Kinetics of selected di- n -butyl phthalate metabolites and fetal testosterone following repeated and single administration in pregnant rats

Abstract Human exposure to phthalic acid diesters occurs through a variety of pathways as a result of their widespread use in consumer products and plastics. Repeated doses of di- n -butyl phthalate (DBP) from gestation day (GD) 12 to 19 disrupt testosterone synthesis and male sexual development in...

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Veröffentlicht in:	Toxicology (Amsterdam) 2009-01, Vol.255 (1), p.80-90
Hauptverfasser:	Clewell, Rebecca A, Kremer, John J, Williams, Carla C, Campbell, Jerry L, Sochaski, Mark A, Andersen, Melvin E, Borghoff, Susan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amniotic Fluid - metabolism Animals Area Under Curve Biological and medical sciences Biomarkers Calibration Chromatography, High Pressure Liquid DBP Dibutyl Phthalate - pharmacokinetics Dose-Response Relationship, Drug Emergency Female Fetus - metabolism Gas Chromatography-Mass Spectrometry Gestation Indicators and Reagents Kinetics Liver - metabolism Male Mass Spectrometry Medical sciences Phthalate Phthalic Acids - pharmacokinetics Placenta - metabolism Pregnancy Quality Control Quinolines Rats Rats, Sprague-Dawley Sexual Maturation - drug effects Testis - drug effects Testis - embryology Testis - metabolism Testosterone Testosterone - metabolism Toxicology
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