Differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of GLP-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (MEMRI)

We have used manganese-enhanced magnetic resonance imaging (MEMRI) to show distinct patterns of neuronal activation within the hypothalamus and brainstem of fasted mice in response to peripheral injection of the anorexigenic agents glucagon-like peptide-1 (GLP-1), oxyntomodulin (OXM) and lithium chl...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2009-02, Vol.44 (3), p.1022-1031
Hauptverfasser:	Parkinson, James R.C., Chaudhri, Owais B., Kuo, Yu-Ting, Field, Benjamin C.T., Herlihy, Amy H., Dhillo, Waljit S., Ghatei, Mohammad A., Bloom, Stephen R., Bell, Jimmy D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Appetite Appetite Stimulants - administration & dosage Biomedical research Brain Mapping - methods Brain Stem - drug effects Brain Stem - physiology Chlorides Contrast Media Glucagon-Like Peptide 1 - administration & dosage Glucagon-like peptide-1 Gut peptides Hypothalamus Hypothalamus - drug effects Hypothalamus - physiology Image Enhancement - methods Injections Lithium chloride Lithium Chloride - administration & dosage Magnetic Resonance Imaging - methods Male Manganese Manganese Compounds Mice Mice, Inbred C57BL Mn2 MRI Nerve Net - drug effects Nerve Net - physiology Neurons - physiology NMR Nuclear magnetic resonance Obesity Oxyntomodulin Oxyntomodulin - administration & dosage Peptides Proglucagon Rodents Signal transduction Studies
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