An investigation of the effect of tacrine and physostigmine on spatial working memory deficits in the olfactory bulbectomised rat
The olfactory bulbectomised (OB) rat is being increasingly used as a model of impaired learning and mnemonic functioning. In this study the model has been utilised to determine the effect of the acetylcholinesterase inhibiting compounds tacrine and physostigmine on spatial working memory deficits as...
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| Veröffentlicht in: | Behavioural brain research 2004-08, Vol.153 (2), p.481-486 |
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| creator | Hallam, K.T Horgan, J.E McGrath, C Norman, T.R |
| description | The olfactory bulbectomised (OB) rat is being increasingly used as a model of impaired learning and mnemonic functioning. In this study the model has been utilised to determine the effect of the acetylcholinesterase inhibiting compounds tacrine and physostigmine on spatial working memory deficits associated with the OB rat. One-hundred and twenty male rats were randomly allocated to OB or sham operated groups and received chronic i.p. treatment with either saline, physostigmine (0.1
mg/kg) or tacrine (0.1 and 0.3
mg/kg). Two weeks after beginning treatment animals were tested on the Morris water maze and open field test. The results indicated that the OB surgery was associated with spatial working memory disturbances that were effectively attenuated with both doses of tacrine, but not physostigmine. Increased hyperactivity and defacation was observed in OB animals in the Open-field test, however, these changes were not ameliorated by either drug treatment. The ability for tacrine but not physostigmine to attenuate OB cognitive deficits may be associated with the different half-life of these compounds. This study provides further support for the use of the OB rat as a drug discovery model for the investigation of novel therapeutic compounds that target the cholinergic system. |
| doi_str_mv | 10.1016/j.bbr.2004.01.005 |
| format | Article |
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mg/kg) or tacrine (0.1 and 0.3
mg/kg). Two weeks after beginning treatment animals were tested on the Morris water maze and open field test. The results indicated that the OB surgery was associated with spatial working memory disturbances that were effectively attenuated with both doses of tacrine, but not physostigmine. Increased hyperactivity and defacation was observed in OB animals in the Open-field test, however, these changes were not ameliorated by either drug treatment. The ability for tacrine but not physostigmine to attenuate OB cognitive deficits may be associated with the different half-life of these compounds. This study provides further support for the use of the OB rat as a drug discovery model for the investigation of novel therapeutic compounds that target the cholinergic system.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2004.01.005</identifier><identifier>PMID: 15265646</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Acetylcholine ; Alzheimer Disease - physiopathology ; Alzheimers disease ; Anatomical correlates of behavior ; Animal ; Animals ; Arousal - drug effects ; Arousal - physiology ; Basal Nucleus of Meynert - drug effects ; Basal Nucleus of Meynert - physiology ; Behavioral psychophysiology ; Biological and medical sciences ; Cholinergic Fibers - drug effects ; Cholinergic Fibers - physiology ; Cholinesterase Inhibitors - pharmacology ; Defecation - drug effects ; Defecation - physiology ; Escape Reaction - drug effects ; Escape Reaction - physiology ; Fundamental and applied biological sciences. Psychology ; Injections, Intraperitoneal ; Learning. Memory ; Maze Learning - drug effects ; Maze Learning - physiology ; Memory ; Memory, Short-Term - drug effects ; Memory, Short-Term - physiology ; Morris water maze ; Motor Activity - drug effects ; Motor Activity - physiology ; Neurotransmission and behavior ; Olfactory Bulb - drug effects ; Olfactory Bulb - physiology ; Olfactory bulbectomy ; Open-field test ; Orientation - drug effects ; Orientation - physiology ; Physostigmine ; Physostigmine - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Sprague-Dawley ; Social Environment ; Spatial working memory ; Tacrine ; Tacrine - pharmacology</subject><ispartof>Behavioural brain research, 2004-08, Vol.153 (2), p.481-486</ispartof><rights>2004 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-7f3b075b7e4714c9475549160f8f58b6e1ca861412e1c8ec0b555d3b241c46a43</citedby><cites>FETCH-LOGICAL-c410t-7f3b075b7e4714c9475549160f8f58b6e1ca861412e1c8ec0b555d3b241c46a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbr.2004.01.