Eye-head coordination in moderately affected Huntington's Disease patients: do head movements facilitate gaze shifts?
In addition to many other symptoms, Huntington's Disease (HD) also causes an impairment of oculomotor functions. In particular, saccadic eye movements become progressively slower and more difficult to initiate; ultimately, patients are forced to recur to large head thrusts as means to initiate...
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| Veröffentlicht in: | Experimental brain research 2009, Vol.192 (1), p.97-112 |
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| description | In addition to many other symptoms, Huntington's Disease (HD) also causes an impairment of oculomotor functions. In particular, saccadic eye movements become progressively slower and more difficult to initiate; ultimately, patients are forced to recur to large head thrusts as means to initiate gaze shifts. We wondered whether, as a precursor of this condition, head movements would facilitate gaze shifts already in early stages of the disease. We studied horizontal head movements and eye-head coordination in 29 early stage HD patients (Ps) and 24 age matched controls (Cs). Subjects tracked random horizontal steps of visual or auditory targets while their heads were either stabilised (saccade amplitudes |
| doi_str_mv | 10.1007/s00221-008-1559-6 |
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In particular, saccadic eye movements become progressively slower and more difficult to initiate; ultimately, patients are forced to recur to large head thrusts as means to initiate gaze shifts. We wondered whether, as a precursor of this condition, head movements would facilitate gaze shifts already in early stages of the disease. We studied horizontal head movements and eye-head coordination in 29 early stage HD patients (Ps) and 24 age matched controls (Cs). Subjects tracked random horizontal steps of visual or auditory targets while their heads were either stabilised (saccade amplitudes <=40°) or free to move (amplitudes <=160°). Subjects were to react either immediately (reactive mode), or wait until a go signal was sounded (delayed mode), or by antisaccades. Ps' head velocity was found to depend on the age of disease onset in a similar way as their saccadic eye velocity does, being clearly reduced in early affected Ps, but increasing to normal levels in lately affected Ps. Yet, saccade and head velocity were only loosely correlated although both exhibited a negative correlation with the severity of Ps' genetic condition (number of Ps' CAG repeats). Eye-head coordination turned out to be identical in Ps and Cs except for quantitative differences caused by the lower saccade and head velocities of Ps. Specifically, the timing between head and eyes and the head contribution to gaze shifts were similar in both groups. Moreover, preventing head movements did not affect the saccade latency or accuracy of Ps. Although Ps made more small involuntary head movements in this condition than Cs, these movements were not instrumental in generating saccades since they occurred only late after saccade onset. Thus, the head manoeuvres of severely affected patients must be considered a late adaptive behaviour. Finally, the ability of both Ps and Cs to suppress immediate reactions in the delayed and antisaccade conditions diminished as target distance decreased, with failure rates in Ps being much larger than in Cs. Unlike eye and head velocity, these failure rates were not correlated with age and, by the same token, neither with the variations in head and eye velocity nor with the number of CAG repeats. Hence, the pattern of brain areas prominently affected by HD is likely to vary significantly among individuals.</description><identifier>ISSN: 0014-4819</identifier><identifier>EISSN: 1432-1106</identifier><identifier>DOI: 10.1007/s00221-008-1559-6</identifier><identifier>PMID: 18807023</identifier><identifier>CODEN: EXBRAP</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Adaptation, Physiological - physiology ; Adult ; Age Factors ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Brain - physiopathology ; Brain research ; Eye and associated structures. Visual pathways and centers. Vision ; Eye movements ; Eye Movements - physiology ; Female ; Fixation, Ocular - physiology ; Fundamental and applied biological sciences. Psychology ; Head Movements - physiology ; Humans ; Huntington Disease - complications ; Huntingtons disease ; Light emitting diodes ; Male ; Middle Aged ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration ; Neck Muscles - innervation ; Neck Muscles - physiology ; Neurology ; Neuropsychological Tests ; Neurosciences ; Ocular Motility Disorders - etiology ; Ocular Motility Disorders - physiopathology ; Oculomotor Muscles - innervation ; Oculomotor Muscles - physiology ; Photic Stimulation ; Psychomotor Performance - physiology ; Reaction Time - physiology ; Research Article ; Saccades - physiology ; Time Factors ; Velocity ; Vertebrates: nervous system and sense organs</subject><ispartof>Experimental brain research, 2009, Vol.192 (1), p.97-112</ispartof><rights>Springer-Verlag 2008</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-a8a398e2b5cb85e08a2a4c799e0825ee548bda938ec44cf40e511802d25ce613</citedby><cites>FETCH-LOGICAL-c454t-a8a398e2b5cb85e08a2a4c799e0825ee548bda938ec44cf40e511802d25ce613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00221-008-1559-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00221-008-1559-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21017602$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18807023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Becker, W</creatorcontrib><creatorcontrib>Jürgens, R</creatorcontrib><creatorcontrib>Kassubek, J</creatorcontrib><creatorcontrib>Ecker, D</creatorcontrib><creatorcontrib>Kramer, B</creatorcontrib><creatorcontrib>Landwehrmeyer, B</creatorcontrib><title>Eye-head coordination in moderately affected Huntington's Disease patients: do head movements facilitate gaze shifts?