c-Src-mediated phosphorylation of AP-2 reveals a general mechanism for receptors internalizing through the clathrin pathway

Clathrin-mediated endocytosis is a complex process regulated at many different levels. We showed previously that activation of the angiotensin type 1 receptor (AT1R), which belongs to the G protein-coupled receptor (GPCR) family, leads to c-Src-dependent tyrosine phosphorylation of β2-adaptin, a sub...

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Veröffentlicht in:	Cellular signalling 2009, Vol.21 (1), p.103-110
Hauptverfasser:	Zimmerman, Brandon, Simaan, May, Lee, Mi-Hye, Luttrell, Louis M., Laporte, Stéphane A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Protein Complex 2 - metabolism Adaptor Protein Complex beta Subunits - agonists Adaptor Protein Complex beta Subunits - metabolism Amino Acid Sequence Angiotensin II - pharmacology Animals AP-2 Arrestins - metabolism AT1R c-Src Cell Line Cercopithecus aethiops Clathrin Clathrin - metabolism Clathrin-Coated Vesicles - metabolism COS Cells EGF receptor Endocytosis Fluorescent Antibody Technique, Direct G protein-coupled receptors Gene Knockdown Techniques Humans Phosphorylation Protein-Tyrosine Kinases - metabolism Receptor, Angiotensin, Type 1 - metabolism Receptor, Epidermal Growth Factor - metabolism Receptors, G-Protein-Coupled - metabolism src-Family Kinases βarrestins
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