CD44s Expression, in Benign, Borderline and Malignant Tumors of Ovarian Surface Epithelium. Correlation with p53, Steroid Receptor Status, Proliferative Indices (PCNA, MIB1) and Survival

Aim: To investigate the role of CD44s in the biological behavior of surface epithelial ovarian tumors and its correlation with clinicopathological parameters, prognosis, p53, steroid receptor status and proliferative indices (PCNA, MIB1). Materials and Methods: We analyzed a total of 83 patients wit...

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Veröffentlicht in:	Anticancer research 2004-05, Vol.24 (3A), p.1665-1670
Hauptverfasser:	ZAGORIANAKOU, N, STEFANOU, D, MAKRYDIMAS, G, ZAGORIANAKOU, P, BRIASOULIS, E, KARAVASILIS, B, AGNANTIS, N. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Cell Division - physiology Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Hyaluronan Receptors - biosynthesis Immunohistochemistry Ki-67 Antigen - biosynthesis Medical sciences Middle Aged Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Proliferating Cell Nuclear Antigen - biosynthesis Receptors, Estrogen - biosynthesis Receptors, Progesterone - biosynthesis Survival Rate Tumor Suppressor Protein p53 - biosynthesis Tumors
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Zusammenfassung:	Aim: To investigate the role of CD44s in the biological behavior of surface epithelial ovarian tumors and its correlation with clinicopathological parameters, prognosis, p53, steroid receptor status and proliferative indices (PCNA, MIB1). Materials and Methods: We analyzed a total of 83 patients with ovarian surface epithelial tumors, for the immunohistochemical expression of CD44s and the possible correlation with clinicopathological factors and patients' outcome. Results: A statistically significant correlation was found between the expression of CD44s, which was higher in cancer cases than in benign cystadenomas (p
ISSN:	0250-7005 1791-7530