High-dose intravenous vitamin C is not associated with an increase of pro-oxidative biomarkers
Objective: High-dose vitamin C therapy might mediate beneficial clinical effects by counteracting reactive oxygen species. However, concerns are raised whether this approach might provoke diametrical (ie pro-oxidative) effects. The objective was to determine ascorbyl free radical (AFR) concentration...
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| Veröffentlicht in: | European journal of clinical nutrition 2004-08, Vol.58 (8), p.1151-1158 |
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| creator | Muhlhofer, A Mrosek, S Schlegel, B Trommer, W Rozario, F Bohles, H Schremmer, D Zoller, W.G Biesalski, H.K |
| description | Objective: High-dose vitamin C therapy might mediate beneficial clinical effects by counteracting reactive oxygen species. However, concerns are raised whether this approach might provoke diametrical (ie pro-oxidative) effects. The objective was to determine ascorbyl free radical (AFR) concentrations and potential variables of pro-oxidative damage. Design: Crossover study; six healthy males received daily infusions of 750 or 7500 mg vitamin C for six consecutive days. Fasting concentrations of vitamin C and AFR were determined daily. On day 1, concentrations of vitamin C and AFR were measured at 0.25, 0.5, 1, 2, 4 and 8 h post infusion. Plasma concentrations of thiobarbituric acid-reactive substances (TBARS), tocopherol and urine concentrations of 8-oxoguanosine were determined on days 1 and 6. Results: Kinetic studies on day 1 showed that concentrations of vitamin C and AFR displayed parallel dose- and time-dependent kinetics and elimination was highly efficient. Vitamin C and AFR fasting concentrations on days 2-6 were slightly above the baseline, suggesting new, stable steady states. TBARS decreased in both groups, whereas tocopherol and 8-oxoguanosine concentrations remained unchanged. Conclusion: Kinetics of AFR largely depend on plasma vitamin C concentrations and AFR is eliminated efficiently. Our data do not support induction of pro-oxidative effects in healthy volunteers given intravenous high-dose vitamin C. |
| doi_str_mv | 10.1038/sj.ejcn.1601943 |
| format | Article |
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However, concerns are raised whether this approach might provoke diametrical (ie pro-oxidative) effects. The objective was to determine ascorbyl free radical (AFR) concentrations and potential variables of pro-oxidative damage. Design: Crossover study; six healthy males received daily infusions of 750 or 7500 mg vitamin C for six consecutive days. Fasting concentrations of vitamin C and AFR were determined daily. On day 1, concentrations of vitamin C and AFR were measured at 0.25, 0.5, 1, 2, 4 and 8 h post infusion. Plasma concentrations of thiobarbituric acid-reactive substances (TBARS), tocopherol and urine concentrations of 8-oxoguanosine were determined on days 1 and 6. Results: Kinetic studies on day 1 showed that concentrations of vitamin C and AFR displayed parallel dose- and time-dependent kinetics and elimination was highly efficient. Vitamin C and AFR fasting concentrations on days 2-6 were slightly above the baseline, suggesting new, stable steady states. TBARS decreased in both groups, whereas tocopherol and 8-oxoguanosine concentrations remained unchanged. Conclusion: Kinetics of AFR largely depend on plasma vitamin C concentrations and AFR is eliminated efficiently. Our data do not support induction of pro-oxidative effects in healthy volunteers given intravenous high-dose vitamin C.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/sj.ejcn.1601943</identifier><identifier>PMID: 15054428</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Adult ; Antioxidants - administration & dosage ; Antioxidants - pharmacokinetics ; Ascorbic acid ; Ascorbic Acid - administration & dosage ; Ascorbic Acid - blood ; Ascorbic Acid - pharmacokinetics ; Biological and medical sciences ; Biomarkers ; Clinical nutrition ; Cross-Over Studies ; Dose-Response Relationship, Drug ; Fasting ; Free Radical Scavengers - administration & dosage ; Free Radical Scavengers - blood ; Free Radical Scavengers - pharmacokinetics ; Free radicals ; Free Radicals - blood ; General and cellular metabolism. Vitamins ; Guanosine - analogs & derivatives ; Guanosine - urine ; Humans ; Infusions, Intravenous ; Intravenous administration ; Kinetics ; Male ; Medical sciences ; Oxidation ; Oxidation-Reduction ; Oxidative Stress ; Pharmacology. Drug treatments ; Prospective Studies ; Reactive oxygen species ; Reactive Oxygen Species - antagonists & inhibitors ; Thiobarbituric acid ; Thiobarbituric Acid Reactive Substances - analysis ; Tocopherol ; Vitamin C ; Vitamin E</subject><ispartof>European journal of clinical nutrition, 2004-08, Vol.58 (8), p.1151-1158</ispartof><rights>2004 INIST-CNRS</rights><rights>COPYRIGHT 2004 Nature Publishing Group</rights><rights>Copyright Macmillan Journals Ltd. Aug 2004</rights><rights>Nature Publishing Group 2004.