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15985666$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15265646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hallam, K.T</creatorcontrib><creatorcontrib>Horgan, J.E</creatorcontrib><creatorcontrib>McGrath, C</creatorcontrib><creatorcontrib>Norman, T.R</creatorcontrib><title>An investigation of the effect of tacrine and physostigmine on spatial working memory deficits in the olfactory bulbectomised rat</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>The olfactory bulbectomised (OB) rat is being increasingly used as a model of impaired learning and mnemonic functioning. In this study the model has been utilised to determine the effect of the acetylcholinesterase inhibiting compounds tacrine and physostigmine on spatial working memory deficits associated with the OB rat. One-hundred and twenty male rats were randomly allocated to OB or sham operated groups and received chronic i.p. treatment with either saline, physostigmine (0.1
mg/kg) or tacrine (0.1 and 0.3
mg/kg). Two weeks after beginning treatment animals were tested on the Morris water maze and open field test. The results indicated that the OB surgery was associated with spatial working memory disturbances that were effectively attenuated with both doses of tacrine, but not physostigmine. Increased hyperactivity and defacation was observed in OB animals in the Open-field test, however, these changes were not ameliorated by either drug treatment. The ability for tacrine but not physostigmine to attenuate OB cognitive deficits may be associated with the different half-life of these compounds. This study provides further support for the use of the OB rat as a drug discovery model for the investigation of novel therapeutic compounds that target the cholinergic system.</description><subject>Acetylcholine</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimers disease</subject><subject>Anatomical correlates of behavior</subject><subject>Animal</subject><subject>Animals</subject><subject>Arousal - drug effects</subject><subject>Arousal - physiology</subject><subject>Basal Nucleus of Meynert - drug effects</subject><subject>Basal Nucleus of Meynert - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Cholinergic Fibers - drug effects</subject><subject>Cholinergic Fibers - physiology</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Defecation - drug effects</subject><subject>Defecation - physiology</subject><subject>Escape Reaction - drug effects</subject><subject>Escape Reaction - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intraperitoneal</subject><subject>Learning. Memory</subject><subject>Maze Learning - drug effects</subject><subject>Maze Learning - physiology</subject><subject>Memory</subject><subject>Memory, Short-Term - drug effects</subject><subject>Memory, Short-Term - physiology</subject><subject>Morris water maze</subject><subject>Motor Activity - drug effects</subject><subject>Motor Activity - physiology</subject><subject>Neurotransmission and behavior</subject><subject>Olfactory Bulb - drug effects</subject><subject>Olfactory Bulb - physiology</subject><subject>Olfactory bulbectomy</subject><subject>Open-field test</subject><subject>Orientation - drug effects</subject><subject>Orientation - physiology</subject><subject>Physostigmine</subject><subject>Physostigmine - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Social Environment</subject><subject>Spatial working memory</subject><subject>Tacrine</subject><subject>Tacrine - pharmacology</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvLD-CCfIFbUk_ij0ScqoovqVIv9GzZzrj1ksSLnS3aI_8cp7sSnOBke_y8r2bmJeQNsBoYyMttbW2qG8Z4zaBmTDwjG-hUUynB--dkUxhZ8bbpzsirnLesgEzAS3IGopFCcrkhv65mGuZHzEu4N0uIM42eLg9I0Xt0y9PLuBRmpGYe6O7hkOPKTmul0HlXVGakP2P6HuZ7OuEU04EO6IMLSy7eT25x9MYt64_dj7YYxylkHGgyywV54c2Y8fXpPCd3nz5-u_5S3dx-_np9dVM5DmyplG8tU8Iq5Aq467kSZUiQzHdedFYiONNJ4NCUW4eOWSHE0NqGg-PS8PacvD_67lL8sS8D69KCw3E0M8Z91lKqRjTQ_xcEJftOsraAcARdijkn9HqXwmTSQQPTa0B6q0tAeg1IM9AloKJ5ezLf2wmHP4pTIgV4dwJMdmb0ycwu5L-4vhNSrtyHI4dlZ48Bk84u4OxwCKnsVw8x_KON355irx0</recordid><startdate>20040831</startdate><enddate>20040831</enddate><creator>Hallam, K.T</creator><creator>Horgan, J.E</creator><creator>McGrath, C</creator><creator>Norman, T.R</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20040831</creationdate><title>An investigation of the effect of tacrine and physostigmine on spatial working memory deficits in the olfactory bulbectomised rat</title><author>Hallam, K.T ; Horgan, J.E ; McGrath, C ; Norman, T.