Identification of genetic mutations associated with attenuation and changes in tropism of Urabe mumps virus

Although several effective mumps virus vaccines have been developed, almost nothing is known about the genetic changes responsible for loss of virulence. One vaccine, Urabe AM9, was withdrawn from the market because of insufficient attenuation. The vaccine was found to contain a mixture of viruses t...

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Veröffentlicht in:Journal of medical virology 2009, Vol.81 (1), p.130-138
Hauptverfasser: Shah, Dion, Vidal, Silvia, Link, Malen A, Rubin, Steven A, Wright, Kathryn E
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Sprache:eng
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