Neurogenesis and depression: etiology or epiphenomenon?
The concept that decreased neurogenesis might be the cause of depression is supported by the effects of stress on neurogenesis and the demonstration that neurogenesis seems to be necessary for antidepressant action. Data from the animal models tested to date show that decreasing the rate of neurogen...
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| Veröffentlicht in: | Biological psychiatry (1969) 2004-08, Vol.56 (3), p.146-150 |
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| container_title | Biological psychiatry (1969) |
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| creator | Henn, Fritz A Vollmayr, Barbara |
| description | The concept that decreased neurogenesis might be the cause of depression is supported by the effects of stress on neurogenesis and the demonstration that neurogenesis seems to be necessary for antidepressant action. Data from the animal models tested to date show that decreasing the rate of neurogenesis does not lead to depressive behavior. Furthermore, evidence shows that an effective treatment for depression, transcranial magnetic stimulation, does not alter rates of neurogenesis. On the basis of these findings, it is suggested that neurogenesis might play a subtle role in depression but that it is not the primary factor in the final common pathway leading to depression. |
| doi_str_mv | 10.1016/j.biopsych.2004.04.011 |
| format | Article |
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Data from the animal models tested to date show that decreasing the rate of neurogenesis does not lead to depressive behavior. Furthermore, evidence shows that an effective treatment for depression, transcranial magnetic stimulation, does not alter rates of neurogenesis. On the basis of these findings, it is suggested that neurogenesis might play a subtle role in depression but that it is not the primary factor in the final common pathway leading to depression.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/j.biopsych.2004.04.011</identifier><identifier>PMID: 15271582</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult and adolescent clinical studies ; animal models ; Animals ; antidepressants ; Antidepressive Agents - therapeutic use ; Behavioral psychophysiology ; behavioral responses ; Biological and medical sciences ; Brain - pathology ; Cell Division - physiology ; Depression ; Depression - drug therapy ; Depression - epidemiology ; Depression - etiology ; Disease Models, Animal ; Fundamental and applied biological sciences. Psychology ; Humans ; Medical sciences ; Miscellaneous ; Mood disorders ; neurogenesis ; Neurons - pathology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. 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Data from the animal models tested to date show that decreasing the rate of neurogenesis does not lead to depressive behavior. Furthermore, evidence shows that an effective treatment for depression, transcranial magnetic stimulation, does not alter rates of neurogenesis. On the basis of these findings, it is suggested that neurogenesis might play a subtle role in depression but that it is not the primary factor in the final common pathway leading to depression.</description><subject>Adult and adolescent clinical studies</subject><subject>animal models</subject><subject>Animals</subject><subject>antidepressants</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Behavioral psychophysiology</subject><subject>behavioral responses</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Cell Division - physiology</subject><subject>Depression</subject><subject>Depression - drug therapy</subject><subject>Depression - epidemiology</subject><subject>Depression - etiology</subject><subject>Disease Models, Animal</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Mood disorders</subject><subject>neurogenesis</subject><subject>Neurons - pathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopathology. 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| ispartof | Biological psychiatry (1969), 2004-08, Vol.56 (3), p.146-150 |
| issn | 0006-3223 1873-2402 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult and adolescent clinical studies animal models Animals antidepressants Antidepressive Agents - therapeutic use Behavioral psychophysiology behavioral responses Biological and medical sciences Brain - pathology Cell Division - physiology Depression Depression - drug therapy Depression - epidemiology Depression - etiology Disease Models, Animal Fundamental and applied biological sciences. Psychology Humans Medical sciences Miscellaneous Mood disorders neurogenesis Neurons - pathology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Stress, Physiological - drug therapy Stress, Physiological - physiopathology Time Factors |
| title | Neurogenesis and depression: etiology or epiphenomenon? |
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