Fibrinogen and high molecular weight fibrinogen during and after normal pregnancy
Introduction: Pregnancy has recently been described as a generalized intravascular inflammatory response to the conceptus. Total fibrinogen concentrations increase during pregnancy. The percentage high molecular weight fibrinogen (HMW-Fg) of the concentration total fibrinogen is known to increase du...
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| Veröffentlicht in: | Thrombosis research 2004, Vol.114 (1), p.19-23 |
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| creator | Manten, Gwendolyn T.R Franx, Arie Sikkema, J.M Hameeteman, Ton M Visser, Gerard H.A de Groot, Philip G Voorbij, Hieronymus A.M |
| description | Introduction: Pregnancy has recently been described as a generalized intravascular inflammatory response to the conceptus. Total fibrinogen concentrations increase during pregnancy. The percentage high molecular weight fibrinogen (HMW-Fg) of the concentration total fibrinogen is known to increase during acute-phase conditions like inflammation. Therefore, we investigated whether the percentage high molecular weight fibrinogen increases during normal pregnancy.
Materials and Methods: Eighteen healthy nulliparous women with uncomplicated pregnancies with normal course and outcome participated in this study. Five blood samples were drawn from every woman in the gestational age periods 9 to 16, 17 to 24, 25 to 33 and 34 to 42 weeks and at 12 to 20 weeks after delivery. Total fibrinogen concentrations were determined according to Clauss and the percentage high molecular weight fibrinogen was assessed by SDS-electrophoresis and densitometry after isolation of fibrinogen by precipitation. One-way analysis of variance (ANOVA) was used to evaluate differences between gestational age periods and correlation coefficients were calculated by Pearson's method.
Results: Total fibrinogen concentrations increased with advancing gestational age and decreased after delivery. The percentage high molecular weight fibrinogen of the total fibrinogen remained unaltered during and after pregnancy.
Conclusions: During normal pregnancy, there is an increase of total fibrinogen concentrations with advancing gestational age, without a rise in percentage high molecular weight fibrinogen. After delivery, the total fibrinogen returns to baseline concentrations. |
| doi_str_mv | 10.1016/j.thromres.2004.04.008 |
| format | Article |
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Materials and Methods: Eighteen healthy nulliparous women with uncomplicated pregnancies with normal course and outcome participated in this study. Five blood samples were drawn from every woman in the gestational age periods 9 to 16, 17 to 24, 25 to 33 and 34 to 42 weeks and at 12 to 20 weeks after delivery. Total fibrinogen concentrations were determined according to Clauss and the percentage high molecular weight fibrinogen was assessed by SDS-electrophoresis and densitometry after isolation of fibrinogen by precipitation. One-way analysis of variance (ANOVA) was used to evaluate differences between gestational age periods and correlation coefficients were calculated by Pearson's method.
Results: Total fibrinogen concentrations increased with advancing gestational age and decreased after delivery. The percentage high molecular weight fibrinogen of the total fibrinogen remained unaltered during and after pregnancy.
Conclusions: During normal pregnancy, there is an increase of total fibrinogen concentrations with advancing gestational age, without a rise in percentage high molecular weight fibrinogen. After delivery, the total fibrinogen returns to baseline concentrations.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/j.thromres.2004.04.008</identifier><identifier>PMID: 15262480</identifier><identifier>CODEN: THBRAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Ltd</publisher><subject>Adult ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood coagulation. Blood cells ; Blood. Blood coagulation. Reticuloendothelial system ; Cardiology. Vascular system ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Female ; Fibrinogen ; Fibrinogen - analysis ; Fibrinogen - chemistry ; Fibrinogen - classification ; Fundamental and applied biological sciences. Psychology ; Gestational Age ; Hemostasis - physiology ; High molecular weight fibrinogen ; Humans ; Medical sciences ; Molecular and cellular biology ; Molecular Weight ; Normal pregnancy ; Pharmacology. Drug treatments ; Platelet ; Postpartum Period - blood ; Pregnancy - blood ; Statistics as Topic</subject><ispartof>Thrombosis research, 2004, Vol.114 (1), p.19-23</ispartof><rights>2004 Elsevier Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-fa5d4d6cd1fbcec3bb5bd1c108eecd5911001cf7280d6bd8ba388ddcc0646ce83</citedby><cites>FETCH-LOGICAL-c460t-fa5d4d6cd1fbcec3bb5bd1c108eecd5911001cf7280d6bd8ba388ddcc0646ce83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0049384804002282$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15972809$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15262480$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manten, Gwendolyn T.R</creatorcontrib><creatorcontrib>Franx, Arie</creatorcontrib><creatorcontrib>Sikkema, J.M</creatorcontrib><creatorcontrib>Hameeteman, Ton M</creatorcontrib><creatorcontrib>Visser, Gerard H.A</creatorcontrib><creatorcontrib>de Groot, Philip G</creatorcontrib><creatorcontrib>Voorbij, Hieronymus A.M</creatorcontrib><title>Fibrinogen and high molecular weight fibrinogen during and after normal pregnancy</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>Introduction: Pregnancy has recently been described as a generalized intravascular inflammatory response to the conceptus. Total fibrinogen concentrations increase during pregnancy. The percentage high molecular weight fibrinogen (HMW-Fg) of the concentration total fibrinogen is known to increase during acute-phase conditions like inflammation. Therefore, we investigated whether the percentage high molecular weight fibrinogen increases during normal pregnancy.
