Effectiveness of Atrial Fibrillation as an Independent Predictor of Death and Coronary Events in Patients Having Coronary Angiography
The impact of atrial fibrillation (AF) on future coronary events is uncertain. In particular, the prognostic impact of AF in the clinically important population of coronary patients who undergo angiography is unknown. The aim of this study was to investigate (1) the prevalence of AF, (2) its associa...
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| Veröffentlicht in: | The American journal of cardiology 2009, Vol.103 (1), p.36-40 |
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| creator | Marte, Thomas, MD Saely, Christoph H., MD Schmid, Fabian, MD Koch, Lorena, MD Drexel, Heinz, MD |
| description | The impact of atrial fibrillation (AF) on future coronary events is uncertain. In particular, the prognostic impact of AF in the clinically important population of coronary patients who undergo angiography is unknown. The aim of this study was to investigate (1) the prevalence of AF, (2) its association with coronary atherosclerosis, and (3) its impact on future coronary events in patients who undergo angiography. Electrocardiograms were evaluated in a consecutive series of 613 patients who underwent coronary angiography. Prospectively, death and cardiovascular events were recorded over 4.0 ± 0.6 years. Among these patients, 37 (6%) at baseline had AF, and 576 (94%) were in sinus rhythm. The presence of AF was associated with a lower prevalence of coronary artery disease and of coronary diameter narrowing ≥50% on baseline angiography. However, prospectively, patients with AF were at a strongly increased risk for all-cause mortality (adjusted hazard ratio 5.15, 95% confidence interval 2.36 to 11.26, p |
| doi_str_mv | 10.1016/j.amjcard.2008.08.028 |
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In particular, the prognostic impact of AF in the clinically important population of coronary patients who undergo angiography is unknown. The aim of this study was to investigate (1) the prevalence of AF, (2) its association with coronary atherosclerosis, and (3) its impact on future coronary events in patients who undergo angiography. Electrocardiograms were evaluated in a consecutive series of 613 patients who underwent coronary angiography. Prospectively, death and cardiovascular events were recorded over 4.0 ± 0.6 years. Among these patients, 37 (6%) at baseline had AF, and 576 (94%) were in sinus rhythm. The presence of AF was associated with a lower prevalence of coronary artery disease and of coronary diameter narrowing ≥50% on baseline angiography. However, prospectively, patients with AF were at a strongly increased risk for all-cause mortality (adjusted hazard ratio 5.15, 95% confidence interval 2.36 to 11.26, p <0.001), coronary death (hazard ratio 8.16, 95% confidence interval 2.89 to 23.09, p <0.001), and major coronary events (hazard ratio 3.80, 95% confidence interval 1.45 to 9.94, p = 0.007). In conclusion, although inversely associated with the presence of angiographically determined coronary atherosclerosis, AF is a strong predictor of death and future coronary events in patients with coronary artery disease who undergo coronary angiography.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2008.08.028</identifier><identifier>PMID: 19101226</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Atrial Fibrillation - complications ; Atrial Fibrillation - mortality ; Atrial Fibrillation - physiopathology ; Austria - epidemiology ; Biological and medical sciences ; Cardiac arrhythmia ; Cardiac dysrhythmias ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Cardiovascular system ; Coronary Angiography ; Coronary Disease - complications ; Coronary Disease - diagnostic imaging ; Coronary Disease - physiopathology ; Coronary heart disease ; Death, Sudden, Cardiac - epidemiology ; Death, Sudden, Cardiac - etiology ; Deaths ; Effectiveness studies ; Electrocardiography ; Female ; Follow-Up Studies ; Heart ; Humans ; Incidence ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical prognosis ; Medical sciences ; Middle Aged ; Prognosis ; Prospective Studies ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Risk Assessment ; Risk Factors ; Survival Rate - trends ; Time Factors ; Ultrasonic imaging</subject><ispartof>The American journal of cardiology, 2009, Vol.103 (1), p.36-40</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><rights>2009 