Structural and functional consequences of glutamine tract variation in the androgen receptor

The androgen receptor (AR) gene contains a polymorphic trinucleotide repeat region, (CAG)n, in its N-terminal transactivation domain (NTD) that encodes a polyglutamine (polyQ) tract in the receptor protein. Whereas the length of the CAG repeat ranges from 6 to 39 in healthy individuals, the variatio...

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Veröffentlicht in:	Human molecular genetics 2004-08, Vol.13 (16), p.1677-1692
Hauptverfasser:	Buchanan, Grant, Yang, Miao, Cheong, Albert, Harris, Jonathan M., Irvine, Ryan A., Lambert, Paul F., Moore, Nicole L., Raynor, Michael, Neufing, Petra J., Coetzee, Gerhard A., Tilley, Wayne D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell receptors Cell structures and functions Cells, Cultured DNA Primers Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Humans Immunoblotting Miscellaneous Models, Molecular Molecular and cellular biology Mutation - genetics Peptides - genetics Plasmids - genetics Receptors, Androgen - genetics Receptors, Androgen - metabolism Reverse Transcriptase Polymerase Chain Reaction Transcriptional Activation - genetics Transfection Trinucleotide Repeats - genetics
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