Longitudinal comparison study of pressure relief (C-Flex™) vs. CPAP in OSA patients
Background Continuous positive airway pressure (CPAP) devices with the option of flexible pressure delivery (e.g., C-Flex) are thought to provide an improved degree of comfort and result in better therapeutic adherence while maintaining standard CPAP efficacy. The purpose of this study was to compar...
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creator | Dolan, Diana C. Okonkwo, Renata Gfullner, Florian Hansbrough, J. Randall Strobel, Richard J. Rosenthal, Leon |
description | Background
Continuous positive airway pressure (CPAP) devices with the option of flexible pressure delivery (e.g., C-Flex) are thought to provide an improved degree of comfort and result in better therapeutic adherence while maintaining standard CPAP efficacy. The purpose of this study was to compare adherence and subjective measures of comfort between C-Flex and CPAP treatment.
Methods
The study was an international, multisite, single-blinded study with participants randomized to either C-Flex or CPAP. Participants completed subjective measures of sleepiness and comfort at baseline, and at 30-, 90-, and 180-day follow-ups. Additionally, compliance data were downloaded from the device at each follow-up. Repeated measures analysis of variance was used to assess the effects of treatment.
Results
There were 138 men and 46 women (average age of 48 ± 9.2, average Epworth Sleepiness Scale score of 14.9 ± 3.6, and average diagnostic apnea/hypopnea index (AHI) of 51.9 ± 27.7). C-Flex and CPAP groups were comparable on baseline measures, achieved comparable AHI on titration, and had comparable PAP pressure requirements. C-Flex users had comparable average hours of use per night and total nights of use across the study, but had a trend (
p
< .07) toward achieving greater total hours of utilization. While both groups had comparable decreases in sleepiness, C-Flex users reported on visual analog scales greater comfort (64.3 vs. 57.4;
p
= .01).
Conclusions
The results of this study demonstrated that C-Flex has comparable resolution of respiratory indices and adherence. Furthermore, C-Flex users reported greater mask comfort. |
doi_str_mv | 10.1007/s11325-008-0199-1 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66746646</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2241172501</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-2f1e6e9fe7bf71f2188ef8de34ddc9eb09a44928157c2654ffb3e2fdfdbe06393</originalsourceid><addsrcrecordid>eNp1kMFu1DAQhi0EoqXwAFyQhQSiBxePEzv2cbWitNJKrQQ9W04yrlxlk-BJEL3zJDwaT0KWXbUSEieP7O-f8XyMvQZ5BlJWHwmgUFpIaYUE5wQ8YceglRJQSff0by2F06CO2AuiOymhtA6esyOwWi_R6pjdbIb-Nk1zm_rQ8WbYjiEnGnpOy909HyIfMxLNGXnGLmHkH9bivMMfv3_-OuXf6Yyvr1fXPPX86suKj2FK2E_0kj2LoSN8dThP2M35p6_rC7G5-ny5Xm1EUxo9CRUBDbqIVR0riAqsxWhbLMq2bRzW0oWydMqCrhpldBljXaCKbWxrlKZwxQl7v-875uHbjDT5baIGuy70OMzkjalKY0qzgG__Ae-GOS8rk7elrIy2egfBHmryQJQx-jGnbcj3HqTfCfd74X4R7nfCPSyZN4fGc73F9jFxMLwA7w5AoCZ0MYe-SfTAKelcIQu7cGrP0fLU32J-_OH_p_8BqK2YAg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>840765856</pqid></control><display><type>article</type><title>Longitudinal comparison study of pressure relief (C-Flex™) vs. CPAP in OSA patients</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Dolan, Diana C. ; Okonkwo, Renata ; Gfullner, Florian ; Hansbrough, J. Randall ; Strobel, Richard J. ; Rosenthal, Leon</creator><creatorcontrib>Dolan, Diana C. ; Okonkwo, Renata ; Gfullner, Florian ; Hansbrough, J. Randall ; Strobel, Richard J. ; Rosenthal, Leon</creatorcontrib><description>Background
Continuous positive airway pressure (CPAP) devices with the option of flexible pressure delivery (e.g., C-Flex) are thought to provide an improved degree of comfort and result in better therapeutic adherence while maintaining standard CPAP efficacy. The purpose of this study was to compare adherence and subjective measures of comfort between C-Flex and CPAP treatment.
