Allele-specific quantification of HLA-DQB1 gene expression by real-time reverse transcriptase-polymerase chain reaction

In addition to coding region polymorphism, allele-specific variation in the upstream regulatory region of the HLA-DQB1 gene has been detected. Reporter gene assays and transfection studies have indicated that HLA-DQB1 promoter polymorphism may be of functional significance. The aim of this study was...

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Veröffentlicht in:	Genes and immunity 2004-07, Vol.5 (5), p.405-416
Hauptverfasser:	Ferstl, B, Zacher, T, Lauer, B, Blagitko-Dorfs, N, Carl, A, Wassmuth, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Base Sequence Biomedical and Life Sciences Biomedicine Cancer Research Cell Differentiation - drug effects Cell Line Cytokines Cytokines - pharmacology Dendritic cells Dendritic Cells - metabolism DQB1 gene full-paper Gene Expression Gene Frequency - genetics Gene polymorphism Genetic aspects Heterozygote Histocompatibility antigen HLA Histocompatibility antigens HLA histocompatibility antigens HLA-DQ Antigens - biosynthesis HLA-DQ Antigens - genetics HLA-DQ beta-Chains Human Genetics Humans Immunology Molecular Sequence Data Monocytes Monocytes - drug effects Monocytes - metabolism Physiological aspects Polymerase chain reaction Polymorphism Polymorphism, Genetic Promoter Regions, Genetic - genetics Reporter gene Reverse Transcriptase Polymerase Chain Reaction RNA-directed DNA polymerase Transfection
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