Effects of KR-33028, a novel Na+ /H+ exchanger-1 inhibitor, on glutamate-induced neuronal cell death and ischemia-induced cerebral infarct

Abstract We investigated the effects of a novel Na+ /H+ exchanger-1 (NHE-1) inhibitor KR-33028 on glutamate excitotoxicity in cultured neuron cells in vitro and cerebral infarct in vivo by comparing its potency with that of zoniporide, a well-known, highly potent NHE-1 inhibitor. KR-33028 inhibited...

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Veröffentlicht in:	Brain research 2009-01, Vol.1248, p.22-30
Hauptverfasser:	Lee, Bo Kyung, Lee, Dong Ha, Park, Sok, Park, Sung Lyea, Yoon, Jae-Seok, Lee, Min Goo, Lee, Sunkyung, Yi, Kyu Yang, Yoo, Sung Eun, Lee, Kyung Hee, Kim, You-Sun, Lee, Soo Hwan, Baik, Eun Joo, Moon, Chang-Hyun, Jung, Yi-Sook
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biological and medical sciences Brain Ischemia Caspase 3 - metabolism Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cerebral infarction Cerebral Infarction - drug therapy Cerebral Infarction - pathology Cerebral Infarction - physiopathology Enzyme Activation - drug effects Glutamate Glutamic Acid - pharmacology Guanidines - pharmacology In Situ Nick-End Labeling KR-33028 Medical sciences Mice Microscopy, Confocal Microscopy, Fluorescence Na +/H + exchanger Necrosis Neurology Neurons - chemistry Neurons - drug effects Neurons - physiology Neuroprotective Agents - pharmacology Pyrazoles - pharmacology Rats Rats, Sprague-Dawley Sodium-Hydrogen Exchangers - antagonists & inhibitors Thiophenes - pharmacology Vascular diseases and vascular malformations of the nervous system Zoniporide
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