Influence of Stabilizers on the Physicochemical Characteristics of Inhaled Insulin Powders Produced by Supercritical Antisolvent Process

Purpose To examine the effect of stabilizers on aerosol physicochemical characteristics of inhaled insulin particles produced using a supercritical fluid technology. Materials and Methods Insulin with stabilizers such as mannitol and trehalose was micronized by aerosol solvent extraction system (ASE...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmaceutical research 2009, Vol.26 (1), p.61-71
Hauptverfasser:	Kim, Yong Ho, Sioutas, Constantinos, Shing, Katherine S
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Aerosols Biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Chemistry, Pharmaceutical Chromatography, Supercritical Fluid Crystallization Crystallography, X-Ray Drug delivery systems Engineering and Processing Excipients - chemistry Formulation Design General pharmacology Humidity Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - chemistry Indicators and Reagents Insulin Insulin - administration & dosage Insulin - chemistry Lungs Mannitol - chemistry Medical Law Medical sciences Microscopy, Electron, Scanning Particle Size Pharmaceutical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Powders pulmonary delivery Solvents Spectrophotometry, Ultraviolet Spectroscopy, Fourier Transform Infrared stabilizer supercritical antisolvent
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!