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-7f3b075b7e4714c9475549160f8f58b6e1ca861412e1c8ec0b555d3b241c46a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acetylcholine</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Alzheimers disease</topic><topic>Anatomical correlates of behavior</topic><topic>Animal</topic><topic>Animals</topic><topic>Arousal - drug effects</topic><topic>Arousal - physiology</topic><topic>Basal Nucleus of Meynert - drug effects</topic><topic>Basal Nucleus of Meynert - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Cholinergic Fibers - drug effects</topic><topic>Cholinergic Fibers - physiology</topic><topic>Cholinesterase Inhibitors - pharmacology</topic><topic>Defecation - drug effects</topic><topic>Defecation - physiology</topic><topic>Escape Reaction - drug effects</topic><topic>Escape Reaction - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Intraperitoneal</topic><topic>Learning. Memory</topic><topic>Maze Learning - drug effects</topic><topic>Maze Learning - physiology</topic><topic>Memory</topic><topic>Memory, Short-Term - drug effects</topic><topic>Memory, Short-Term - physiology</topic><topic>Morris water maze</topic><topic>Motor Activity - drug effects</topic><topic>Motor Activity - physiology</topic><topic>Neurotransmission and behavior</topic><topic>Olfactory Bulb - drug effects</topic><topic>Olfactory Bulb - physiology</topic><topic>Olfactory bulbectomy</topic><topic>Open-field test</topic><topic>Orientation - drug effects</topic><topic>Orientation - physiology</topic><topic>Physostigmine</topic><topic>Physostigmine - pharmacology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Social Environment</topic><topic>Spatial working memory</topic><topic>Tacrine</topic><topic>Tacrine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hallam, K.T</creatorcontrib><creatorcontrib>Horgan, J.E</creatorcontrib><creatorcontrib>McGrath, C</creatorcontrib><creatorcontrib>Norman, T.R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hallam, K.T</au><au>Horgan, J.E</au><au>McGrath, C</au><au>Norman, T.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An investigation of the effect of tacrine and physostigmine on spatial working memory deficits in the olfactory bulbectomised rat</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2004-08-31</date><risdate>2004</risdate><volume>153</volume><issue>2</issue><spage>481</spage><epage>486</epage><pages>481-486</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>The olfactory bulbectomised (OB) rat is being increasingly used as a model of impaired learning and mnemonic functioning. In this study the model has been utilised to determine the effect of the acetylcholinesterase inhibiting compounds tacrine and physostigmine on spatial working memory deficits associated with the OB rat. One-hundred and twenty male rats were randomly allocated to OB or sham operated groups and received chronic i.p. treatment with either saline, physostigmine (0.1
mg/kg) or tacrine (0.1 and 0.3
mg/kg). Two weeks after beginning treatment animals were tested on the Morris water maze and open field test. The results indicated that the OB surgery was associated with spatial working memory disturbances that were effectively attenuated with both doses of tacrine, but not physostigmine. Increased hyperactivity and defacation was observed in OB animals in the Open-field test, however, these changes were not ameliorated by either drug treatment. The ability for tacrine but not physostigmine to attenuate OB cognitive deficits may be associated with the different half-life of these compounds. This study provides further support for the use of the OB rat as a drug discovery model for the investigation of novel therapeutic compounds that target the cholinergic system.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>15265646</pmid><doi>10.1016/j.bbr.2004.01.005</doi><tpages>6</tpages></addata></record> |
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| ispartof | Behavioural brain research, 2004-08, Vol.153 (2), p.481-486 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acetylcholine Alzheimer Disease - physiopathology Alzheimers disease Anatomical correlates of behavior Animal Animals Arousal - drug effects Arousal - physiology Basal Nucleus of Meynert - drug effects Basal Nucleus of Meynert - physiology Behavioral psychophysiology Biological and medical sciences Cholinergic Fibers - drug effects Cholinergic Fibers - physiology Cholinesterase Inhibitors - pharmacology Defecation - drug effects Defecation - physiology Escape Reaction - drug effects Escape Reaction - physiology Fundamental and applied biological sciences. Psychology Injections, Intraperitoneal Learning. Memory Maze Learning - drug effects Maze Learning - physiology Memory Memory, Short-Term - drug effects Memory, Short-Term - physiology Morris water maze Motor Activity - drug effects Motor Activity - physiology Neurotransmission and behavior Olfactory Bulb - drug effects Olfactory Bulb - physiology Olfactory bulbectomy Open-field test Orientation - drug effects Orientation - physiology Physostigmine Physostigmine - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Social Environment Spatial working memory Tacrine Tacrine - pharmacology |
| title | An investigation of the effect of tacrine and physostigmine on spatial working memory deficits in the olfactory bulbectomised rat |
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