Efficient intracellular delivery of rifampicin to alveolar macrophages using rifampicin-loaded PLGA microspheres: effects of molecular weight and composition of PLGA on release of rifampicin

Monodispersed PLGA microspheres containing rifampicin (RFP) have been prepared by solvent evaporation method using a Shirasu porous glass (SPG) membrane. The microspheres were spherical and their average diameter was about 2 μm. The loading efficiency of rifampicin was dependent on the molecular wei...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2004-07, Vol.36 (1), p.35-42
Hauptverfasser:	Makino, Kimiko, Nakajima, Takehisa, Shikamura, Mitsuhiko, Ito, Fuminori, Ando, Shizutoshi, Kochi, Chie, Inagawa, Hiroyuki, Soma, Gen-Ichiro, Terada, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar macrophage Animals Antibiotics, Antitubercular - administration & dosage Antibiotics, Antitubercular - pharmacokinetics Cell Line Culture Media Delayed-Action Preparations Drug Delivery Systems - methods Kinetics Lactic Acid Macrophages, Alveolar - metabolism Macrophages, Alveolar - ultrastructure Microspheres Molecular Weight Particle Size Phagocytosis PLGA Polyglycolic Acid Polymers - chemistry Rats Rifampicin Rifampin - administration & dosage Rifampin - pharmacokinetics
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