Materials and Methods: Eighteen healthy nulliparous women with uncomplicated pregnancies with normal course and outcome participated in this study. Five blood samples were drawn from every woman in the gestational age periods 9 to 16, 17 to 24, 25 to 33 and 34 to 42 weeks and at 12 to 20 weeks after delivery. Total fibrinogen concentrations were determined according to Clauss and the percentage high molecular weight fibrinogen was assessed by SDS-electrophoresis and densitometry after isolation of fibrinogen by precipitation. One-way analysis of variance (ANOVA) was used to evaluate differences between gestational age periods and correlation coefficients were calculated by Pearson's method.
Results: Total fibrinogen concentrations increased with advancing gestational age and decreased after delivery. The percentage high molecular weight fibrinogen of the total fibrinogen remained unaltered during and after pregnancy.
Conclusions: During normal pregnancy, there is an increase of total fibrinogen concentrations with advancing gestational age, without a rise in percentage high molecular weight fibrinogen. After delivery, the total fibrinogen returns to baseline concentrations.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood coagulation. Blood cells</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Cardiology. Vascular system</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Female</subject><subject>Fibrinogen</subject><subject>Fibrinogen - analysis</subject><subject>Fibrinogen - chemistry</subject><subject>Fibrinogen - classification</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gestational Age</subject><subject>Hemostasis - physiology</subject><subject>High molecular weight fibrinogen</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Molecular and cellular biology</subject><subject>Molecular Weight</subject><subject>Normal pregnancy</subject><subject>Pharmacology. Drug treatments</subject><subject>Platelet</subject><subject>Postpartum Period - blood</subject><subject>Pregnancy - blood</subject><subject>Statistics as Topic</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LwzAUhoMobk7_wuiN3rUmXZumd8pwKgxE0OuQnpxuGf2YSavs35u6ybwTDiQhz0ne8xAyZTRilPHbTdStbVtbdFFMaRINRcUJGTOR5WGcZPEpGfuLPJyJRIzIhXMbSlnG8vScjFga8zgRdExeF6awpmlX2ASq0cHarNZB3VYIfaVs8IX-3AXlEdK9361-WFV2aIOmtbWqgq3FVaMa2F2Ss1JVDq8O64S8Lx7e5k_h8uXxeX6_DCHhtAtLlepEc9CsLABhVhRpoRkwKhBBpzljPi6UWSyo5oUWhZoJoTUA5QkHFLMJudm_u7XtR4-uk7VxgFWlGmx7Jzn3w2ZiAPkeBNs6Z7GUW2tqZXeSUTnIlBv5K1MOMuVQdGicHn7oixr1se1gzwPXB0A5UFVp_fzG_eHyIX7uubs9h97Hp0ErHRhsALWxCJ3UrfkvyzewvJjC</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>Manten, Gwendolyn T.R</creator><creator>Franx, Arie</creator><creator>Sikkema, J.M</creator><creator>Hameeteman, Ton M</creator><creator>Visser, Gerard H.A</creator><creator>de Groot, Philip G</creator><creator>Voorbij, Hieronymus A.M</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2004</creationdate><title>Fibrinogen and high molecular weight fibrinogen during and after normal pregnancy</title><author>Manten, Gwendolyn T.R ; Franx, Arie ; Sikkema, J.M ; Hameeteman, Ton M ; Visser, Gerard H.A ; de Groot, Philip G ; Voorbij, Hieronymus A.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-fa5d4d6cd1fbcec3bb5bd1c108eecd5911001cf7280d6bd8ba388ddcc0646ce83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood coagulation. Blood cells</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Cardiology. Vascular system</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Female</topic><topic>Fibrinogen</topic><topic>Fibrinogen - analysis</topic><topic>Fibrinogen - chemistry</topic><topic>Fibrinogen - classification</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gestational Age</topic><topic>Hemostasis - physiology</topic><topic>High molecular weight