Effect of Symplocos racemosa Roxb. on gonadotropin release in immature female rats and ovarian histology
In the present study we are reporting in vivo effect of aqueous extracts of Symplocos racemosa Roxb. (Fam. Symplocaceae) on serum FSH and LH levels in immature female Sprague–Dawley rats under basal conditions. Symplocos racemosa is used in Indian System of Medicine (ISM) for various female disorder...
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| Veröffentlicht in: | Journal of ethnopharmacology 2004-09, Vol.94 (1), p.197-200 |
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| creator | Bhutani, Kamlesh Kumar Jadhav, Atul N Kalia, Vandana |
| description | In the present study we are reporting in vivo effect of aqueous extracts of
Symplocos racemosa Roxb. (Fam. Symplocaceae) on serum FSH and LH levels in immature female Sprague–Dawley rats under basal conditions.
Symplocos racemosa is used in Indian System of Medicine (ISM) for various female disorders. Aqueous extract on oral administration significantly stimulated serum FSH level (
P < 0.016) along with the rise in serum LH level (
P < 0.001). Moreover, histopathological studies revealed enhanced folliculogenesis, presence of mature follicles and detached oocytes, which are result of increased FSH and LH levels. Further, an increase in the ovary weight of treated animals was found due to observed FSH surge. These results are in concordance with the traditional use of the drug for female disorders. |
| doi_str_mv | 10.1016/j.jep.2004.04.022 |
| format | Article |
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Symplocos racemosa Roxb. (Fam. Symplocaceae) on serum FSH and LH levels in immature female Sprague–Dawley rats under basal conditions.
Symplocos racemosa is used in Indian System of Medicine (ISM) for various female disorders. Aqueous extract on oral administration significantly stimulated serum FSH level (
P < 0.016) along with the rise in serum LH level (
P < 0.001). Moreover, histopathological studies revealed enhanced folliculogenesis, presence of mature follicles and detached oocytes, which are result of increased FSH and LH levels. Further, an increase in the ovary weight of treated animals was found due to observed FSH surge. These results are in concordance with the traditional use of the drug for female disorders.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2004.04.022</identifier><identifier>PMID: 15261983</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Dose-Response Relationship, Drug ; Ericaceae ; Female ; Female disorders ; females ; Follicle Stimulating Hormone - biosynthesis ; follicle-stimulating hormone ; FSH ; General pharmacology ; Indian System of Medicine ; luteinizing hormone ; Luteinizing Hormone - biosynthesis ; Medical sciences ; medicinal plants ; Medicine, Ayurvedic ; ovaries ; Ovary - cytology ; Ovary - drug effects ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plant extracts ; Plant Extracts - pharmacology ; Rats ; Rats, Sprague-Dawley ; Symplocos ; Symplocos racemosa ; traditional medicine</subject><ispartof>Journal of ethnopharmacology, 2004-09, Vol.94 (1), p.197-200</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-da40b37080a39250e0b61cdce4c8fd4d2f9694cc6f3608e86595ee23756a24133</citedby><cites>FETCH-LOGICAL-c403t-da40b37080a39250e0b61cdce4c8fd4d2f9694cc6f3608e86595ee23756a24133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2004.04.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15980497$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15261983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhutani, Kamlesh Kumar</creatorcontrib><creatorcontrib>Jadhav, Atul N</creatorcontrib><creatorcontrib>Kalia, Vandana</creatorcontrib><title>Effect of Symplocos racemosa Roxb. on gonadotropin release in immature female rats and ovarian histology</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>In the present study we are reporting in vivo effect of aqueous extracts of
Symplocos racemosa Roxb. (Fam. Symplocaceae) on serum FSH and LH levels in immature female Sprague–Dawley rats under basal conditions.