Methods
The study was an international, multisite, single-blinded study with participants randomized to either C-Flex or CPAP. Participants completed subjective measures of sleepiness and comfort at baseline, and at 30-, 90-, and 180-day follow-ups. Additionally, compliance data were downloaded from the device at each follow-up. Repeated measures analysis of variance was used to assess the effects of treatment.
Results
There were 138 men and 46 women (average age of 48 ± 9.2, average Epworth Sleepiness Scale score of 14.9 ± 3.6, and average diagnostic apnea/hypopnea index (AHI) of 51.9 ± 27.7). C-Flex and CPAP groups were comparable on baseline measures, achieved comparable AHI on titration, and had comparable PAP pressure requirements. C-Flex users had comparable average hours of use per night and total nights of use across the study, but had a trend (
p
< .07) toward achieving greater total hours of utilization. While both groups had comparable decreases in sleepiness, C-Flex users reported on visual analog scales greater comfort (64.3 vs. 57.4;
p
= .01).
Conclusions
The results of this study demonstrated that C-Flex has comparable resolution of respiratory indices and adherence. Furthermore, C-Flex users reported greater mask comfort.</description><identifier>ISSN: 1520-9512</identifier><identifier>EISSN: 1522-1709</identifier><identifier>DOI: 10.1007/s11325-008-0199-1</identifier><identifier>PMID: 18551327</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Continuous positive airway pressure ; Continuous Positive Airway Pressure - methods ; Dentistry ; Disorders of Excessive Somnolence - diagnosis ; Disorders of Excessive Somnolence - etiology ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Humans ; Hypoventilation ; Internal Medicine ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Nervous system (semeiology, syndromes) ; Neurology ; Original Article ; Otorhinolaryngology ; Patient Compliance ; Pediatrics ; Pneumology/Respiratory System ; Polysomnography ; Pressure ; Prospective Studies ; Single-Blind Method ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - diagnosis ; Sleep Apnea, Obstructive - therapy ; Sleep. Vigilance ; Surveys and Questionnaires ; Vertebrates: nervous system and sense organs</subject><ispartof>Sleep & breathing, 2009-02, Vol.13 (1), p.73-77</ispartof><rights>Springer-Verlag 2008</rights><rights>2009 INIST-CNRS</rights><rights>Springer-Verlag 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-2f1e6e9fe7bf71f2188ef8de34ddc9eb09a44928157c2654ffb3e2fdfdbe06393</citedby><cites>FETCH-LOGICAL-c465t-2f1e6e9fe7bf71f2188ef8de34ddc9eb09a44928157c2654ffb3e2fdfdbe06393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11325-008-0199-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11325-008-0199-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20993038$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18551327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dolan, Diana C.</creatorcontrib><creatorcontrib>Okonkwo, Renata</creatorcontrib><creatorcontrib>Gfullner, Florian</creatorcontrib><creatorcontrib>Hansbrough, J. Randall</creatorcontrib><creatorcontrib>Strobel, Richard J.</creatorcontrib><creatorcontrib>Rosenthal, Leon</creatorcontrib><title>Longitudinal comparison study of pressure relief (C-Flex™) vs. CPAP in OSA patients</title><title>Sleep & breathing</title><addtitle>Sleep Breath</addtitle><addtitle>Sleep Breath</addtitle><description>Background
Continuous positive airway pressure (CPAP) devices with the option of flexible pressure delivery (e.g., C-Flex) are thought to provide an improved degree of comfort and result in better therapeutic adherence while maintaining standard CPAP efficacy. The purpose of this study was to compare adherence and subjective measures of comfort between C-Flex and CPAP treatment.