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-80d3363b1ae8c2b310cee01ccd47a0c48b76d1fff8e2f49f13fbc592587b058d3</citedby><cites>FETCH-LOGICAL-c464t-80d3363b1ae8c2b310cee01ccd47a0c48b76d1fff8e2f49f13fbc592587b058d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,2728,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15972933$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15054428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muhlhofer, A</creatorcontrib><creatorcontrib>Mrosek, S</creatorcontrib><creatorcontrib>Schlegel, B</creatorcontrib><creatorcontrib>Trommer, W</creatorcontrib><creatorcontrib>Rozario, F</creatorcontrib><creatorcontrib>Bohles, H</creatorcontrib><creatorcontrib>Schremmer, D</creatorcontrib><creatorcontrib>Zoller, W.G</creatorcontrib><creatorcontrib>Biesalski, H.K</creatorcontrib><title>High-dose intravenous vitamin C is not associated with an increase of pro-oxidative biomarkers</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><description>Objective: High-dose vitamin C therapy might mediate beneficial clinical effects by counteracting reactive oxygen species. However, concerns are raised whether this approach might provoke diametrical (ie pro-oxidative) effects. The objective was to determine ascorbyl free radical (AFR) concentrations and potential variables of pro-oxidative damage. Design: Crossover study; six healthy males received daily infusions of 750 or 7500 mg vitamin C for six consecutive days. Fasting concentrations of vitamin C and AFR were determined daily. On day 1, concentrations of vitamin C and AFR were measured at 0.25, 0.5, 1, 2, 4 and 8 h post infusion. Plasma concentrations of thiobarbituric acid-reactive substances (TBARS), tocopherol and urine concentrations of 8-oxoguanosine were determined on days 1 and 6. Results: Kinetic studies on day 1 showed that concentrations of vitamin C and AFR displayed parallel dose- and time-dependent kinetics and elimination was highly efficient. Vitamin C and AFR fasting concentrations on days 2-6 were slightly above the baseline, suggesting new, stable steady states. TBARS decreased in both groups, whereas tocopherol and 8-oxoguanosine concentrations remained unchanged. Conclusion: Kinetics of AFR largely depend on plasma vitamin C concentrations and AFR is eliminated efficiently. Our data do not support induction of pro-oxidative effects in healthy volunteers given intravenous high-dose vitamin C.</description><subject>Adult</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - pharmacokinetics</subject><subject>Ascorbic acid</subject><subject>Ascorbic Acid - administration & dosage</subject><subject>Ascorbic Acid - blood</subject><subject>Ascorbic Acid - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Clinical nutrition</subject><subject>Cross-Over Studies</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fasting</subject><subject>Free Radical Scavengers - administration & dosage</subject><subject>Free Radical Scavengers - blood</subject><subject>Free Radical Scavengers - pharmacokinetics</subject><subject>Free radicals</subject><subject>Free Radicals - blood</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Guanosine - analogs & derivatives</subject><subject>Guanosine - urine</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Intravenous administration</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oxidation</subject><subject>Oxidation-Reduction</subject><subject>Oxidative Stress</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - antagonists & inhibitors</subject><subject>Thiobarbituric acid</subject><subject>Thiobarbituric Acid Reactive Substances - analysis</subject><subject>Tocopherol</subject><subject>Vitamin C</subject><subject>Vitamin E</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kkFv1DAQhSMEokvhzAmIQPSWre04dnKsVkCRKnGAXrEmznjXS9YutrPAv8errGhBRT5Y8nzveTx-RfGckiUldXset0vcarekgtCO1w-KBeVSVI3g5GGxIF3Dq5oQeVI8iXFLSC5K9rg4oQ1pOGftovh6adebavARS-tSgD06P8VybxPsrCtXpY2l86mEGL22kHAof9i0KcFlXgeELPSmvAm-8j_tAMnuseyt30H4hiE-LR4ZGCM-O-6nxfX7d19Wl9XVpw8fVxdXleaCp6olQ12LuqeArWZ9TYlGJFTrgUsgmre9FAM1xrTIDO8MrU2vm441rexJ0w71aXE2--ZGvk8Yk9rZqHEcwWF-jxJCNkxSlsE3_4BbPwWXe1NMcCY5z6PJ1Ov_UrQTguYBZqiaoTWMqKwzPs9Pr9FhgNE7NDYfX9CukQ1t6cF0eQ-f14A7q-8VnN0RbBDGtIl-nJL1Lv4Nns-gDj7GgEbdBJt_4JeiRB1youJWHXKijjnJipfHB079Dodb_hiMDLw9AhA1jCaA0zbe4TrJuvpg9GLmHKQp4C3w56JXc92AV7AO2eP6MyM0p7Ljos0evwEmUNeV</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>Muhlhofer, A</creator><creator>Mrosek, S</creator><creator>Schlegel, B</creator><creator>Trommer, W</creator><creator>Rozario, F</creator><creator>Bohles, H</creator><creator>Schremmer, D</creator><creator>Zoller, W.G</creator><creator>Biesalski, H.K</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20040801</creationdate><title>High-dose