Nocistatin and nociceptin exert opposite effects on the excitability of central amygdala nucleus-periaqueductal gray projection neurons

Central amygdala nucleus (CeA)-periaqueductal gray (PAG) pathway is the component of descending antinociceptive circuitry. Nociceptin/orphanin FQ (N/OFQ) and nocistatin (NST) produce supraspinal pronociceptive and antinociceptive effects, respectively. We hypothesized that opposite effects of N/OFQ...

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Veröffentlicht in:	Molecular and cellular neuroscience 2009-01, Vol.40 (1), p.76-88
Hauptverfasser:	Chen, Ying-Ling, Li, Allen H., Yeh, Tu-Hsueh, Chou, An-Hsun, Wang, Hung-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala - anatomy & histology Amygdala - metabolism Animals CeA-PAG projection neurons Central amygdala nucleus Efferent Pathways - anatomy & histology Efferent Pathways - physiology Membrane Potentials - physiology Neurons - cytology Neurons - physiology Nociceptin Nociceptin/orphanin FQ Nocistatin Opioid Peptides - metabolism Pain - metabolism Patch-Clamp Techniques Periaqueductal gray Periaqueductal Gray - anatomy & histology Periaqueductal Gray - metabolism Potassium Channels, Inwardly Rectifying - metabolism Rats Rats, Sprague-Dawley
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