Methods
The study was an international, multisite, single-blinded study with participants randomized to either C-Flex or CPAP. Participants completed subjective measures of sleepiness and comfort at baseline, and at 30-, 90-, and 180-day follow-ups. Additionally, compliance data were downloaded from the device at each follow-up. Repeated measures analysis of variance was used to assess the effects of treatment.
Results
There were 138 men and 46 women (average age of 48 ± 9.2, average Epworth Sleepiness Scale score of 14.9 ± 3.6, and average diagnostic apnea/hypopnea index (AHI) of 51.9 ± 27.7). C-Flex and CPAP groups were comparable on baseline measures, achieved comparable AHI on titration, and had comparable PAP pressure requirements. C-Flex users had comparable average hours of use per night and total nights of use across the study, but had a trend (
p
< .07) toward achieving greater total hours of utilization. While both groups had comparable decreases in sleepiness, C-Flex users reported on visual analog scales greater comfort (64.3 vs. 57.4;
p
= .01).
Conclusions
The results of this study demonstrated that C-Flex has comparable resolution of respiratory indices and adherence. Furthermore, C-Flex users reported greater mask comfort.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Continuous positive airway pressure</subject><subject>Continuous Positive Airway Pressure - methods</subject><subject>Dentistry</subject><subject>Disorders of Excessive Somnolence - diagnosis</subject><subject>Disorders of Excessive Somnolence - etiology</subject><subject>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hypoventilation</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Original Article</subject><subject>Otorhinolaryngology</subject><subject>Patient Compliance</subject><subject>Pediatrics</subject><subject>Pneumology/Respiratory System</subject><subject>Polysomnography</subject><subject>Pressure</subject><subject>Prospective Studies</subject><subject>Single-Blind Method</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - diagnosis</subject><subject>Sleep Apnea, Obstructive - therapy</subject><subject>Sleep. Vigilance</subject><subject>Surveys and Questionnaires</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>1520-9512</issn><issn>1522-1709</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kMFu1DAQhi0EoqXwAFyQhQSiBxePEzv2cbWitNJKrQQ9W04yrlxlk-BJEL3zJDwaT0KWXbUSEieP7O-f8XyMvQZ5BlJWHwmgUFpIaYUE5wQ8YceglRJQSff0by2F06CO2AuiOymhtA6esyOwWi_R6pjdbIb-Nk1zm_rQ8WbYjiEnGnpOy909HyIfMxLNGXnGLmHkH9bivMMfv3_-OuXf6Yyvr1fXPPX86suKj2FK2E_0kj2LoSN8dThP2M35p6_rC7G5-ny5Xm1EUxo9CRUBDbqIVR0riAqsxWhbLMq2bRzW0oWydMqCrhpldBljXaCKbWxrlKZwxQl7v-875uHbjDT5baIGuy70OMzkjalKY0qzgG__Ae-GOS8rk7elrIy2egfBHmryQJQx-jGnbcj3HqTfCfd74X4R7nfCPSyZN4fGc73F9jFxMLwA7w5AoCZ0MYe-SfTAKelcIQu7cGrP0fLU32J-_OH_p_8BqK2YAg</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Dolan, Diana C.</creator><creator>Okonkwo, Renata</creator><creator>Gfullner, Florian</creator><creator>Hansbrough, J. Randall</creator><creator>Strobel, Richard J.</creator><creator>Rosenthal, Leon</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2R</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>Longitudinal comparison study of pressure relief (C-Flex™) vs. CPAP in OSA patients</title><author>Dolan, Diana C. ; Okonkwo, Renata ; Gfullner, Florian ; Hansbrough, J. Randall ; Strobel, Richard J. ; Rosenthal, Leon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-2f1e6e9fe7bf71f2188ef8de34ddc9eb09a44928157c2654ffb3e2fdfdbe06393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Continuous positive airway pressure</topic><topic>Continuous Positive Airway Pressure - methods</topic><topic>Dentistry</topic><topic>Disorders of Excessive Somnolence - diagnosis</topic><topic>Disorders of Excessive Somnolence - etiology</topic><topic>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hypoventilation</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Original Article</topic><topic>Otorhinolaryngology</topic><topic>Patient Compliance</topic><topic>Pediatrics</topic><topic>Pneumology/Respiratory System</topic><topic>Polysomnography</topic><topic>Pressure</topic><topic>Prospective Studies</topic><topic>Single-Blind Method</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - diagnosis</topic><topic>Sleep Apnea, Obstructive - therapy</topic><topic>Sleep. Vigilance</topic><topic>Surveys and Questionnaires</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dolan, Diana C.