fibrinogen</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Molecular and cellular biology</topic><topic>Molecular Weight</topic><topic>Normal pregnancy</topic><topic>Pharmacology. Drug treatments</topic><topic>Platelet</topic><topic>Postpartum Period - blood</topic><topic>Pregnancy - blood</topic><topic>Statistics as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manten, Gwendolyn T.R</creatorcontrib><creatorcontrib>Franx, Arie</creatorcontrib><creatorcontrib>Sikkema, J.M</creatorcontrib><creatorcontrib>Hameeteman, Ton M</creatorcontrib><creatorcontrib>Visser, Gerard H.A</creatorcontrib><creatorcontrib>de Groot, Philip G</creatorcontrib><creatorcontrib>Voorbij, Hieronymus A.M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manten, Gwendolyn T.R</au><au>Franx, Arie</au><au>Sikkema, J.M</au><au>Hameeteman, Ton M</au><au>Visser, Gerard H.A</au><au>de Groot, Philip G</au><au>Voorbij, Hieronymus A.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fibrinogen and high molecular weight fibrinogen during and after normal pregnancy</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>2004</date><risdate>2004</risdate><volume>114</volume><issue>1</issue><spage>19</spage><epage>23</epage><pages>19-23</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><coden>THBRAA</coden><abstract>Introduction: Pregnancy has recently been described as a generalized intravascular inflammatory response to the conceptus. Total fibrinogen concentrations increase during pregnancy. The percentage high molecular weight fibrinogen (HMW-Fg) of the concentration total fibrinogen is known to increase during acute-phase conditions like inflammation. Therefore, we investigated whether the percentage high molecular weight fibrinogen increases during normal pregnancy.
Materials and Methods: Eighteen healthy nulliparous women with uncomplicated pregnancies with normal course and outcome participated in this study. Five blood samples were drawn from every woman in the gestational age periods 9 to 16, 17 to 24, 25 to 33 and 34 to 42 weeks and at 12 to 20 weeks after delivery. Total fibrinogen concentrations were determined according to Clauss and the percentage high molecular weight fibrinogen was assessed by SDS-electrophoresis and densitometry after isolation of fibrinogen by precipitation. One-way analysis of variance (ANOVA) was used to evaluate differences between gestational age periods and correlation coefficients were calculated by Pearson's method.
Results: Total fibrinogen concentrations increased with advancing gestational age and decreased after delivery. The percentage high molecular weight fibrinogen of the total fibrinogen remained unaltered during and after pregnancy.
Conclusions: During normal pregnancy, there is an increase of total fibrinogen concentrations with advancing gestational age, without a rise in percentage high molecular weight fibrinogen. After delivery, the total fibrinogen returns to baseline concentrations.</abstract><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>15262480</pmid><doi>10.1016/j.thromres.2004.04.008</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Blood and lymphatic vessels Blood coagulation. Blood cells Blood. Blood coagulation. Reticuloendothelial system Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Fibrinogen Fibrinogen - analysis Fibrinogen - chemistry Fibrinogen - classification Fundamental and applied biological sciences. Psychology Gestational Age Hemostasis - physiology High molecular weight fibrinogen Humans Medical sciences Molecular and cellular biology Molecular Weight Normal pregnancy Pharmacology. Drug treatments Platelet Postpartum Period - blood Pregnancy - blood Statistics as Topic |
| title | Fibrinogen and high molecular weight fibrinogen during and after normal pregnancy |
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