecular modelling studies on key members of the resorufin series with CYP2C5-derived models of human CYP1A1, CYP1A2, CYP2B6 and CYP3A4

1. The results of quantitative structure-activity relationships (QSARs) within a homologous series of 7-n-alkoxyresorufins are reported. They are consistent with homology modelling of the relevant P450s involved in their metabolism. 2. QSARs were generated for activities involving CYP1A and CYP2B en...

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Veröffentlicht in:	Xenobiotica 2004-06, Vol.34 (6), p.501-513
Hauptverfasser:	Lewis, David F. V., Lake, Brian G., Dickins, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - metabolism Humans Models, Molecular Molecular Conformation Oxazines - chemistry Oxazines - pharmacology Quantitative Structure-Activity Relationship
Online-Zugang:	Volltext
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