Cutaneous expression of systemic candidiasis
Summary Skin lesions associated with Candida septicaemia occur only in a minority of patients, who are usually immunocompromised, but they can help to establish a diagnosis rapidly. The lesions form a characteristic maculopapular or nodular rash at the onset of the infection. We report three cases o...
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| Veröffentlicht in: | Clinical and experimental dermatology 2009-01, Vol.34 (1), p.106-110 |
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| container_title | Clinical and experimental dermatology |
| container_volume | 34 |
| creator | Pedraz, J. Delgado-Jiménez, Y. Pérez-Gala, S. Nam-Cha, S. Fernández-Herrera, J. García-Diez, A. |
| description | Summary
Skin lesions associated with Candida septicaemia occur only in a minority of patients, who are usually immunocompromised, but they can help to establish a diagnosis rapidly. The lesions form a characteristic maculopapular or nodular rash at the onset of the infection. We report three cases of systemic candidiasis (SC) with cutaneous manifestations in immunocompromised patients. In these patients, the lesions started as asymptomatic or slightly pruriginous macules, papules or nodules localized on the trunk and extremities. The patients' general condition was very poor and they presented a high fever at the onset of the illness. Candida spp. were isolated from blood in all cases, and histology showed yeasts in two of them. Most of the lesions resolved with antifungal treatment. The diagnosis of SC is often delayed or missed because of the absence of useful diagnostic tools, the varying clinical manifestations and the frequent negativity (50–75%) of blood cultures for Candida. Fluconazole is the treatment of choice for Candida albicans, but treatment response is unknown for other Candida spp., which may require treatment with amphotericin B. |
| doi_str_mv | 10.1111/j.1365-2230.2007.02524.x |
| format | Article |
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Skin lesions associated with Candida septicaemia occur only in a minority of patients, who are usually immunocompromised, but they can help to establish a diagnosis rapidly. The lesions form a characteristic maculopapular or nodular rash at the onset of the infection. We report three cases of systemic candidiasis (SC) with cutaneous manifestations in immunocompromised patients. In these patients, the lesions started as asymptomatic or slightly pruriginous macules, papules or nodules localized on the trunk and extremities. The patients' general condition was very poor and they presented a high fever at the onset of the illness. Candida spp. were isolated from blood in all cases, and histology showed yeasts in two of them. Most of the lesions resolved with antifungal treatment. The diagnosis of SC is often delayed or missed because of the absence of useful diagnostic tools, the varying clinical manifestations and the frequent negativity (50–75%) of blood cultures for Candida. Fluconazole is the treatment of choice for Candida albicans, but treatment response is unknown for other Candida spp., which may require treatment with amphotericin B.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/j.1365-2230.2007.02524.x</identifier><identifier>PMID: 19076813</identifier><identifier>CODEN: CEDEDE</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Amphotericin B - therapeutic use ; Antifungal Agents - therapeutic use ; Biological and medical sciences ; Biopsy ; Candida albicans ; Candidiasis, Cutaneous - diagnosis ; Candidiasis, Cutaneous - drug therapy ; Dermatology ; Female ; Fluconazole - therapeutic use ; Humans ; Immunocompromised Host ; Male ; Medical sciences ; Middle Aged ; Risk Factors ; Sepsis - microbiology</subject><ispartof>Clinical and experimental dermatology, 2009-01, Vol.34 (1), p.106-110</ispartof><rights>2008 The Author(s). Journal compilation © 2008 Blackwell Publishing Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5164-ba0103e875e0cbd8f2861bc1b2790f69182181c2e07e73fc97ae07c1e9ff3ede3</citedby><cites>FETCH-LOGICAL-c5164-ba0103e875e0cbd8f2861bc1b2790f69182181c2e07e73fc97ae07c1e9ff3ede3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20947991$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19076813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pedraz, J.</creatorcontrib><creatorcontrib>Delgado-Jiménez, Y.</creatorcontrib><creatorcontrib>Pérez-Gala, S.</creatorcontrib><creatorcontrib>Nam-Cha, S.</creatorcontrib><creatorcontrib>Fernández-Herrera, J.</creatorcontrib><creatorcontrib>García-Diez, A.</creatorcontrib><title>Cutaneous expression of systemic candidiasis</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