</creatorcontrib><creatorcontrib>Okonkwo, Renata</creatorcontrib><creatorcontrib>Gfullner, Florian</creatorcontrib><creatorcontrib>Hansbrough, J. Randall</creatorcontrib><creatorcontrib>Strobel, Richard J.</creatorcontrib><creatorcontrib>Rosenthal, Leon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Social Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Sleep & breathing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dolan, Diana C.</au><au>Okonkwo, Renata</au><au>Gfullner, Florian</au><au>Hansbrough, J. Randall</au><au>Strobel, Richard J.</au><au>Rosenthal, Leon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal comparison study of pressure relief (C-Flex™) vs. CPAP in OSA patients</atitle><jtitle>Sleep & breathing</jtitle><stitle>Sleep Breath</stitle><addtitle>Sleep Breath</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>13</volume><issue>1</issue><spage>73</spage><epage>77</epage><pages>73-77</pages><issn>1520-9512</issn><eissn>1522-1709</eissn><abstract>Background
Continuous positive airway pressure (CPAP) devices with the option of flexible pressure delivery (e.g., C-Flex) are thought to provide an improved degree of comfort and result in better therapeutic adherence while maintaining standard CPAP efficacy. The purpose of this study was to compare adherence and subjective measures of comfort between C-Flex and CPAP treatment.
Methods
The study was an international, multisite, single-blinded study with participants randomized to either C-Flex or CPAP. Participants completed subjective measures of sleepiness and comfort at baseline, and at 30-, 90-, and 180-day follow-ups. Additionally, compliance data were downloaded from the device at each follow-up. Repeated measures analysis of variance was used to assess the effects of treatment.
Results
There were 138 men and 46 women (average age of 48 ± 9.2, average Epworth Sleepiness Scale score of 14.9 ± 3.6, and average diagnostic apnea/hypopnea index (AHI) of 51.9 ± 27.7). C-Flex and CPAP groups were comparable on baseline measures, achieved comparable AHI on titration, and had comparable PAP pressure requirements. C-Flex users had comparable average hours of use per night and total nights of use across the study, but had a trend (
p
< .07) toward achieving greater total hours of utilization. While both groups had comparable decreases in sleepiness, C-Flex users reported on visual analog scales greater comfort (64.3 vs. 57.4;
p
= .01).
Conclusions
The results of this study demonstrated that C-Flex has comparable resolution of respiratory indices and adherence. Furthermore, C-Flex users reported greater mask comfort.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18551327</pmid><doi>10.1007/s11325-008-0199-1</doi><tpages>5</tpages></addata></record> |
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subjects | Adult Aged Biological and medical sciences Continuous positive airway pressure Continuous Positive Airway Pressure - methods Dentistry Disorders of Excessive Somnolence - diagnosis Disorders of Excessive Somnolence - etiology Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Humans Hypoventilation Internal Medicine Male Medical sciences Medicine Medicine & Public Health Middle Aged Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Nervous system (semeiology, syndromes) Neurology Original Article Otorhinolaryngology Patient Compliance Pediatrics Pneumology/Respiratory System Polysomnography Pressure Prospective Studies Single-Blind Method Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - diagnosis Sleep Apnea, Obstructive - therapy Sleep. Vigilance Surveys and Questionnaires Vertebrates: nervous system and sense organs |
title | Longitudinal comparison study of pressure relief (C-Flex™) vs. CPAP in OSA patients |
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