intravenous vitamin C is not associated with an increase of pro-oxidative biomarkers</title><author>Muhlhofer, A ; Mrosek, S ; Schlegel, B ; Trommer, W ; Rozario, F ; Bohles, H ; Schremmer, D ; Zoller, W.G ; Biesalski, H.K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-80d3363b1ae8c2b310cee01ccd47a0c48b76d1fff8e2f49f13fbc592587b058d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - pharmacokinetics</topic><topic>Ascorbic acid</topic><topic>Ascorbic Acid - administration & dosage</topic><topic>Ascorbic Acid - blood</topic><topic>Ascorbic Acid - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Clinical nutrition</topic><topic>Cross-Over Studies</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fasting</topic><topic>Free Radical Scavengers - administration & dosage</topic><topic>Free Radical Scavengers - blood</topic><topic>Free Radical Scavengers - pharmacokinetics</topic><topic>Free radicals</topic><topic>Free Radicals - blood</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Guanosine - analogs & derivatives</topic><topic>Guanosine - urine</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Intravenous administration</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oxidation</topic><topic>Oxidation-Reduction</topic><topic>Oxidative Stress</topic><topic>Pharmacology. 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However, concerns are raised whether this approach might provoke diametrical (ie pro-oxidative) effects. The objective was to determine ascorbyl free radical (AFR) concentrations and potential variables of pro-oxidative damage. Design: Crossover study; six healthy males received daily infusions of 750 or 7500 mg vitamin C for six consecutive days. Fasting concentrations of vitamin C and AFR were determined daily. On day 1, concentrations of vitamin C and AFR were measured at 0.25, 0.5, 1, 2, 4 and 8 h post infusion. Plasma concentrations of thiobarbituric acid-reactive substances (TBARS), tocopherol and urine concentrations of 8-oxoguanosine were determined on days 1 and 6. Results: Kinetic studies on day 1 showed that concentrations of vitamin C and AFR displayed parallel dose- and time-dependent kinetics and elimination was highly efficient. Vitamin C and AFR fasting concentrations on days 2-6 were slightly above the baseline, suggesting new, stable steady states. TBARS decreased in both groups, whereas tocopherol and 8-oxoguanosine concentrations remained unchanged. Conclusion: Kinetics of AFR largely depend on plasma vitamin C concentrations and AFR is eliminated efficiently. Our data do not support induction of pro-oxidative effects in healthy volunteers given intravenous high-dose vitamin C.</abstract><cop>Basingstoke</cop><pub>Nature Publishing</pub><pmid>15054428</pmid><doi>10.1038/sj.ejcn.1601943</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of clinical nutrition, 2004-08, Vol.58 (8), p.1151-1158 |
| issn | 0954-3007 1476-5640 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Nature Journals Online; Alma/SFX Local Collection |
| subjects | Adult Antioxidants - administration & dosage Antioxidants - pharmacokinetics Ascorbic acid Ascorbic Acid - administration & dosage Ascorbic Acid - blood Ascorbic Acid - pharmacokinetics Biological and medical sciences Biomarkers Clinical nutrition Cross-Over Studies Dose-Response Relationship, Drug Fasting Free Radical Scavengers - administration & dosage Free Radical Scavengers - blood Free Radical Scavengers - pharmacokinetics Free radicals Free Radicals - blood General and cellular metabolism. Vitamins Guanosine - analogs & derivatives Guanosine - urine Humans Infusions, Intravenous Intravenous administration Kinetics Male Medical sciences Oxidation Oxidation-Reduction Oxidative Stress Pharmacology. Drug treatments Prospective Studies Reactive oxygen species Reactive Oxygen Species - antagonists & inhibitors Thiobarbituric acid Thiobarbituric Acid Reactive Substances - analysis Tocopherol Vitamin C Vitamin E |
| title | High-dose intravenous vitamin C is not associated with an increase of pro-oxidative biomarkers |
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