</title><title>Experimental brain research</title><addtitle>Exp Brain Res</addtitle><addtitle>Exp Brain Res</addtitle><description>In addition to many other symptoms, Huntington's Disease (HD) also causes an impairment of oculomotor functions. In particular, saccadic eye movements become progressively slower and more difficult to initiate; ultimately, patients are forced to recur to large head thrusts as means to initiate gaze shifts. We wondered whether, as a precursor of this condition, head movements would facilitate gaze shifts already in early stages of the disease. We studied horizontal head movements and eye-head coordination in 29 early stage HD patients (Ps) and 24 age matched controls (Cs). Subjects tracked random horizontal steps of visual or auditory targets while their heads were either stabilised (saccade amplitudes <=40°) or free to move (amplitudes <=160°). Subjects were to react either immediately (reactive mode), or wait until a go signal was sounded (delayed mode), or by antisaccades. Ps' head velocity was found to depend on the age of disease onset in a similar way as their saccadic eye velocity does, being clearly reduced in early affected Ps, but increasing to normal levels in lately affected Ps. Yet, saccade and head velocity were only loosely correlated although both exhibited a negative correlation with the severity of Ps' genetic condition (number of Ps' CAG repeats). Eye-head coordination turned out to be identical in Ps and Cs except for quantitative differences caused by the lower saccade and head velocities of Ps. Specifically, the timing between head and eyes and the head contribution to gaze shifts were similar in both groups. Moreover, preventing head movements did not affect the saccade latency or accuracy of Ps. Although Ps made more small involuntary head movements in this condition than Cs, these movements were not instrumental in generating saccades since they occurred only late after saccade onset. Thus, the head manoeuvres of severely affected patients must be considered a late adaptive behaviour. Finally, the ability of both Ps and Cs to suppress immediate reactions in the delayed and antisaccade conditions diminished as target distance decreased, with failure rates in Ps being much larger than in Cs. Unlike eye and head velocity, these failure rates were not correlated with age and, by the same token, neither with the variations in head and eye velocity nor with the number of CAG repeats. Hence, the pattern of brain areas prominently affected by HD is likely to vary significantly among individuals.</description><subject>Adaptation, Physiological - physiology</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain - physiopathology</subject><subject>Brain research</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Eye movements</subject><subject>Eye Movements - physiology</subject><subject>Female</subject><subject>Fixation, Ocular - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Head Movements - physiology</subject><subject>Humans</subject><subject>Huntington Disease - complications</subject><subject>Huntingtons disease</subject><subject>Light emitting diodes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Neck Muscles - innervation</subject><subject>Neck Muscles - physiology</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Neurosciences</subject><subject>Ocular Motility Disorders - etiology</subject><subject>Ocular Motility Disorders - physiopathology</subject><subject>Oculomotor Muscles - innervation</subject><subject>Oculomotor Muscles - physiology</subject><subject>Photic Stimulation</subject><subject>Psychomotor Performance - physiology</subject><subject>Reaction Time - physiology</subject><subject>Research Article</subject><subject>Saccades - physiology</subject><subject>Time Factors</subject><subject>Velocity</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0014-4819</issn><issn>1432-1106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc1u1DAUhS0EosPAA7ABC6mwClz_JQ4bVJVCkSqxoKwtj3MzdZXYUztBGp4ehxlRiQWs_Pedz7YOIc8ZvGUAzbsMwDmrAHTFlGqr-gFZMSl4xRjUD8kKgMlKataekCc53y5L0cBjcsK0hga4WJH5Yo_VDdqOuhhT54OdfAzUBzrGDpOdcNhT2_foJuzo5RwmH7ZTDG8y_egz2ox0VyIYpvyedpH-Vo3xB47LFu2t84OfioZu7U-k-cb3U_7wlDzq7ZDx2XFck-tPF9fnl9XV189fzs-uKieVnCqrrWg18o1yG60QtOVWuqZty5QrRCX1prOt0OikdL0EVIxp4B1XDmsm1uT1QbtL8W7GPJnRZ4fDYAPGOZu6brhgNfwXZK0C0eimgK_-Am_jnEL5g-FMMSFatUDsALkUc07Ym13yo017w8AsxZlDcaYUZ5biTF0yL47ieTNid584NlWA0yNgs7NDn2xwPv_hOAPW1AVcE37gcjkKW0z3L_zX7S8Pod5GY7epiL9_48AELIDkSvwCEBa5ig</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Becker, W</creator><creator>Jürgens, R</creator><creator>Kassubek, J</creator><creator>Ecker, D</creator><creator>Kramer, B</creator><creator>Landwehrmeyer, B</creator><general>Berlin/Heidelberg : Springer-Verlag</general><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2R</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>2009</creationdate><title>Eye-head coordination in moderately affected Huntington's Disease patients: do head movements facilitate gaze shifts?