Assessment of microvessel density and carbonic anhydrase-9 (CA-9) expression in rectal cancer

The mechanism by which neoplasias respond to hypoxia determines their biological behavior and prognosis. Understanding the biology of tumors under hypoxic conditions is crucial for the development of anti-angiogenic therapy. Using the largest cohort of rectal adenocarcinomas to date, this study aime...

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Veröffentlicht in:	Pathology, research and practice research and practice, 2009-01, Vol.205 (1), p.1-9
Hauptverfasser:	Rasheed, S., Harris, A.L., Tekkis, P.P., Turley, H., Silver, A., McDonald, P.J., Talbot, I.C., Glynne-Jones, R., Northover, J.M.A., Guenther, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - blood supply Adenocarcinoma - enzymology Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - surgery Aged Angiogenesis Antigens, Neoplasm - analysis Biomarkers, Tumor - analysis Carbonic Anhydrase IX Carbonic anhydrase-9 Carbonic Anhydrases - analysis Disease-Free Survival Female Humans Hypoxia Kaplan-Meier Estimate Male Microvessel density Microvessels - pathology Middle Aged Neoplasm Invasiveness Neoplasm Staging Proportional Hazards Models Rectal cancer Rectal Neoplasms - blood supply Rectal Neoplasms - enzymology Rectal Neoplasms - mortality Rectal Neoplasms - pathology Rectal Neoplasms - surgery Recurrence Risk Assessment Time Factors Treatment Outcome
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