NMDA-mediated modulation of dopamine release is modified in rat prefrontal cortex and nucleus accumbens after chronic nicotine treatment

In this study, we investigate the effects of chronic administration of (-)nicotine on the function of the NMDA-mediated modulation of [³H]dopamine (DA) release in rat prefrontal cortex (PFC) and nucleus accumbens (NAc). In the PFC synaptosomes NMDA in a concentration-dependent manner evoked [³H]DA r...

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Veröffentlicht in:	Journal of neurochemistry 2009-01, Vol.108 (2), p.408-416
Hauptverfasser:	Grilli, Massimo, Pittaluga, Anna, Merlo-Pich, Emilio, Marchi, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	[3H]dopamine release [³H]dopamine release Analysis of Variance Animals Biochemistry Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors chronic (-)nicotine treatment chronic (−)nicotine treatment Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dizocilpine Maleate - pharmacology Dopamine - metabolism Dose-Response Relationship, Drug Drug Administration Schedule Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology Glycine - pharmacology isolated nerve endings Male Medical sciences N-Methylaspartate - pharmacology Neurology Neurotransmitters Nicotine Nicotine - administration & dosage Nicotinic Agonists - administration & dosage nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - ultrastructure Pipecolic Acids - pharmacology Potassium - pharmacology pre-synaptic NMDA receptors prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - ultrastructure Rats Rats, Sprague-Dawley Rodents Synaptosomes - drug effects Time Factors Tritium - metabolism Vertebrates: nervous system and sense organs
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