Grading the severity of cervical neoplasia based on combined histopathology, cytopathology, and HPV genotype distribution among 1,700 women referred to colposcopy in Oklahoma
Diagnosis and treatment of cervical cancer precursors rely on colposcopic biopsy, which is sometimes hampered by incorrect biopsy placement and the unclear prognostic value of poorly reproducible diagnoses such as cervical intraepithelial neoplasia (CIN) Grade 1 and 2. Searching for discrete disease...
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| Veröffentlicht in: | International journal of cancer 2009-02, Vol.124 (4), p.964-969 |
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| creator | Wentzensen, Nicolas Schiffman, Mark Dunn, S. Terence Zuna, Rosemary E. Walker, Joan Allen, Richard A. Zhang, Roy Sherman, Mark E. Wacholder, Sholom Jeronimo, Jose Gold, Michael A. Wang, Sophia S. |
| description | Diagnosis and treatment of cervical cancer precursors rely on colposcopic biopsy, which is sometimes hampered by incorrect biopsy placement and the unclear prognostic value of poorly reproducible diagnoses such as cervical intraepithelial neoplasia (CIN) Grade 1 and 2. Searching for discrete disease categories that incorporate the value of cytology and that reflect the causal role of particular HPV types, we analyzed histology, cytology and HPV genotype distributions in the Study to Understand Cervical Cancer Endpoints and Early Determinants (SUCCEED). This cross‐sectional study comprises ∼1,700 women referred to colposcopy or treatment for the spectrum of cervical disease, including 439 women with |
| doi_str_mv | 10.1002/ijc.23969 |
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Terence ; Zuna, Rosemary E. ; Walker, Joan ; Allen, Richard A. ; Zhang, Roy ; Sherman, Mark E. ; Wacholder, Sholom ; Jeronimo, Jose ; Gold, Michael A. ; Wang, Sophia S.</creator><creatorcontrib>Wentzensen, Nicolas ; Schiffman, Mark ; Dunn, S. Terence ; Zuna, Rosemary E. ; Walker, Joan ; Allen, Richard A. ; Zhang, Roy ; Sherman, Mark E. ; Wacholder, Sholom ; Jeronimo, Jose ; Gold, Michael A. ; Wang, Sophia S.</creatorcontrib><description>Diagnosis and treatment of cervical cancer precursors rely on colposcopic biopsy, which is sometimes hampered by incorrect biopsy placement and the unclear prognostic value of poorly reproducible diagnoses such as cervical intraepithelial neoplasia (CIN) Grade 1 and 2. Searching for discrete disease categories that incorporate the value of cytology and that reflect the causal role of particular HPV types, we analyzed histology, cytology and HPV genotype distributions in the Study to Understand Cervical Cancer Endpoints and Early Determinants (SUCCEED). This cross‐sectional study comprises ∼1,700 women referred to colposcopy or treatment for the spectrum of cervical disease, including 439 women with <CIN1, 429 CIN1, 322 CIN2, 297 CIN3 and 107 with cancer. Using hierarchical clustering of histology‐cytology groups based on HPV genotype distributions, we could plainly distinguish in this referral population 5 increasingly severe diagnostic groups of HPV‐positive women: (i) HPV‐positive women with <CIN2 histology and normal cytology, (ii) HPV positive women with <CIN2 histology and ASC or LSIL cytology; (iii) CIN2, including histologic CIN2 and HSIL cytology with any histology <CIN2; (iv) CIN3; and (v) invasive cervical cancer. The grouping of women with HSIL cytology, but without histological abnormalities to women with CIN2 suggests that in these cases the worst lesion was missed during colposcopy‐biopsy. We are now using these sharpened diagnostic categories to search for novel biomarkers predicting the risk of progression and invasion. © 2008 Wiley‐Liss, Inc.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.23969</identifier><identifier>PMID: 19030188</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; biomarker ; Biomarkers, Tumor ; Biopsy ; cervical cancer ; Cervical Intraepithelial Neoplasia - diagnosis ; Cervical Intraepithelial Neoplasia - epidemiology ; Cervical Intraepithelial Neoplasia - genetics ; Cervical Intraepithelial Neoplasia - virology ; CIN ; Colposcopy - methods ; Disease Progression ; epidemiology ; Female ; Female genital diseases ; Genes, Viral ; Genotype ; Gynecology. Andrology. Obstetrics ; HPV ; Human papillomavirus ; Humans ; Medical sciences ; Middle Aged ; Models, Biological ; molecular ; Oklahoma ; Papillomaviridae - genetics ; Risk ; SUCCEED ; Tumors ; Uterine Cervical Neoplasms - diagnosis ; Uterine Cervical Neoplasms - epidemiology ; Uterine Cervical Neoplasms - genetics ; Uterine Cervical Neoplasms - virology</subject><ispartof>International journal of cancer, 2009-02, Vol.124 (4), p.964-969</ispartof><rights>Copyright © 2008 Wiley‐Liss, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4159-3197a5c461a2b8383948923f6e1dcc6b115f5532633487c10f399c689a5449da3</citedby><cites>FETCH-LOGICAL-c4159-3197a5c461a2b8383948923f6e1dcc6b115f5532633487c10f399c689a5449da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.23969$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.23969$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20986742$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19030188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wentzensen, Nicolas</creatorcontrib><creatorcontrib>Schiffman, Mark</creatorcontrib><creatorcontrib>Dunn, S. Terence</creatorcontrib><creatorcontrib>Zuna, Rosemary E.