High-dose intravenous vitamin C is not associated with an increase of pro-oxidative biomarkers

Objective: High-dose vitamin C therapy might mediate beneficial clinical effects by counteracting reactive oxygen species. However, concerns are raised whether this approach might provoke diametrical (ie pro-oxidative) effects. The objective was to determine ascorbyl free radical (AFR) concentration...

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Veröffentlicht in:	European journal of clinical nutrition 2004-08, Vol.58 (8), p.1151-1158
Hauptverfasser:	Muhlhofer, A, Mrosek, S, Schlegel, B, Trommer, W, Rozario, F, Bohles, H, Schremmer, D, Zoller, W.G, Biesalski, H.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antioxidants - administration & dosage Antioxidants - pharmacokinetics Ascorbic acid Ascorbic Acid - administration & dosage Ascorbic Acid - blood Ascorbic Acid - pharmacokinetics Biological and medical sciences Biomarkers Clinical nutrition Cross-Over Studies Dose-Response Relationship, Drug Fasting Free Radical Scavengers - administration & dosage Free Radical Scavengers - blood Free Radical Scavengers - pharmacokinetics Free radicals Free Radicals - blood General and cellular metabolism. Vitamins Guanosine - analogs & derivatives Guanosine - urine Humans Infusions, Intravenous Intravenous administration Kinetics Male Medical sciences Oxidation Oxidation-Reduction Oxidative Stress Pharmacology. Drug treatments Prospective Studies Reactive oxygen species Reactive Oxygen Species - antagonists & inhibitors Thiobarbituric acid Thiobarbituric Acid Reactive Substances - analysis Tocopherol Vitamin C Vitamin E
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