Activation of sphingosine kinase by muscarinic receptors enhances NO-mediated and attenuates EDHF-mediated vasorelaxation

Local formation of the sphingomyelin metabolite sphingosine-1-phosphate (S1P) within the vascular wall has been shown to modulate vascular reactivity. In this study we investigated whether sphingosine kinase, the enzyme responsible for S1P synthesis, plays a role in muscarinic receptor-mediated NO p...

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Veröffentlicht in:	Basic research in cardiology 2009, Vol.104 (1), p.50-59
Hauptverfasser:	Mulders, Arthur C. M., Mathy, Marie-Jeanne, Meyer zu Heringdorf, Dagmar, ter Braak, Michael, Hajji, Najat, Olthof, Dominique C., Michel, Martin C., Alewijnse, Astrid E., Peters, Stephan L. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Factors - physiology Cardiology Cerebrovascular Circulation - physiology DNA Primers Endothelium, Vascular - cytology Endothelium, Vascular - physiology Enzyme Activation - physiology Genetic Markers Luminescent Proteins - genetics Medicine Medicine & Public Health Mice Nitric Oxide - physiology Original Contribution Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Polymerase Chain Reaction Protein Transport Receptors, Muscarinic - physiology Vasodilation - physiology
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