Nuclear β-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages

The entry of β‐catenin into vegetal cell nuclei beginning at the 16‐cell stage is one of the earliest known molecular asymmetries seen along the animal–vegetal axis in the sea urchin embryo. Nuclear β‐catenin activates a vegetal signaling cascade that mediates micromere specification and specificati...

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Veröffentlicht in:	Genesis (New York, N.Y. : 2000) N.Y. : 2000), 2004-07, Vol.39 (3), p.194-205
Hauptverfasser:	Wikramanayake, Athula H., Peterson, Robert, Chen, Jing, Huang, Ling, Bince, Joanna M., McClay, David R., Klein, William H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin Blotting, Northern Cell Differentiation - physiology Cell Lineage - physiology Cell Nucleus - metabolism Cytoskeletal Proteins - metabolism differentiation DNA Primers embryo Endoderm - physiology endomesoderm Fluorescent Antibody Technique Gastrula - metabolism gastrulation Gene Expression Profiling Gene Expression Regulation, Developmental In Situ Hybridization Mesoderm - physiology Microinjections Oligonucleotides, Antisense Plasmids - genetics primary mesenchyme cells Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction sea urchin Sea Urchins - embryology Sea Urchins - metabolism Signal Transduction - physiology Strongylocentrotus purpuratus Trans-Activators - metabolism Wnt Proteins Wnt8 Zebrafish Proteins
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