Substituted 3-Imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino- [6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as Highly Selective and Potent Inhibitors of Glycogen Synthase Kinase-3

Glycogen synthase kinase-3 (GSK3) is involved in signaling from the insulin receptor. Inhibitors of GSK3 are expected to effect lowering of plasma glucose similar to insulin, making GSK3 an attractive target for the treatment of type 2 diabetes. Herein we report the discovery of a series of potent a...

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Veröffentlicht in:	Journal of medicinal chemistry 2004-07, Vol.47 (16), p.3934-3937
Hauptverfasser:	Engler, Thomas A, Henry, James R, Malhotra, Sushant, Cunningham, Brian, Furness, Kelly, Brozinick, Joseph, Burkholder, Timothy P, Clay, Michael P, Clayton, Joshua, Diefenbacher, Clive, Hawkins, Eric, Iversen, Philip W, Li, Yihong, Lindstrom, Terry D, Marquart, Angela L, McLean, Johnathan, Mendel, David, Misener, Elizabeth, Briere, Daniel, O'Toole, John C, Porter, Warren J, Queener, Steven, Reel, Jon K, Owens, Rebecca A, Brier, Richard A, Eessalu, Thomas E, Wagner, Jill R, Campbell, Robert M, Vaughn, Renee
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Diabetes Mellitus, Type 2 - drug therapy Female General and cellular metabolism. Vitamins Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 beta Humans Imidazoles - chemical synthesis Imidazoles - pharmacokinetics Imidazoles - pharmacology Medical sciences Pharmacology. Drug treatments Pyridines - chemical synthesis Pyridines - pharmacokinetics Pyridines - pharmacology Pyrroles - chemical synthesis Pyrroles - pharmacokinetics Pyrroles - pharmacology Rats Rats, Zucker
Online-Zugang:	Volltext
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