Antiangiogenic Potency of Various Chemotherapeutic Drugs for Metronomic Chemotherapy

From previous preclinical findings continuous low dose (metronomic) chemotherapy is thought to inhibit tumor angiogenesis. This suggests that activated endothelial cells may be more sensitive to chemotherapeutic drugs than tumor cells. Therefore, we assessed the IC 50 for several relevant chemothera...

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Veröffentlicht in:	Anticancer research 2004-05, Vol.24 (3A), p.1759-1763
Hauptverfasser:	DREVS, Joachim, FAKLER, Julia, BISELE, Silke, MEDINGER, Michael, BING, Gerlinde, ESSER, Norbert, MARME, Dieter, UNGER, Clemens
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - pharmacology Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Biological and medical sciences Carcinoma, Renal Cell - blood supply Carcinoma, Renal Cell - drug therapy Cell Division - drug effects Cell Line, Tumor Dose-Response Relationship, Drug Doxorubicin - administration & dosage Doxorubicin - pharmacology Drug Administration Schedule Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Etoposide - administration & dosage Etoposide - pharmacology Female Fluorouracil - administration & dosage Fluorouracil - pharmacology Humans Idarubicin - administration & dosage Idarubicin - pharmacology Kidney Neoplasms - blood supply Kidney Neoplasms - drug therapy Medical sciences Mice Mice, Inbred C3H Neoplasms - blood supply Neoplasms - drug therapy Neovascularization, Pathologic - drug therapy Paclitaxel - administration & dosage Paclitaxel - pharmacology Tumors
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