Timing and Targeting of Cell-Based VEGF165 Gene Expression in Ischemic Tissue

Background Therapeutic angiogenesis has become a key technology in experimental and clinical medicine. Only few data are available on the effects of timing and targeting of therapeutic proteins after cell-based gene transfer. This work investigates such effects after temporary expression of vascular...

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Veröffentlicht in:	The Journal of surgical research 2009, Vol.151 (1), p.153-162
Hauptverfasser:	Spanholtz, Timo, M.D, Maichle, Alexandra, M.D, Niedworok, Christian, M.D, Stoeckelhuber, Beate M., M.D, Krüger, Stefan, Wedel, Thilo, M.D, Aach, Til, M.D, Middeler, Guido, M.D, Hellwig-Bürgel, Thomas, Ph.D, Bader, Augustinus, M.D, Krengel, Sven, Ph.D, Müller, Oliver J., M.D, Franz, Wolfgang M., M.D, Lindenmaier, Werner, Ph.D, Machens, Hans-Guenther, M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Animals Biological and medical sciences Cell Proliferation Endothelium, Vascular - cytology Endothelium, Vascular - physiology Female Fibroblasts - cytology Fibroblasts - metabolism Gene Expression Regulation - physiology Gene Transfer Techniques General aspects Genetic Therapy - methods Ischemia - metabolism Ischemia - pathology Medical sciences Models, Animal Neovascularization, Physiologic - physiology Rats Rats, Sprague-Dawley Surgery Surgical Flaps - blood supply Time Factors Transfection Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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