Stimulus intensity dependence of cerebral blood volume changes in left frontal lobe by low-frequency rTMS to right frontal lobe: A near-infrared spectroscopy study
Repetitive transcranial magnetic stimulation (rTMS) has recently been widely employed for the investigation of brain function and treatment of psychiatric and neurological disorders. Although high and low stimulation frequencies are assumed to activate and deactivate brain function, respectively, th...
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| Veröffentlicht in: | Neuroscience research 2009, Vol.63 (1), p.47-51 |
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| creator | Aoyama, Yoshiyuki Hanaoka, Naoki Kameyama, Masaki Suda, Masashi Sato, Toshimasa Song, Mingqiao Fukuda, Masato Mikuni, Masahiko |
| description | Repetitive transcranial magnetic stimulation (rTMS) has recently been widely employed for the investigation of brain function and treatment of psychiatric and neurological disorders. Although high and low stimulation frequencies are assumed to activate and deactivate brain function, respectively, the optimal parameters of rTMS for treatment of depression have been determined only on the basis of their clinical efficacy. In this study, we administered a 60-s low-frequency rTMS of three grades low intensities over the right dorsolateral prefrontal cortex (DLPFC) in 10 healthy volunteers, and monitored functional changes of the contralateral DLPFC by near-infrared spectroscopy (NIRS) during and immediately after rTMS. Obtained results demonstrated significant [oxy-Hb] decreases during rTMS, and significant differences in the time courses of [oxy-Hb] changes among three stimulus intensities, that is, [oxy-Hb] decreases were most prominent during the latter half of the stimulation and the first 30
s of poststimulation only at 15
mm condition (58% intensity). These results suggest that monitoring of brain functional changes due to rTMS using NIRS is useful for elucidating the brain mechanisms underlying the clinical effects of rTMS, and the effects of rTMS over contralateral DLPFC are obtained if the stimulus intensities are more than one-half of the motor thresholds. |
| doi_str_mv | 10.1016/j.neures.2008.10.003 |
| format | Article |
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s of poststimulation only at 15
mm condition (58% intensity). These results suggest that monitoring of brain functional changes due to rTMS using NIRS is useful for elucidating the brain mechanisms underlying the clinical effects of rTMS, and the effects of rTMS over contralateral DLPFC are obtained if the stimulus intensities are more than one-half of the motor thresholds.</description><identifier>ISSN: 0168-0102</identifier><identifier>EISSN: 1872-8111</identifier><identifier>DOI: 10.1016/j.neures.2008.10.003</identifier><identifier>PMID: 18992287</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adult ; Cerebrovascular Circulation - physiology ; Cerebrovascular Circulation - radiation effects ; Depression ; Depressive Disorder - physiopathology ; Depressive Disorder - therapy ; Energy Metabolism - physiology ; Energy Metabolism - radiation effects ; Evoked Potentials, Motor - physiology ; Female ; Functional Laterality - physiology ; Functional Laterality - radiation effects ; Hemoglobin concentration ; Humans ; Magnetic stimulation ; Male ; Middle Aged ; Near-infrared spectroscopy ; Oxygen Consumption - physiology ; Oxygen Consumption - radiation effects ; Oxyhemoglobins - analysis ; Oxyhemoglobins - metabolism ; Prefrontal Cortex - blood supply ; Prefrontal Cortex - physiology ; Prefrontal Cortex - radiation effects ; rTMS ; Spectroscopy, Near-Infrared - methods ; Therapy ; Time Factors ; Transcranial Magnetic Stimulation - methods</subject><ispartof>Neuroscience research, 2009, Vol.63 (1), p.47-51</ispartof><rights>2008 Elsevier Ireland Ltd and the Japan Neuroscience Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-6a0cf707c96a33f2f8411de8d4e006427c5f8c0cf0dc8278f4f8789ca69b8743</citedby><cites>FETCH-LOGICAL-c444t-6a0cf707c96a33f2f8411de8d4e006427c5f8c0cf0dc8278f4f8789ca69b8743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neures.2008.10.