Human alloantibody anti-Mart interferes with Mac-1–dependent leukocyte adhesion

The CD11b/CD18 integrin plays a crucial role in cell-cell adhesion processes. Recently, we described a case of severe neonatal alloimmune neutropenia (NAIN) caused by an alloantibody against a variant of the CD11b subunit (Mart alloantigen). Allele-specific transfected cells allowed us to demonstrat...

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Veröffentlicht in:	Blood 2004-08, Vol.104 (3), p.727-734
Hauptverfasser:	Sachs, Ulrich J.H., Chavakis, Triantafyllos, Fung, Lin, Lohrenz, Alexander, Bux, Jürgen, Reil, Angelika, Ruf, Andreas, Santoso, Sentot
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Blood Platelets - physiology CD18 Antigens - immunology Cell Adhesion - immunology Chlorocebus aethiops COS Cells DNA Primers Flow Cytometry Fundamental and applied biological sciences. Psychology Gene Frequency Genotype Glycation End Products, Advanced - physiology Granulocytes Humans Inflammation Intercellular Adhesion Molecule-1 - physiology Isoantibodies - immunology Isoantigens - immunology Macrophage-1 Antigen - physiology Molecular and cellular biology Neutrophils - physiology Polymerase Chain Reaction Transfection U937 Cells
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