Proline Effect on the Thermostability and Slow Unfolding of a Hyperthermophilic Protein

Ribonuclease HII from hyperthermophile Thermococcus kodakaraensis (Tk-RNase HII) is a robust monomeric protein under kinetic control, which possesses some proline residues at the N-terminal of α-helices. Proline residue at the N-terminal of an α-helix is thought to stabilize a protein. In this work,...

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