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,4025,27925,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18992287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aoyama, Yoshiyuki</creatorcontrib><creatorcontrib>Hanaoka, Naoki</creatorcontrib><creatorcontrib>Kameyama, Masaki</creatorcontrib><creatorcontrib>Suda, Masashi</creatorcontrib><creatorcontrib>Sato, Toshimasa</creatorcontrib><creatorcontrib>Song, Mingqiao</creatorcontrib><creatorcontrib>Fukuda, Masato</creatorcontrib><creatorcontrib>Mikuni, Masahiko</creatorcontrib><title>Stimulus intensity dependence of cerebral blood volume changes in left frontal lobe by low-frequency rTMS to right frontal lobe: A near-infrared spectroscopy study</title><title>Neuroscience research</title><addtitle>Neurosci Res</addtitle><description>Repetitive transcranial magnetic stimulation (rTMS) has recently been widely employed for the investigation of brain function and treatment of psychiatric and neurological disorders. Although high and low stimulation frequencies are assumed to activate and deactivate brain function, respectively, the optimal parameters of rTMS for treatment of depression have been determined only on the basis of their clinical efficacy. In this study, we administered a 60-s low-frequency rTMS of three grades low intensities over the right dorsolateral prefrontal cortex (DLPFC) in 10 healthy volunteers, and monitored functional changes of the contralateral DLPFC by near-infrared spectroscopy (NIRS) during and immediately after rTMS. Obtained results demonstrated significant [oxy-Hb] decreases during rTMS, and significant differences in the time courses of [oxy-Hb] changes among three stimulus intensities, that is, [oxy-Hb] decreases were most prominent during the latter half of the stimulation and the first 30
s of poststimulation only at 15
mm condition (58% intensity). These results suggest that monitoring of brain functional changes due to rTMS using NIRS is useful for elucidating the brain mechanisms underlying the clinical effects of rTMS, and the effects of rTMS over contralateral DLPFC are obtained if the stimulus intensities are more than one-half of the motor thresholds.</description><subject>Adult</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Cerebrovascular Circulation - radiation effects</subject><subject>Depression</subject><subject>Depressive Disorder - physiopathology</subject><subject>Depressive Disorder - therapy</subject><subject>Energy Metabolism - physiology</subject><subject>Energy Metabolism - radiation effects</subject><subject>Evoked Potentials, Motor - physiology</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>Functional Laterality - radiation effects</subject><subject>Hemoglobin concentration</subject><subject>Humans</subject><subject>Magnetic stimulation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Near-infrared spectroscopy</subject><subject>Oxygen Consumption - physiology</subject><subject>Oxygen Consumption - radiation effects</subject><subject>Oxyhemoglobins - analysis</subject><subject>Oxyhemoglobins - metabolism</subject><subject>Prefrontal Cortex - blood supply</subject><subject>Prefrontal Cortex - physiology</subject><subject>Prefrontal Cortex - radiation effects</subject><subject>rTMS</subject><subject>Spectroscopy, Near-Infrared - methods</subject><subject>Therapy</subject><subject>Time Factors</subject><subject>Transcranial Magnetic Stimulation - methods</subject><issn>0168-0102</issn><issn>1872-8111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2KFDEUhYMoTjv6BiJZuas2SWWqUi6EYfAPRlxM70MquZlJk0rKJDVSz-OLmqIbxI2uLly-c5J7DkKvKdlTQrt3x32AJUHeM0JEXe0JaZ-gHRU9awSl9CnaVUw0hBJ2gV7kfCSVGHj7HF1QMQyMiX6Hft0VNy1-ydiFAiG7smIDMwQDQQOOFmtIMCbl8ehjNPgx-mUCrB9UuIdNhT3Ygm2KoVTIxxHwuNb5s7EJfizVZsXp8O0Ol4iTu3_4m32Pr3EAlRoXbFIJDM4z6JJi1nFecS6LWV-iZ1b5DK_O8xIdPn083Hxpbr9__npzfdtoznlpOkW07Umvh061rWVWcEoNCMOBkI6zXl9ZoStDjBasF5Zb0YtBq24YRc_bS_T2ZDunWP-di5xc1uC9ChCXLLuuv6IdHf4LMsJ4W7OvID-But6TE1g5JzeptEpK5FaiPMpTiXIrcdvWiqrszdl_GScwf0Tn1irw4QRATePRQZJZu60v41INT5ro_v3CbzU9s0Y</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Aoyama, Yoshiyuki</creator><creator>Hanaoka, Naoki</creator><creator>Kameyama, Masaki</creator><creator>Suda, Masashi</creator><creator>Sato, Toshimasa</creator><creator>Song, Mingqiao</creator><creator>Fukuda, Masato</creator><creator>Mikuni, Masahiko</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>2009</creationdate><title>Stimulus intensity dependence of cerebral blood volume changes in left frontal lobe by low-frequency rTMS to right frontal lobe: A near-infrared spectroscopy study</title><author>Aoyama, Yoshiyuki ; Hanaoka, Naoki ; Kameyama, Masaki ; Suda, Masashi ; Sato, Toshimasa ; Song, Mingqiao ; Fukuda, Masato ; Mikuni, Masahiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-6a0cf707c96a33f2f8411de8d4e006427c5f8c0cf0dc8278f4f8789ca69b8743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Cerebrovascular Circulation - radiation effects</topic><topic>Depression</topic><topic>Depressive Disorder - physiopathology</topic><topic>Depressive Disorder - therapy</topic><topic>Energy Metabolism - physiology</topic><topic>Energy Metabolism - radiation effects</topic><topic>Evoked Potentials, Motor - physiology</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>Functional Laterality - radiation effects</topic><topic>Hemoglobin concentration</topic><topic>Humans</topic><topic>Magnetic stimulation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Near-infrared spectroscopy</topic><topic>Oxygen Consumption - physiology</topic><topic>Oxygen Consumption - radiation effects</topic><topic>Oxyhemoglobins - analysis</topic><topic>Oxyhemoglobins - metabolism</topic><topic>Prefrontal Cortex - blood supply</topic><topic>Prefrontal Cortex - physiology</topic><topic>Prefrontal Cortex - radiation effects</topic><topic>rTMS</topic><topic>Spectroscopy, Near-Infrared - methods</topic><topic>Therapy</topic><topic>Time Factors</topic><topic>Transcranial Magnetic Stimulation - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aoyama, Yoshiyuki</creatorcontrib><creatorcontrib>Hanaoka, Naoki</creatorcontrib><creatorcontrib>Kameyama, Masaki</creatorcontrib><creatorcontrib>Suda, Masashi</creatorcontrib><creatorcontrib>Sato, Toshimasa</creatorcontrib><creatorcontrib>Song, Mingqiao</creatorcontrib><creatorcontrib>Fukuda, Masato</creatorcontrib><creatorcontrib>Mikuni, Masahiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aoyama, Yoshiyuki</au><au>Hanaoka, Naoki</au><au>Kameyama, Masaki</au><au>Suda, Masashi</au><au>Sato, Toshimasa</au><au>Song, Mingqiao</au><au>Fukuda, Masato</au><au>Mikuni, Masahiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stimulus intensity dependence of cerebral blood volume changes in left frontal lobe by low-frequency rTMS to right frontal lobe: A near-infrared spectroscopy study</atitle><jtitle>Neuroscience research</jtitle><addtitle>Neurosci Res</addtitle><date>2009</date><risdate>2009</risdate><volume>63</volume><issue>1</issue><spage>47</spage><epage>51</epage><pages>47-51</pages><issn>0168-0102</issn><eissn>1872-8111</eissn><abstract>Repetitive transcranial magnetic stimulation (rTMS) has recently been widely employed for the investigation of brain function and treatment of psychiatric and neurological disorders. Although high and low stimulation frequencies are assumed to activate and deactivate brain function, respectively, the optimal parameters of rTMS for treatment of depression have been determined only on the basis of their clinical efficacy. In this study, we administered a 60-s low-frequency rTMS of three grades low intensities over the right dorsolateral prefrontal cortex (DLPFC) in 10 healthy volunteers, and monitored functional changes of the contralateral DLPFC by near-infrared spectroscopy (NIRS) during and immediately after rTMS. Obtained results demonstrated significant [oxy-Hb] decreases during rTMS, and significant differences in the time courses of [oxy-Hb] changes among three stimulus intensities, that is, [oxy-Hb] decreases were most prominent during the latter half of the stimulation and the first 30
s of poststimulation only at 15
mm condition (58% intensity). These results suggest that monitoring of brain functional changes due to rTMS using NIRS is useful for elucidating the brain mechanisms underlying the clinical effects of rTMS, and the effects of rTMS over contralateral DLPFC are obtained if the stimulus intensities are more than one-half of the motor thresholds.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>18992287</pmid><doi>10.1016/j.neures.2008.10.003</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Cerebrovascular Circulation - physiology Cerebrovascular Circulation - radiation effects Depression Depressive Disorder - physiopathology Depressive Disorder - therapy Energy Metabolism - physiology Energy Metabolism - radiation effects Evoked Potentials, Motor - physiology Female Functional Laterality - physiology Functional Laterality - radiation effects Hemoglobin concentration Humans Magnetic stimulation Male Middle Aged Near-infrared spectroscopy Oxygen Consumption - physiology Oxygen Consumption - radiation effects Oxyhemoglobins - analysis Oxyhemoglobins - metabolism Prefrontal Cortex - blood supply Prefrontal Cortex - physiology Prefrontal Cortex - radiation effects rTMS Spectroscopy, Near-Infrared - methods Therapy Time Factors Transcranial Magnetic Stimulation - methods |
| title | Stimulus intensity dependence of cerebral blood volume changes in left frontal lobe by low-frequency rTMS to right frontal lobe: A near-infrared spectroscopy study |
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