The Chromosomal Passenger Complex Is Required for Chromatin-Induced Microtubule Stabilization and Spindle Assembly

In cells lacking centrosomes, such as those found in female meiosis, chromosomes must nucleate and stabilize microtubules in order to form a bipolar spindle. Here we report the identification of Dasra A and Dasra B, two new components of the vertebrate chromosomal passenger complex containing Incenp...

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Veröffentlicht in:	Cell 2004-07, Vol.118 (2), p.187-202
Hauptverfasser:	Sampath, Srinath C, Ohi, Ryoma, Leismann, Oliver, Salic, Adrian, Pozniakovski, Andrei, Funabiki, Hironori
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence - genetics Animals Aurora Kinase B Aurora Kinases Base Sequence - genetics Cell Division - physiology Cell Extracts Centromere - genetics Centromere - metabolism Chromatin - metabolism Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - isolation & purification Chromosomal Proteins, Non-Histone - metabolism Chromosome Structures - genetics Chromosome Structures - metabolism DNA, Complementary - analysis DNA, Complementary - genetics HeLa Cells Humans Inhibitor of Apoptosis Proteins Kinesin - genetics Kinesin - metabolism Macromolecular Substances Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Microtubules - genetics Microtubules - metabolism Molecular Sequence Data Neoplasm Proteins Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism ran GTP-Binding Protein - genetics ran GTP-Binding Protein - metabolism Sequence Homology, Nucleic Acid Spindle Apparatus - genetics Spindle Apparatus - metabolism Survivin Xenopus Xenopus Proteins - genetics Xenopus Proteins - isolation & purification Xenopus Proteins - metabolism
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