Acquisition of anergic and suppressive activities in transforming growth factor-β-costimulated CD4+CD25− T cells

Regulatory T (Tr) cells have been shown to arise in the periphery during induction of peripheral tolerance. However, the mechanism involved remains elusive. In the present study, we investigated the potential role of transforming growth factor (TGF)-β in the peripheral induction of regulatory phenot...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International immunology 2004-08, Vol.16 (8), p.1203-1213
Hauptverfasser:	Park, Hyung-Bae, Paik, Doo-Jin, Jang, Eunkyeong, Hong, Seokmann, Youn, Jeehee
Format:	Artikel
Sprache:	eng
Schlagworte:	anergy Animals Antigens, CD - immunology Antigens, Differentiation - immunology Antigens, Differentiation, T-Lymphocyte - immunology CD4-Positive T-Lymphocytes - immunology Cell Communication - immunology Cell Proliferation - drug effects Cells, Cultured CFSE carboxy-fluorescein diacetate succinimidyl ester CTLA-4 cytotoxic T lymphocyte-associated antigen 4 Foxp3 Foxp3 forkhead box p3 Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Humans Immune Tolerance - drug effects Immune Tolerance - immunology Interleukin-10 - immunology Interleukin-2 - immunology Lectins, C-Type LN lymph node Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Mice PD-1 PD-1 programmed death-1 Programmed Cell Death 1 Receptor Receptors, Interleukin-2 - immunology regulatory T cells TGF-β Transforming Growth Factor beta - pharmacology Tr regulatory T cell
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!