Skin lesions associated with Candida septicaemia occur only in a minority of patients, who are usually immunocompromised, but they can help to establish a diagnosis rapidly. The lesions form a characteristic maculopapular or nodular rash at the onset of the infection. We report three cases of systemic candidiasis (SC) with cutaneous manifestations in immunocompromised patients. In these patients, the lesions started as asymptomatic or slightly pruriginous macules, papules or nodules localized on the trunk and extremities. The patients' general condition was very poor and they presented a high fever at the onset of the illness. Candida spp. were isolated from blood in all cases, and histology showed yeasts in two of them. Most of the lesions resolved with antifungal treatment. The diagnosis of SC is often delayed or missed because of the absence of useful diagnostic tools, the varying clinical manifestations and the frequent negativity (50–75%) of blood cultures for Candida. Fluconazole is the treatment of choice for Candida albicans, but treatment response is unknown for other Candida spp., which may require treatment with amphotericin B.</description><subject>Adult</subject><subject>Amphotericin B - therapeutic use</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Candida albicans</subject><subject>Candidiasis, Cutaneous - diagnosis</subject><subject>Candidiasis, Cutaneous - drug therapy</subject><subject>Dermatology</subject><subject>Female</subject><subject>Fluconazole - therapeutic use</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Sepsis - microbiology</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV1v0zAUhi3ExMq2v4ByA1ckO8du_HHBBQtjTJpgQkyTdmM5zrHkkjYlbkX770lI1V2Cb3wkP6_96jFjGUKBw7pcFChkmXMuoOAAqgBe8nmxe8Fmx4OXbAYCVC6N0KfsdUoLABSoylfsFA0oqVHM2Ptqu3Er6rYpo926p5Rit8q6kKV92tAy-sy7VROb6FJM5-wkuDbRxWE_Yw-fr39UX_K7bze31ce73Jco53ntAEGQViWBrxsduJZYe6y5MhCkQc1Ro-cEipQI3ig3jB7JhCCoIXHG3k33rvvu15bSxi5j8tS2U1MrpZrzstT_BDnwoQWMoJ5A33cp9RTsuo9L1-8tgh2V2oUdzdnRnB2V2r9K7W6Ivjm8sa2X1DwHDw4H4O0BcMm7NvRu5WM6chzMXBmDA_dh4n7Hlvb_XcBW15_GacjnUz4OP7M75l3_00olVGkfv97Yp3t8vLr6_mQr8QedwZ_h</recordid><startdate>200901</startdate><enddate>200901</enddate><creator>Pedraz, J.</creator><creator>Delgado-Jiménez, Y.</creator><creator>Pérez-Gala, S.</creator><creator>Nam-Cha, S.</creator><creator>Fernández-Herrera, J.</creator><creator>García-Diez, A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>200901</creationdate><title>Cutaneous expression of systemic candidiasis</title><author>Pedraz, J. ; Delgado-Jiménez, Y. ; Pérez-Gala, S. ; Nam-Cha, S. ; Fernández-Herrera, J. ; García-Diez, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5164-ba0103e875e0cbd8f2861bc1b2790f69182181c2e07e73fc97ae07c1e9ff3ede3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Amphotericin B - therapeutic use</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Candida albicans</topic><topic>Candidiasis, Cutaneous - diagnosis</topic><topic>Candidiasis, Cutaneous - drug therapy</topic><topic>Dermatology</topic><topic>Female</topic><topic>Fluconazole - therapeutic use</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Sepsis - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pedraz, J.</creatorcontrib><creatorcontrib>Delgado-Jiménez, Y.</creatorcontrib><creatorcontrib>Pérez-Gala, S.</creatorcontrib><creatorcontrib>Nam-Cha, S.</creatorcontrib><creatorcontrib>Fernández-Herrera, J.</creatorcontrib><creatorcontrib>García-Diez, A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pedraz, J.</au><au>Delgado-Jiménez, Y.</au><au>Pérez-Gala, S.</au><au>Nam-Cha, S.</au><au>Fernández-Herrera, J.</au><au>García-Diez, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cutaneous expression of systemic candidiasis</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>2009-01</date><risdate>2009</risdate><volume>34</volume><issue>1</issue><spage>106</spage><epage>110</epage><pages>106-110</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><coden>CEDEDE</coden><abstract>Summary
Skin lesions associated with Candida septicaemia occur only in a minority of patients, who are usually immunocompromised, but they can help to establish a diagnosis rapidly. The lesions form a characteristic maculopapular or nodular rash at the onset of the infection. We report three cases of systemic candidiasis (SC) with cutaneous manifestations in immunocompromised patients. In these patients, the lesions started as asymptomatic or slightly pruriginous macules, papules or nodules localized on the trunk and extremities. The patients' general condition was very poor and they presented a high fever at the onset of the illness. Candida spp. were isolated from blood in all cases, and histology showed yeasts in two of them. Most of the lesions resolved with antifungal treatment. The diagnosis of SC is often delayed or missed because of the absence of useful diagnostic tools, the varying clinical manifestations and the frequent negativity (50–75%) of blood cultures for Candida. Fluconazole is the treatment of choice for Candida albicans, but treatment response is unknown for other Candida spp., which may require treatment with amphotericin B.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19076813</pmid><doi>10.1111/j.1365-2230.2007.02524.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Amphotericin B - therapeutic use Antifungal Agents - therapeutic use Biological and medical sciences Biopsy Candida albicans Candidiasis, Cutaneous - diagnosis Candidiasis, Cutaneous - drug therapy Dermatology Female Fluconazole - therapeutic use Humans Immunocompromised Host Male Medical sciences Middle Aged Risk Factors Sepsis - microbiology |
| title | Cutaneous expression of systemic candidiasis |
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