</creatorcontrib><creatorcontrib>Walker, Joan</creatorcontrib><creatorcontrib>Allen, Richard A.</creatorcontrib><creatorcontrib>Zhang, Roy</creatorcontrib><creatorcontrib>Sherman, Mark E.</creatorcontrib><creatorcontrib>Wacholder, Sholom</creatorcontrib><creatorcontrib>Jeronimo, Jose</creatorcontrib><creatorcontrib>Gold, Michael A.</creatorcontrib><creatorcontrib>Wang, Sophia S.</creatorcontrib><title>Grading the severity of cervical neoplasia based on combined histopathology, cytopathology, and HPV genotype distribution among 1,700 women referred to colposcopy in Oklahoma</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Diagnosis and treatment of cervical cancer precursors rely on colposcopic biopsy, which is sometimes hampered by incorrect biopsy placement and the unclear prognostic value of poorly reproducible diagnoses such as cervical intraepithelial neoplasia (CIN) Grade 1 and 2. Searching for discrete disease categories that incorporate the value of cytology and that reflect the causal role of particular HPV types, we analyzed histology, cytology and HPV genotype distributions in the Study to Understand Cervical Cancer Endpoints and Early Determinants (SUCCEED). This cross‐sectional study comprises ∼1,700 women referred to colposcopy or treatment for the spectrum of cervical disease, including 439 women with <CIN1, 429 CIN1, 322 CIN2, 297 CIN3 and 107 with cancer. Using hierarchical clustering of histology‐cytology groups based on HPV genotype distributions, we could plainly distinguish in this referral population 5 increasingly severe diagnostic groups of HPV‐positive women: (i) HPV‐positive women with <CIN2 histology and normal cytology, (ii) HPV positive women with <CIN2 histology and ASC or LSIL cytology; (iii) CIN2, including histologic CIN2 and HSIL cytology with any histology <CIN2; (iv) CIN3; and (v) invasive cervical cancer. The grouping of women with HSIL cytology, but without histological abnormalities to women with CIN2 suggests that in these cases the worst lesion was missed during colposcopy‐biopsy. We are now using these sharpened diagnostic categories to search for novel biomarkers predicting the risk of progression and invasion. © 2008 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>biomarker</subject><subject>Biomarkers, Tumor</subject><subject>Biopsy</subject><subject>cervical cancer</subject><subject>Cervical Intraepithelial Neoplasia - diagnosis</subject><subject>Cervical Intraepithelial Neoplasia - epidemiology</subject><subject>Cervical Intraepithelial Neoplasia - genetics</subject><subject>Cervical Intraepithelial Neoplasia - virology</subject><subject>CIN</subject><subject>Colposcopy - methods</subject><subject>Disease Progression</subject><subject>epidemiology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Genes, Viral</subject><subject>Genotype</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>HPV</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>molecular</subject><subject>Oklahoma</subject><subject>Papillomaviridae - genetics</subject><subject>Risk</subject><subject>SUCCEED</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><subject>Uterine Cervical Neoplasms - epidemiology</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Uterine Cervical Neoplasms - virology</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAYRS0EokNhwQsgb0Cq1LT-i2Mv0Yj-oEplAWyjL44z4-LYwc60ykvxjLjMCMQCsbItH91rfweh15ScUULYubszZ4xrqZ-gFSW6qQij9VO0KnekaiiXR-hFzneEUFoT8RwdUU04oUqt0I_LBL0LGzxvLc723iY3LzgO2Nh07wx4HGycPGQHuINsexwDNnHsXCj7rctznGDeRh83yyk2y19HCD2--vQVb2yI8zJZ3Bc-uW43u5ICYyy99LQhBD_E0Qac7GBTKrlzLB1-itnEacEu4NtvHrZxhJfo2QA-21eH9Rh9ufjweX1V3dxeXq_f31RG0FpXnOoGaiMkBdYprrgWSjM-SEt7Y2RX5jDUNWeSc6EaQ8nAtTZSaaiF0D3wY_Runzul-H1n89yOLhvrPZRx7HIrZSOk1Oq_ICOSScEewZM9aFLMufy0nZIbIS0tJe2jxbZYbH9ZLOybQ-iuG23_hzxoK8DbAwC5OBoSBOPyb44RrcoDWeHO99yD83b5d2N7_XG9r_4Jis-1DQ</recordid><startdate>20090215</startdate><enddate>20090215</enddate><creator>Wentzensen, Nicolas</creator><creator>Schiffman, Mark</creator><creator>Dunn, S. Terence</creator><creator>Zuna, Rosemary E.</creator><creator>Walker, Joan</creator><creator>Allen, Richard A.</creator><creator>Zhang, Roy</creator><creator>Sherman, Mark E.</creator><creator>Wacholder, Sholom</creator><creator>Jeronimo, Jose</creator><creator>Gold, Michael A.</creator><creator>Wang, Sophia S.