Protochlorophyllide: a new photosensitizer for the photodynamic inactivation of Gram-positive and Gram-negative bacteria

Abstract The growing resistance against antibiotics demands the search for alternative treatment strategies. Photodynamic therapy is a promising candidate. The natural intermediate of chlorophyll biosynthesis, protochlorophyllide, was produced, purified and tested as a novel photosensitizer for the...

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Veröffentlicht in:	FEMS microbiology letters 2009-01, Vol.290 (2), p.156-163
Hauptverfasser:	Walther, Johannes, Bröcker, Markus J., Wätzlich, Denise, Nimtz, Manfred, Rohde, Manfred, Jahn, Dieter, Moser, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Action of physical and chemical agents on bacteria Antibiotics Bacillus subtilis Bacteria Bacteria - drug effects Bacteria - radiation effects Bacterial Infections - drug therapy Bacteriology Biological and medical sciences Biosynthesis Cell division Chlorophyll Cytoplasm Deactivation E coli Escherichia coli Filamentous microorganisms Fundamental and applied biological sciences. Psychology Gram-negative bacteria Humans Inactivation Listeria Listeria monocytogenes Membrane permeability Microbial Sensitivity Tests Microbial Viability - drug effects Microbial Viability - radiation effects Microbiology Microorganisms Photochemotherapy Photodynamic therapy Photosensitizing Agents - pharmacology Polymyxin B Protochlorophyllide Protochlorophyllide - pharmacology Pseudotuberculosis Septum Staphylococcus aureus Transmission electron microscopy Tungsten White light Yersinia pseudotuberculosis
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