Dose–Response Relationships in an Olfactory Flux Detector Model Revisited
A simple model of an odorant flux detector including odorant uptake, activation of odorant receptor molecules and enzymatic odorant deactivation can produce different types of static dose–response relationships. Depending on the binding characteristics of the odorant to the receptor molecule and to...
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| Veröffentlicht in: | Chemical senses 2004-07, Vol.29 (6), p.529-531 |
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| creator | Kaissling, Karl-Ernst Rospars, Jean-Pierre |
| description | A simple model of an odorant flux detector including odorant uptake, activation of odorant receptor molecules and enzymatic odorant deactivation can produce different types of static dose–response relationships. Depending on the binding characteristics of the odorant to the receptor molecule and to the deactivating enzyme, the receptor occupation by the odorant as related to the odorant uptake is quasi-hyperbolic, linear or, close to saturation, steeper than linear. In Rospars et al. (2003, Chem. Senses, 28: 509–522) a note contributed by both of us stated erroneously that an equation describing these relationships given previously (Kaissling, 1998, Chem. Senses, 23; 99–111; Kaissling, 2001, Chem. Senses, 26: 125–150) was incorrect. We show here that the difference in equations was due to a simplifying assumption in Rospars et al. (2003) about the deactivating enzyme, we summarize briefly the properties of the correct equation of Kaissling (1998, 2001) and we discuss the relation with the model studied in Rospars et al. (2003). |
| doi_str_mv | 10.1093/chemse/bjh057 |
| format | Article |
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Gustatory system and gustation ; pulsed odorant stimulation ; receptor occupation modeling ; Receptors, Odorant - agonists ; Receptors, Odorant - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Chemical senses, 2004-07, Vol.29 (6), p.529-531</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Jul 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-65c758f1b4d85e1bbd56f1425e235ec99ada840f9613037c99c202ed0cb5538a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15969536$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15269125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaissling, Karl-Ernst</creatorcontrib><creatorcontrib>Rospars, Jean-Pierre</creatorcontrib><title>Dose–Response Relationships in an Olfactory Flux Detector Model Revisited</title><title>Chemical senses</title><addtitle>Chem. Senses</addtitle><description>A simple model of an odorant flux detector including odorant uptake, activation of odorant receptor molecules and enzymatic odorant deactivation can produce different types of static dose–response relationships. Depending on the binding characteristics of the odorant to the receptor molecule and to the deactivating enzyme, the receptor occupation by the odorant as related to the odorant uptake is quasi-hyperbolic, linear or, close to saturation, steeper than linear. In Rospars et al. (2003, Chem. Senses, 28: 509–522) a note contributed by both of us stated erroneously that an equation describing these relationships given previously (Kaissling, 1998, Chem. Senses, 23; 99–111; Kaissling, 2001, Chem. Senses, 26: 125–150) was incorrect. We show here that the difference in equations was due to a simplifying assumption in Rospars et al. (2003) about the deactivating enzyme, we summarize briefly the properties of the correct equation of Kaissling (1998, 2001) and we discuss the relation with the model studied in Rospars et al. (2003).</description><subject>Biological and medical sciences</subject><subject>chemoreceptors</subject><subject>Dose-Response Relationship, Drug</subject><subject>dose–response relationships</subject><subject>Enzymes - metabolism</subject><subject>flux detectors</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Models, Biological</subject><subject>odorant deactivation</subject><subject>Odorants</subject><subject>Olfactory Mucosa - metabolism</subject><subject>Olfactory system and olfaction. Gustatory system and gustation</subject><subject>pulsed odorant stimulation</subject><subject>receptor occupation modeling</subject><subject>Receptors, Odorant - agonists</subject><subject>Receptors, Odorant - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0379-864X</issn><issn>1464-3553</issn><issn>1464-3553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ctuEzEUBmALgWgoLNmiERLshvo-9hI1lCCCKkUgRd1YHs8ZxWEyE3xmULvrO_QNeRJcJaKIDSvfPh_r9yHkJaPvGLXiLGxgh3BWbzdUVY_IjEktS6GUeExmVFS2NFquT8gzxC2lTApunpITpri2jKsZ-TwfEH7d3q0A90OPUKyg82PM003cYxH7wvfFZdf6MA7pprjoputiDiPcL4svQwNdvvEzYhyheU6etL5DeHEcT8m3iw9fzxfl8vLjp_P3yzJIJcdSq1Ap07JaNkYBq-tG6ZZJroALBcFa33gjaWs1EzlB3giccmhoqHMs48UpeXuou0_DjwlwdLuIAbrO9zBM6LSuBKeC_xcyQ6k2RmX4-h-4HabU5xCOWcu1FrLKqDygkAbEBK3bp7jz6cYx6u574Q69cIdeZP_qWHSqd9A86OPnZ_DmCDwG37XJ9yHiX85qq4R-eDjiCNd_zn367nLSSrnF-srN1XJ1tV4tnBa_AY82owI</recordid><startdate>20040701</startdate><enddate>20040701</enddate><creator>Kaissling, Karl-Ernst</creator><creator>Rospars, Jean-Pierre</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20040701</creationdate><title>Dose–Response Relationships in an Olfactory Flux Detector Model Revisited</title><author>Kaissling, Karl-Ernst ; Rospars, Jean-Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-65c758f1b4d85e1bbd56f1425e235ec99ada840f9613037c99c202ed0cb5538a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biological and medical sciences</topic><topic>chemoreceptors</topic><topic>Dose-Response Relationship, Drug</topic><topic>dose–response relationships</topic><topic>Enzymes - metabolism</topic><topic>flux detectors</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Models, Biological</topic><topic>odorant deactivation</topic><topic>Odorants</topic><topic>Olfactory Mucosa - metabolism</topic><topic>Olfactory system and olfaction. Gustatory system and gustation</topic><topic>pulsed odorant stimulation</topic><topic>receptor occupation modeling</topic><topic>Receptors, Odorant - agonists</topic><topic>Receptors, Odorant - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaissling, Karl-Ernst</creatorcontrib><creatorcontrib>Rospars, Jean-Pierre</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical senses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaissling, Karl-Ernst</au><au>Rospars, Jean-Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dose–Response Relationships in an Olfactory Flux Detector Model Revisited</atitle><jtitle>Chemical senses</jtitle><addtitle>Chem. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Free Full-Text Journals in Chemistry |
| subjects | Biological and medical sciences chemoreceptors Dose-Response Relationship, Drug dose–response relationships Enzymes - metabolism flux detectors Fundamental and applied biological sciences. Psychology Models, Biological odorant deactivation Odorants Olfactory Mucosa - metabolism Olfactory system and olfaction. Gustatory system and gustation pulsed odorant stimulation receptor occupation modeling Receptors, Odorant - agonists Receptors, Odorant - metabolism Vertebrates: nervous system and sense organs |
| title | Dose–Response Relationships in an Olfactory Flux Detector Model Revisited |
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