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20090215</creationdate><title>Grading the severity of cervical neoplasia based on combined histopathology, cytopathology, and HPV genotype distribution among 1,700 women referred to colposcopy in Oklahoma</title><author>Wentzensen, Nicolas ; Schiffman, Mark ; Dunn, S. Terence ; Zuna, Rosemary E. ; Walker, Joan ; Allen, Richard A. ; Zhang, Roy ; Sherman, Mark E. ; Wacholder, Sholom ; Jeronimo, Jose ; Gold, Michael A. ; Wang, Sophia S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4159-3197a5c461a2b8383948923f6e1dcc6b115f5532633487c10f399c689a5449da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>biomarker</topic><topic>Biomarkers, Tumor</topic><topic>Biopsy</topic><topic>cervical cancer</topic><topic>Cervical Intraepithelial Neoplasia - diagnosis</topic><topic>Cervical Intraepithelial Neoplasia - epidemiology</topic><topic>Cervical Intraepithelial Neoplasia - genetics</topic><topic>Cervical Intraepithelial Neoplasia - virology</topic><topic>CIN</topic><topic>Colposcopy - methods</topic><topic>Disease Progression</topic><topic>epidemiology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Genes, Viral</topic><topic>Genotype</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>HPV</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>molecular</topic><topic>Oklahoma</topic><topic>Papillomaviridae - genetics</topic><topic>Risk</topic><topic>SUCCEED</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - diagnosis</topic><topic>Uterine Cervical Neoplasms - epidemiology</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Uterine Cervical Neoplasms - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wentzensen, Nicolas</creatorcontrib><creatorcontrib>Schiffman, Mark</creatorcontrib><creatorcontrib>Dunn, S. 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Terence</au><au>Zuna, Rosemary E.</au><au>Walker, Joan</au><au>Allen, Richard A.</au><au>Zhang, Roy</au><au>Sherman, Mark E.</au><au>Wacholder, Sholom</au><au>Jeronimo, Jose</au><au>Gold, Michael A.</au><au>Wang, Sophia S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Grading the severity of cervical neoplasia based on combined histopathology, cytopathology, and HPV genotype distribution among 1,700 women referred to colposcopy in Oklahoma</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2009-02-15</date><risdate>2009</risdate><volume>124</volume><issue>4</issue><spage>964</spage><epage>969</epage><pages>964-969</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>Diagnosis and treatment of cervical cancer precursors rely on colposcopic biopsy, which is sometimes hampered by incorrect biopsy placement and the unclear prognostic value of poorly reproducible diagnoses such as cervical intraepithelial neoplasia (CIN) Grade 1 and 2. Searching for discrete disease categories that incorporate the value of cytology and that reflect the causal role of particular HPV types, we analyzed histology, cytology and HPV genotype distributions in the Study to Understand Cervical Cancer Endpoints and Early Determinants (SUCCEED). This cross‐sectional study comprises ∼1,700 women referred to colposcopy or treatment for the spectrum of cervical disease, including 439 women with <CIN1, 429 CIN1, 322 CIN2, 297 CIN3 and 107 with cancer. Using hierarchical clustering of histology‐cytology groups based on HPV genotype distributions, we could plainly distinguish in this referral population 5 increasingly severe diagnostic groups of HPV‐positive women: (i) HPV‐positive women with <CIN2 histology and normal cytology, (ii) HPV positive women with <CIN2 histology and ASC or LSIL cytology; (iii) CIN2, including histologic CIN2 and HSIL cytology with any histology <CIN2; (iv) CIN3; and (v) invasive cervical cancer. The grouping of women with HSIL cytology, but without histological abnormalities to women with CIN2 suggests that in these cases the worst lesion was missed during colposcopy‐biopsy. We are now using these sharpened diagnostic categories to search for novel biomarkers predicting the risk of progression and invasion. © 2008 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19030188</pmid><doi>10.1002/ijc.23969</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences biomarker Biomarkers, Tumor Biopsy cervical cancer Cervical Intraepithelial Neoplasia - diagnosis Cervical Intraepithelial Neoplasia - epidemiology Cervical Intraepithelial Neoplasia - genetics Cervical Intraepithelial Neoplasia - virology CIN Colposcopy - methods Disease Progression epidemiology Female Female genital diseases Genes, Viral Genotype Gynecology. Andrology. Obstetrics HPV Human papillomavirus Humans Medical sciences Middle Aged Models, Biological molecular Oklahoma Papillomaviridae - genetics Risk SUCCEED Tumors Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - epidemiology Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - virology |
| title | Grading the severity of cervical neoplasia based on combined histopathology, cytopathology, and HPV genotype distribution among 1,700 women referred to colposcopy in Oklahoma |
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