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Jan 1, 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-7bbbd6b47bd6a23ffe07497991d161c5dc3224dd65dd66cc66b5e67263ea08413</citedby><cites>FETCH-LOGICAL-c541t-7bbbd6b47bd6a23ffe07497991d161c5dc3224dd65dd66cc66b5e67263ea08413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.amjcard.2008.08.028$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21003229$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19101226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marte, Thomas, MD</creatorcontrib><creatorcontrib>Saely, Christoph H., MD</creatorcontrib><creatorcontrib>Schmid, Fabian, MD</creatorcontrib><creatorcontrib>Koch, Lorena, MD</creatorcontrib><creatorcontrib>Drexel, Heinz, MD</creatorcontrib><title>Effectiveness of Atrial Fibrillation as an Independent Predictor of Death and Coronary Events in Patients Having Coronary Angiography</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>The impact of atrial fibrillation (AF) on future coronary events is uncertain. In particular, the prognostic impact of AF in the clinically important population of coronary patients who undergo angiography is unknown. The aim of this study was to investigate (1) the prevalence of AF, (2) its association with coronary atherosclerosis, and (3) its impact on future coronary events in patients who undergo angiography. Electrocardiograms were evaluated in a consecutive series of 613 patients who underwent coronary angiography. Prospectively, death and cardiovascular events were recorded over 4.0 ± 0.6 years. Among these patients, 37 (6%) at baseline had AF, and 576 (94%) were in sinus rhythm. The presence of AF was associated with a lower prevalence of coronary artery disease and of coronary diameter narrowing ≥50% on baseline angiography. However, prospectively, patients with AF were at a strongly increased risk for all-cause mortality (adjusted hazard ratio 5.15, 95% confidence interval 2.36 to 11.26, p <0.001), coronary death (hazard ratio 8.16, 95% confidence interval 2.89 to 23.09, p <0.001), and major coronary events (hazard ratio 3.80, 95% confidence interval 1.45 to 9.94, p = 0.007). In conclusion, although inversely associated with the presence of angiographically determined coronary atherosclerosis, AF is a strong predictor of death and future coronary events in patients with coronary artery disease who undergo coronary angiography.</description><subject>Aged</subject><subject>Atrial Fibrillation - complications</subject><subject>Atrial Fibrillation - mortality</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Austria - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular system</subject><subject>Coronary Angiography</subject><subject>Coronary Disease - complications</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - physiopathology</subject><subject>Coronary heart disease</subject><subject>Death, Sudden, Cardiac - epidemiology</subject><subject>Death, Sudden, Cardiac - etiology</subject><subject>Deaths</subject><subject>Effectiveness studies</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Humans</subject><subject>Incidence</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Survival Rate - trends</subject><subject>Time Factors</subject><subject>Ultrasonic imaging</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl1r2zAUhsXYWNNuP2FDDNo7Z_qwZftmJWTpWiis0O5ayJKcynOkVHIC-QH73zteTAu9GegTPefVOXqF0CdK5pRQ8bWbq02nVTRzRkg1Hxur3qAZrco6ozXlb9GMEMKymub1CTpNqYMtpYV4j07gnFDGxAz9WbWt1YPbW29TwqHFiyE61eMr10TX92pwwWOVsPL4xhu7tTD4Ad9Fa5weQhxDvls1PAJh8DLE4FU84BUIDgk7j-9A4t_6Wu2dX78gC792YR3V9vHwAb1rVZ_sx2k-Q7-uVg_L6-z254-b5eI200VOh6xsmsaIJi9hVIxD5qTM67KuqaGC6sJozlhujCigC62FaAorSia4VaTKKT9DF0fdbQxPO5sGuXFJWyjT27BLUogy50XFAfzyCuzCLnrITTJOeAX3jmrFEdIxpBRtK7fRbaA0SYkcTZKdnEySo0lybKyCuM-T-K7ZWPMSNbkCwPkEqKRV30bltUvPHKOEQKE1cJdHzsKb7Z2NMml4aw3WRDBVmuD-m8q3Vwq6d97Bpb_twabnoqlMTBJ5P_6o8UORitA8JzX_C_EyyCQ</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Marte, Thomas, MD</creator><creator>Saely, Christoph H., MD</creator><creator>Schmid, Fabian, MD</creator><creator>Koch, Lorena, MD</creator><creator>Drexel, Heinz, MD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2009</creationdate><title>Effectiveness of Atrial Fibrillation as an Independent Predictor of Death and Coronary Events in Patients Having Coronary Angiography</title><author>Marte, Thomas, MD ; Saely, Christoph H., MD ; Schmid, Fabian, MD ; Koch, Lorena, MD ; Drexel, Heinz, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-7bbbd6b47bd6a23ffe07497991d161c5dc3224dd65dd66cc66b5e67263ea08413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Atrial Fibrillation - complications</topic><topic>Atrial Fibrillation - mortality</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Austria - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular system</topic><topic>Coronary Angiography</topic><topic>Coronary Disease - complications</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Coronary Disease - physiopathology</topic><topic>Coronary heart disease</topic><topic>Death, Sudden, Cardiac - epidemiology</topic><topic>Death, Sudden, Cardiac - etiology</topic><topic>Deaths</topic><topic>Effectiveness studies</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Humans</topic><topic>Incidence</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Survival Rate - trends</topic><topic>Time Factors</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marte, Thomas, MD</creatorcontrib><creatorcontrib>Saely, Christoph H., MD</creatorcontrib><creatorcontrib>Schmid, Fabian, MD</creatorcontrib><creatorcontrib>Koch, Lorena, MD</creatorcontrib><creatorcontrib>Drexel, Heinz, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marte, Thomas, MD</au><au>Saely, Christoph H., MD</au><au>Schmid, Fabian, MD</au><au>Koch, Lorena, MD</au><au>Drexel, Heinz, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of Atrial Fibrillation as an Independent Predictor of Death and Coronary Events in Patients Having Coronary Angiography</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2009</date><risdate>2009</risdate><volume>103</volume><issue>1</issue><spage>36</spage><epage>40</epage><pages>36-40</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>The impact of atrial fibrillation (AF) on future coronary events is uncertain. In particular, the prognostic impact of AF in the clinically important population of coronary patients who undergo angiography is unknown. The aim of this study was to investigate (1) the prevalence of AF, (2) its association with coronary atherosclerosis, and (3) its impact on future coronary events in patients who undergo angiography. Electrocardiograms were evaluated in a consecutive series of 613 patients who underwent coronary angiography. Prospectively, death and cardiovascular events were recorded over 4.0 ± 0.6 years. Among these patients, 37 (6%) at baseline had AF, and 576 (94%) were in sinus rhythm. The presence of AF was associated with a lower prevalence of coronary artery disease and of coronary diameter narrowing ≥50% on baseline angiography. However, prospectively, patients with AF were at a strongly increased risk for all-cause mortality (adjusted hazard ratio 5.15, 95% confidence interval 2.36 to 11.26, p <0.001), coronary death (hazard ratio 8.16, 95% confidence interval 2.89 to 23.09, p <0.001), and major coronary events (hazard ratio 3.80, 95% confidence interval 1.45 to 9.94, p = 0.007). In conclusion, although inversely associated with the presence of angiographically determined coronary atherosclerosis, AF is a strong predictor of death and future coronary events in patients with coronary artery disease who undergo coronary angiography.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>19101226</pmid><doi>10.1016/j.amjcard.2008.08.028</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Atrial Fibrillation - complications Atrial Fibrillation - mortality Atrial Fibrillation - physiopathology Austria - epidemiology Biological and medical sciences Cardiac arrhythmia Cardiac dysrhythmias Cardiology Cardiology. Vascular system Cardiovascular Cardiovascular disease Cardiovascular system Coronary Angiography Coronary Disease - complications Coronary Disease - diagnostic imaging Coronary Disease - physiopathology Coronary heart disease Death, Sudden, Cardiac - epidemiology Death, Sudden, Cardiac - etiology Deaths Effectiveness studies Electrocardiography Female Follow-Up Studies Heart Humans Incidence Investigative techniques, diagnostic techniques (general aspects) Male Medical prognosis Medical sciences Middle Aged Prognosis Prospective Studies Radiodiagnosis. Nmr imagery. Nmr spectrometry Risk Assessment Risk Factors Survival Rate - trends Time Factors Ultrasonic imaging |
| title | Effectiveness of Atrial Fibrillation as an Independent Predictor of Death and Coronary Events in Patients Having Coronary Angiography |
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