Betaine structure and the presence of hydroxyl groups alters the effects on DNA melting temperatures

Betaine lowers the melting temperature of deoxyribonucleic acid (DNA) and decreases its dependence on base composition. The effects of synthetic betaine analogs on the melting of DNA samples with different GC content were measured. Since many polyhydroxy compounds also lower DNA melting temperatures...

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Veröffentlicht in:	Biopolymers 2009-01, Vol.91 (1), p.85-94
Hauptverfasser:	Vasudevamurthy, Madhusudan K., Lever, Michael, George, Peter M., Morison, Ken R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals betaine Betaine - chemistry Biological Products - chemistry Cattle compensatory solutes DNA - chemistry DNA melting DNA stability Hydroxylation Molecular Structure Nucleic Acid Denaturation osmolytes PCR reagents Transition Temperature
Online-Zugang:	Volltext
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