Symplocos racemosa is used in Indian System of Medicine (ISM) for various female disorders. Aqueous extract on oral administration significantly stimulated serum FSH level (
P < 0.016) along with the rise in serum LH level (
P < 0.001). Moreover, histopathological studies revealed enhanced folliculogenesis, presence of mature follicles and detached oocytes, which are result of increased FSH and LH levels. Further, an increase in the ovary weight of treated animals was found due to observed FSH surge. These results are in concordance with the traditional use of the drug for female disorders.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ericaceae</subject><subject>Female</subject><subject>Female disorders</subject><subject>females</subject><subject>Follicle Stimulating Hormone - biosynthesis</subject><subject>follicle-stimulating hormone</subject><subject>FSH</subject><subject>General pharmacology</subject><subject>Indian System of Medicine</subject><subject>luteinizing hormone</subject><subject>Luteinizing Hormone - biosynthesis</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>Medicine, Ayurvedic</subject><subject>ovaries</subject><subject>Ovary - cytology</subject><subject>Ovary - drug effects</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Symplocos</subject><subject>Symplocos racemosa</subject><subject>traditional medicine</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U9rFDEYBvAgit1WP4AXzUVvM775M0kGT1JqFQqCteeQzbzZZpmZrMlscb-9WXZBT8ILyeH3vIQnhLxh0DJg6uO23eKu5QCyPQ7nz8iKGc0b3WnxnKxAaNMYLdkFuSxlCwCaSXhJLljHFeuNWJHHmxDQLzQFen-YdmPyqdDsPE6pOPoj_V63NM10k2Y3pCWnXZxpxhFdQVqvcZrcss9IA05uxJpcCnXzQNOTy9HN9DGWJY1pc3hFXgQ3Fnx9Pq_Iw5ebn9dfm7vvt9-uP981XoJYmsFJWAsNBpzoeQcIa8X84FF6EwY58NCrXnqvglBg0Kiu7xC50J1yXDIhrsiH095dTr_2WBY7xeJxHN2MaV-sUpoLyU2F7AR9TqVkDHaX4-TywTKwx3rt1tZ67bFeexzOa-btefl-PeHwN3Hus4L3Z-CKd2PIbvax_ON6A7LX1b07ueCSdZtczcM9ByYA-g4UU1V8OgmsZT1FzLb4iLPHIeb6YXZI8T8P_QOmyqF2</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Bhutani, Kamlesh Kumar</creator><creator>Jadhav, Atul N</creator><creator>Kalia, Vandana</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Effect of Symplocos racemosa Roxb. on gonadotropin release in immature female rats and ovarian histology</title><author>Bhutani, Kamlesh Kumar ; Jadhav, Atul N ; Kalia, Vandana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-da40b37080a39250e0b61cdce4c8fd4d2f9694cc6f3608e86595ee23756a24133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ericaceae</topic><topic>Female</topic><topic>Female disorders</topic><topic>females</topic><topic>Follicle Stimulating Hormone - biosynthesis</topic><topic>follicle-stimulating hormone</topic><topic>FSH</topic><topic>General pharmacology</topic><topic>Indian System of Medicine</topic><topic>luteinizing hormone</topic><topic>Luteinizing Hormone - biosynthesis</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>Medicine, Ayurvedic</topic><topic>ovaries</topic><topic>Ovary - cytology</topic><topic>Ovary - drug effects</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plant extracts</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Symplocos</topic><topic>Symplocos racemosa</topic><topic>traditional medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bhutani, Kamlesh Kumar</creatorcontrib><creatorcontrib>Jadhav, Atul N</creatorcontrib><creatorcontrib>Kalia, Vandana</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhutani, Kamlesh Kumar</au><au>Jadhav, Atul N</au><au>Kalia, Vandana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Symplocos racemosa Roxb. on gonadotropin release in immature female rats and ovarian histology</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>94</volume><issue>1</issue><spage>197</spage><epage>200</epage><pages>197-200</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>In the present study we are reporting in vivo effect of aqueous extracts of
Symplocos racemosa Roxb. (Fam. Symplocaceae) on serum FSH and LH levels in immature female Sprague–Dawley rats under basal conditions.
Symplocos racemosa is used in Indian System of Medicine (ISM) for various female disorders. Aqueous extract on oral administration significantly stimulated serum FSH level (
P < 0.016) along with the rise in serum LH level (
P < 0.001). Moreover, histopathological studies revealed enhanced folliculogenesis, presence of mature follicles and detached oocytes, which are result of increased FSH and LH levels. Further, an increase in the ovary weight of treated animals was found due to observed FSH surge. These results are in concordance with the traditional use of the drug for female disorders.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15261983</pmid><doi>10.1016/j.jep.2004.04.022</doi><tpages>4</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Biological and medical sciences Dose-Response Relationship, Drug Ericaceae Female Female disorders females Follicle Stimulating Hormone - biosynthesis follicle-stimulating hormone FSH General pharmacology Indian System of Medicine luteinizing hormone Luteinizing Hormone - biosynthesis Medical sciences medicinal plants Medicine, Ayurvedic ovaries Ovary - cytology Ovary - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - pharmacology Rats Rats, Sprague-Dawley Symplocos Symplocos racemosa traditional medicine |
| title | Effect of Symplocos racemosa Roxb. on gonadotropin release in immature female rats and ovarian histology |
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