</title><author>Becker, W ; Jürgens, R ; Kassubek, J ; Ecker, D ; Kramer, B ; Landwehrmeyer, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-a8a398e2b5cb85e08a2a4c799e0825ee548bda938ec44cf40e511802d25ce613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adaptation, Physiological - physiology</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain - physiopathology</topic><topic>Brain research</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Eye movements</topic><topic>Eye Movements - physiology</topic><topic>Female</topic><topic>Fixation, Ocular - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Head Movements - physiology</topic><topic>Humans</topic><topic>Huntington Disease - complications</topic><topic>Huntingtons disease</topic><topic>Light emitting diodes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Neck Muscles - innervation</topic><topic>Neck Muscles - physiology</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Neurosciences</topic><topic>Ocular Motility Disorders - etiology</topic><topic>Ocular Motility Disorders - physiopathology</topic><topic>Oculomotor Muscles - innervation</topic><topic>Oculomotor Muscles - physiology</topic><topic>Photic Stimulation</topic><topic>Psychomotor Performance - physiology</topic><topic>Reaction Time - physiology</topic><topic>Research Article</topic><topic>Saccades - physiology</topic><topic>Time Factors</topic><topic>Velocity</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Becker, W</creatorcontrib><creatorcontrib>Jürgens, R</creatorcontrib><creatorcontrib>Kassubek, J</creatorcontrib><creatorcontrib>Ecker, D</creatorcontrib><creatorcontrib>Kramer, B</creatorcontrib><creatorcontrib>Landwehrmeyer, B</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Social Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Becker, W</au><au>Jürgens, R</au><au>Kassubek, J</au><au>Ecker, D</au><au>Kramer, B</au><au>Landwehrmeyer, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eye-head coordination in moderately affected Huntington's Disease patients: do head movements facilitate gaze shifts?</atitle><jtitle>Experimental brain research</jtitle><stitle>Exp Brain Res</stitle><addtitle>Exp Brain Res</addtitle><date>2009</date><risdate>2009</risdate><volume>192</volume><issue>1</issue><spage>97</spage><epage>112</epage><pages>97-112</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><coden>EXBRAP</coden><abstract>In addition to many other symptoms, Huntington's Disease (HD) also causes an impairment of oculomotor functions. In particular, saccadic eye movements become progressively slower and more difficult to initiate; ultimately, patients are forced to recur to large head thrusts as means to initiate gaze shifts. We wondered whether, as a precursor of this condition, head movements would facilitate gaze shifts already in early stages of the disease. We studied horizontal head movements and eye-head coordination in 29 early stage HD patients (Ps) and 24 age matched controls (Cs). Subjects tracked random horizontal steps of visual or auditory targets while their heads were either stabilised (saccade amplitudes <=40°) or free to move (amplitudes <=160°). Subjects were to react either immediately (reactive mode), or wait until a go signal was sounded (delayed mode), or by antisaccades. Ps' head velocity was found to depend on the age of disease onset in a similar way as their saccadic eye velocity does, being clearly reduced in early affected Ps, but increasing to normal levels in lately affected Ps. Yet, saccade and head velocity were only loosely correlated although both exhibited a negative correlation with the severity of Ps' genetic condition (number of Ps' CAG repeats). Eye-head coordination turned out to be identical in Ps and Cs except for quantitative differences caused by the lower saccade and head velocities of Ps. Specifically, the timing between head and eyes and the head contribution to gaze shifts were similar in both groups. Moreover, preventing head movements did not affect the saccade latency or accuracy of Ps. Although Ps made more small involuntary head movements in this condition than Cs, these movements were not instrumental in generating saccades since they occurred only late after saccade onset. Thus, the head manoeuvres of severely affected patients must be considered a late adaptive behaviour. Finally, the ability of both Ps and Cs to suppress immediate reactions in the delayed and antisaccade conditions diminished as target distance decreased, with failure rates in Ps being much larger than in Cs. Unlike eye and head velocity, these failure rates were not correlated with age and, by the same token, neither with the variations in head and eye velocity nor with the number of CAG repeats. Hence, the pattern of brain areas prominently affected by HD is likely to vary significantly among individuals.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>18807023</pmid><doi>10.1007/s00221-008-1559-6</doi><tpages>16</tpages></addata></record> |
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| subjects | Adaptation, Physiological - physiology Adult Age Factors Biological and medical sciences Biomedical and Life Sciences Biomedicine Brain - physiopathology Brain research Eye and associated structures. Visual pathways and centers. Vision Eye movements Eye Movements - physiology Female Fixation, Ocular - physiology Fundamental and applied biological sciences. Psychology Head Movements - physiology Humans Huntington Disease - complications Huntingtons disease Light emitting diodes Male Middle Aged Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Neck Muscles - innervation Neck Muscles - physiology Neurology Neuropsychological Tests Neurosciences Ocular Motility Disorders - etiology Ocular Motility Disorders - physiopathology Oculomotor Muscles - innervation Oculomotor Muscles - physiology Photic Stimulation Psychomotor Performance - physiology Reaction Time - physiology Research Article Saccades - physiology Time Factors Velocity Vertebrates: nervous system and sense organs |
| title | Eye-head coordination in moderately affected Huntington's Disease patients: do head movements facilitate gaze shifts? |
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