Effects of acupuncture on myelogenic osteoclastogenesis and IL-6 mRNA expression
The effect of acupuncture and moxibustion on myelogenic osteoclastogenesis and IL-6 mRNA expression is investigated. The result turns to be that the number of myelogenic osteoclasts in the model group is obviously bigger than in the sham operation group (P
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| Veröffentlicht in: | Journal of traditional Chinese medicine 2004-06, Vol.24 (2), p.144-148 |
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| container_title | Journal of traditional Chinese medicine |
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| creator | Liu, Xianxiang Shen, Lin Wu, Mingxia Wu, Binghuang Gao, Lan Hu, Wensheng Zhang, Anzhen |
| description | The effect of acupuncture and moxibustion on myelogenic osteoclastogenesis and IL-6 mRNA expression is investigated. The result turns to be that the number of myelogenic osteoclasts in the model group is obviously bigger than in the sham operation group (P |
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The result turns to be that the number of myelogenic osteoclasts in the model group is obviously bigger than in the sham operation group (P<0.01), and that in the acupuncture group is markedly smaller than in the model group (P<0.01). The IL-6 mRNA expression in the marrow cells of the model group is significantly elevated, as compared with that in the sham operation group (P<0.01), while the its elevation is lower in the acupuncture group than in the model group (P<0.01). It is therefore concluded that 1) acupuncture effectively modulates the secretion of and then to reduces IL-6 mRNA expression and 2) acupuncture decreases the number of myelogenic osteoclasts.</description><identifier>ISSN: 0255-2922</identifier><identifier>PMID: 15270274</identifier><language>eng</language><publisher>China</publisher><subject>Acupuncture ; Animals ; Bone Marrow Cells - metabolism ; Bone Resorption ; Female ; Interleukin-6 - biosynthesis ; Interleukin-6 - genetics ; Moxibustion ; Osteoclasts - pathology ; Osteoclasts - physiology ; Osteogenesis ; Osteoporosis - etiology ; Osteoporosis - metabolism ; Osteoporosis - pathology ; Ovariectomy ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics</subject><ispartof>Journal of traditional Chinese medicine, 2004-06, Vol.24 (2), p.144-148</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15270274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Xianxiang</creatorcontrib><creatorcontrib>Shen, Lin</creatorcontrib><creatorcontrib>Wu, Mingxia</creatorcontrib><creatorcontrib>Wu, Binghuang</creatorcontrib><creatorcontrib>Gao, Lan</creatorcontrib><creatorcontrib>Hu, Wensheng</creatorcontrib><creatorcontrib>Zhang, Anzhen</creatorcontrib><title>Effects of acupuncture on myelogenic osteoclastogenesis and IL-6 mRNA expression</title><title>Journal of traditional Chinese medicine</title><addtitle>J Tradit Chin Med</addtitle><description>The effect of acupuncture and moxibustion on myelogenic osteoclastogenesis and IL-6 mRNA expression is investigated. The result turns to be that the number of myelogenic osteoclasts in the model group is obviously bigger than in the sham operation group (P<0.01), and that in the acupuncture group is markedly smaller than in the model group (P<0.01). The IL-6 mRNA expression in the marrow cells of the model group is significantly elevated, as compared with that in the sham operation group (P<0.01), while the its elevation is lower in the acupuncture group than in the model group (P<0.01). It is therefore concluded that 1) acupuncture effectively modulates the secretion of and then to reduces IL-6 mRNA expression and 2) acupuncture decreases the number of myelogenic osteoclasts.</description><subject>Acupuncture</subject><subject>Animals</subject><subject>Bone Marrow Cells - metabolism</subject><subject>Bone Resorption</subject><subject>Female</subject><subject>Interleukin-6 - biosynthesis</subject><subject>Interleukin-6 - genetics</subject><subject>Moxibustion</subject><subject>Osteoclasts - pathology</subject><subject>Osteoclasts - physiology</subject><subject>Osteogenesis</subject><subject>Osteoporosis - etiology</subject><subject>Osteoporosis - metabolism</subject><subject>Osteoporosis - pathology</subject><subject>Ovariectomy</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><issn>0255-2922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEFLwzAYhnNQ3Jz-BcnJWyH5uiTNcYypg6Eiei5J-kUqbVP7NeD-vYrz9MDLw3t4zthSgFIFWIAFuyT6EEJVSlUXbCEVGAFmvWTPuxgxzMRT5C7kMQ9hzhPyNPD-iF16x6ENPNGMKXSO5t8BqSXuhobvD4Xm_cvjhuPXOCFRm4Yrdh5dR3h94oq93e1etw_F4el-v90cilECzAV6JT3a0lurrTfao7JGyCqC1k0wxgVQUQoRI0hTCaNRNnrtvRPCGlXGcsVu_37HKX1mpLnuWwrYdW7AlKnW2pQKQPyINycx-x6bepza3k3H-r9B-Q2xr1cB</recordid><startdate>200406</startdate><enddate>200406</enddate><creator>Liu, Xianxiang</creator><creator>Shen, Lin</creator><creator>Wu, Mingxia</creator><creator>Wu, Binghuang</creator><creator>Gao, Lan</creator><creator>Hu, Wensheng</creator><creator>Zhang, Anzhen</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200406</creationdate><title>Effects of acupuncture on myelogenic osteoclastogenesis and IL-6 mRNA expression</title><author>Liu, Xianxiang ; Shen, Lin ; Wu, Mingxia ; Wu, Binghuang ; Gao, Lan ; Hu, Wensheng ; Zhang, Anzhen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p122t-eb51be93b9969b76be597018f266dc77ac25f100ff2178076e1d64bba009753f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acupuncture</topic><topic>Animals</topic><topic>Bone Marrow Cells - metabolism</topic><topic>Bone Resorption</topic><topic>Female</topic><topic>Interleukin-6 - biosynthesis</topic><topic>Interleukin-6 - genetics</topic><topic>Moxibustion</topic><topic>Osteoclasts - pathology</topic><topic>Osteoclasts - physiology</topic><topic>Osteogenesis</topic><topic>Osteoporosis - etiology</topic><topic>Osteoporosis - metabolism</topic><topic>Osteoporosis - pathology</topic><topic>Ovariectomy</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Xianxiang</creatorcontrib><creatorcontrib>Shen, Lin</creatorcontrib><creatorcontrib>Wu, Mingxia</creatorcontrib><creatorcontrib>Wu, Binghuang</creatorcontrib><creatorcontrib>Gao, Lan</creatorcontrib><creatorcontrib>Hu, Wensheng</creatorcontrib><creatorcontrib>Zhang, Anzhen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of traditional Chinese medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Xianxiang</au><au>Shen, Lin</au><au>Wu, Mingxia</au><au>Wu, Binghuang</au><au>Gao, Lan</au><au>Hu, Wensheng</au><au>Zhang, Anzhen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of acupuncture on myelogenic osteoclastogenesis and IL-6 mRNA expression</atitle><jtitle>Journal of traditional Chinese medicine</jtitle><addtitle>J Tradit Chin Med</addtitle><date>2004-06</date><risdate>2004</risdate><volume>24</volume><issue>2</issue><spage>144</spage><epage>148</epage><pages>144-148</pages><issn>0255-2922</issn><abstract>The effect of acupuncture and moxibustion on myelogenic osteoclastogenesis and IL-6 mRNA expression is investigated. The result turns to be that the number of myelogenic osteoclasts in the model group is obviously bigger than in the sham operation group (P<0.01), and that in the acupuncture group is markedly smaller than in the model group (P<0.01). The IL-6 mRNA expression in the marrow cells of the model group is significantly elevated, as compared with that in the sham operation group (P<0.01), while the its elevation is lower in the acupuncture group than in the model group (P<0.01). It is therefore concluded that 1) acupuncture effectively modulates the secretion of and then to reduces IL-6 mRNA expression and 2) acupuncture decreases the number of myelogenic osteoclasts.</abstract><cop>China</cop><pmid>15270274</pmid><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acupuncture Animals Bone Marrow Cells - metabolism Bone Resorption Female Interleukin-6 - biosynthesis Interleukin-6 - genetics Moxibustion Osteoclasts - pathology Osteoclasts - physiology Osteogenesis Osteoporosis - etiology Osteoporosis - metabolism Osteoporosis - pathology Ovariectomy Random Allocation Rats Rats, Sprague-Dawley RNA, Messenger - biosynthesis RNA, Messenger - genetics |
| title | Effects of acupuncture on myelogenic osteoclastogenesis and IL-6 mRNA expression |
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